Myocardial strain indices and coronary flow reserve are only mildly affected in healthy hypertensive patients.
Adult
Aged
Arterial Pressure
Blood Flow Velocity
Case-Control Studies
Coronary Circulation
Dipyridamole
/ administration & dosage
Echocardiography, Doppler
Echocardiography, Stress
Heart Diseases
/ diagnostic imaging
Humans
Hypertension
/ complications
Infusions, Intravenous
Male
Microcirculation
Middle Aged
Myocardial Contraction
Predictive Value of Tests
Prospective Studies
Stroke Volume
Vasodilator Agents
/ administration & dosage
Ventricular Function, Left
Arterial hypertension
Coronary flow reserve
Dipyridamole stress test
Myocardial strain
Speckle tracking
Journal
The international journal of cardiovascular imaging
ISSN: 1875-8312
Titre abrégé: Int J Cardiovasc Imaging
Pays: United States
ID NLM: 100969716
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
received:
29
03
2020
accepted:
20
07
2020
pubmed:
1
8
2020
medline:
13
4
2021
entrez:
1
8
2020
Statut:
ppublish
Résumé
To investigate changes in two-dimensional myocardial strain echocardiography (2DSTE) indices following a dipyridamole stress test (DIPSE) in relatively healthy hypertensive patients and healthy controls. Forty-seven male hypertensive patients (aged 57±9 years) with normal ejection fraction and without left ventricular (LV) hypertrophy and 20 healthy male subjects were studied with conventional and 2DSTE echocardiography at rest and post DIPSE. Coronary flow reserve (CFR) in the left anterior descending artery following DIPSE was also evaluated. Global longitudinal strain (GLS) and TWIST were higher while UNTWIST rate was lower in hypertensives versus controls (p < 0.05 for all); TWIST remained higher in hypertensives (p = 0.021) after adjustment for differences in age and body mass index (BMI) between the groups. CFR was higher in controls compared to hypertensives even after adjustment for confounders (4.14 vs. 2.53, p = 0.001). DIPSE-induced changes did not differ between the groups after adjustment for age and BMI (p > 0.05 for all). DIPSE-induced improvement in GLS was associated with higher CFR only in hypertensive patients (r - 0.372, p = 0.010). The current study showed that well controlled hypertensive patients have only mild echocardiographic differences compared to controls; some of these differences appear to depend on age and BMI. A 'hyper-rotation' phenomenon (i.e. higher TWIST) early in hypertension may be a compensatory mechanism to preserve global systolic LV function. Coronary microcirculatory function was impaired in hypertensive patients, albeit within normal range, and was associated with DIPSE-induced changes in myocardial long-axis systolic function.
Identifiants
pubmed: 32734496
doi: 10.1007/s10554-020-01947-w
pii: 10.1007/s10554-020-01947-w
doi:
Substances chimiques
Vasodilator Agents
0
Dipyridamole
64ALC7F90C
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
69-79Références
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