Monocyte-Derived Dendritic Cell Differentiation in Inflammatory Arthritis Is Regulated by the JAK/STAT Axis via NADPH Oxidase Regulation.
Arthritis, Psoriatic
/ immunology
Arthritis, Rheumatoid
/ immunology
Cell Differentiation
/ immunology
Dendritic Cells
/ drug effects
Humans
Janus Kinases
/ metabolism
Monocytes
/ immunology
NADPH Oxidases
/ metabolism
Piperidines
/ pharmacology
Protein Kinase Inhibitors
/ pharmacology
Pyrimidines
/ pharmacology
STAT Transcription Factors
/ metabolism
Signal Transduction
/ drug effects
NADPH oxidase
differentiation
inflammatory arthritis
monocyte-derived dendritic cells
tofacitinib
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
13
03
2020
accepted:
01
06
2020
entrez:
1
8
2020
pubmed:
1
8
2020
medline:
7
4
2021
Statut:
epublish
Résumé
Monocyte-derived Dendritic cells (Mo-DC) are a distinct DC subset, involved in inflammation and infection, they originate from monocytes upon stimulation in the circulation and their activation and function may vary in autoimmune diseases. In this study we investigate the differences in Mo-DC differentiation and function in patients with Rheumatoid (RA) compared to Psoriatic arthritis (PsA). A significant increase in the Mo-DC differentiation marker CD209, paralleled by a corresponding decrease in the monocytic marker CD14, was demonstrated in RA compared to PsA, as early as 1 day post Mo-DC differentiation. RA monocytes
Identifiants
pubmed: 32733468
doi: 10.3389/fimmu.2020.01406
pmc: PMC7358435
doi:
Substances chimiques
Piperidines
0
Protein Kinase Inhibitors
0
Pyrimidines
0
STAT Transcription Factors
0
tofacitinib
87LA6FU830
NADPH Oxidases
EC 1.6.3.-
Janus Kinases
EC 2.7.10.2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1406Informations de copyright
Copyright © 2020 Marzaioli, Canavan, Floudas, Wade, Low, Veale and Fearon.
Références
Arthritis Res Ther. 2009;11(3):R100
pubmed: 19563672
Arthritis Res Ther. 2013;15(6):128
pubmed: 24365031
PLoS One. 2013 Oct 30;8(10):e79098
pubmed: 24205367
Oncol Lett. 2015 Dec;10(6):3471-3477
pubmed: 26788152
Hum Immunol. 2008 Oct;69(10):625-33
pubmed: 18703103
Immunology. 2018 May;154(1):3-20
pubmed: 29313948
Int J Clin Pharmacol Res. 2005;25(1):9-18
pubmed: 15864873
Immunity. 2007 Apr;26(4):519-31
pubmed: 17412618
Br J Pharmacol. 2011 Sep;164(2b):507-20
pubmed: 21501142
Front Immunol. 2018 May 09;9:755
pubmed: 29867920
J Rheumatol. 2012 Jun;39(6):1192-7
pubmed: 22467922
Cytometry A. 2011 Feb;79(2):167-74
pubmed: 21265010
Clin Exp Immunol. 2017 Aug;189(2):250-258
pubmed: 28369741
Front Immunol. 2019 Mar 26;10:541
pubmed: 30984167
Nat Rev Immunol. 2011 Oct 10;11(11):762-74
pubmed: 21984070
Nat Immunol. 2004 Oct;5(10):971-4
pubmed: 15454919
PLoS Pathog. 2010 Apr 22;6(4):e1000866
pubmed: 20421949
Nat Rev Immunol. 2012 Jul 13;12(8):557-69
pubmed: 22790179
JCI Insight. 2018 Dec 6;3(23):
pubmed: 30518680
Immunity. 1999 Dec;11(6):753-61
pubmed: 10626897
Eur J Immunol. 2012 Oct;42(10):2535-43
pubmed: 23042650
Arthritis Res Ther. 2008;10 Suppl 1:S2
pubmed: 19007422
Front Pharmacol. 2016 Nov 25;7:455
pubmed: 27932984
Front Biosci (Schol Ed). 2010 Jan 01;2:153-67
pubmed: 20036936
Hum Immunol. 2016 Oct;77(10):930-936
pubmed: 27421624
Blood. 2017 Oct 12;130(15):1734-1745
pubmed: 28830888
Blood. 2008 Dec 1;112(12):4712-22
pubmed: 18682599
Ann Rheum Dis. 2015 Jun;74(6):1275-83
pubmed: 24525913
PLoS One. 2013;8(1):e55487
pubmed: 23383203
RMD Open. 2015 Apr 28;1(1):e000025
pubmed: 26509055
Oncoimmunology. 2013 May 1;2(5):e23851
pubmed: 23762786
Arthritis Res Ther. 2016 Dec 1;18(1):287
pubmed: 27908288
Arthritis Res Ther. 2005;7(2):R217-29
pubmed: 15743468
Arthritis Res Ther. 2016 Apr 22;18:92
pubmed: 27102815
Ann Rheum Dis. 2018 Feb;77(2):300-308
pubmed: 29191820
Ann Rheum Dis. 2016 May;75(5):899-907
pubmed: 25923217
Mol Cell Biochem. 2017 Jun;430(1-2):161-169
pubmed: 28214951
Arthritis Res Ther. 2006;8(1):R15
pubmed: 16507115
Clin Exp Immunol. 1986 Mar;63(3):594-600
pubmed: 2940038
J Vis Exp. 2018 Oct 17;(140):
pubmed: 30394370
Int Immunol. 2000 Jul;12(7):987-94
pubmed: 10882410
Front Immunol. 2019 Mar 01;10:188
pubmed: 30881356
Rheumatol Ther. 2018 Dec;5(2):567-582
pubmed: 30414064
Annu Rev Immunol. 2005;23:975-1028
pubmed: 15771591
Arthritis Res Ther. 2013 Oct 20;15(5):R155
pubmed: 24286358
PLoS One. 2018 May 10;13(5):e0196591
pubmed: 29746488
Ann Rheum Dis. 2014 Dec;73(12):2192-8
pubmed: 24013646
J Immunol. 2011 Apr 1;186(7):4234-43
pubmed: 21383241
Eur J Immunol. 2011 Apr;41(4):963-73
pubmed: 21381021
Immunity. 2013 Feb 21;38(2):336-48
pubmed: 23352235
J Immunol. 2002 Mar 1;168(5):2118-26
pubmed: 11859097
Arthritis Rheumatol. 2018 Dec;70(12):1959-1970
pubmed: 29790294
RMD Open. 2016 Sep 28;2(2):e000308
pubmed: 27752357
J Exp Med. 1994 Apr 1;179(4):1109-18
pubmed: 8145033
Cell. 2006 Jul 14;126(1):205-18
pubmed: 16839887
Arthritis Rheum. 1985 Apr;28(4):395-404
pubmed: 3986006
J Immunol Res. 2019 Jun 11;2019:7458238
pubmed: 31309123
Ann Rheum Dis. 2016 Jan;75(1):311-5
pubmed: 26353790
Circ Res. 2001 Aug 31;89(5):408-14
pubmed: 11532901
Sci Rep. 2018 Mar 27;8(1):5273
pubmed: 29588471
J Exp Med. 2018 Nov 5;215(11):2725-2736
pubmed: 30355614
Transplantation. 2012 Sep 15;94(5):465-72
pubmed: 22960764
Arthritis Res. 2002;4 Suppl 3:S183-8
pubmed: 12110138
J Immunol. 2002 Dec 15;169(12):7071-7
pubmed: 12471143
Immunology. 2013 Sep;140(1):22-30
pubmed: 23621371