Structure-function of platelet glycoprotein Ib-IX.
glycoprotein Ib
mechanoreceptor
platelet
thrombocytopenia
thrombosis
Journal
Journal of thrombosis and haemostasis : JTH
ISSN: 1538-7836
Titre abrégé: J Thromb Haemost
Pays: England
ID NLM: 101170508
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
19
05
2020
revised:
13
07
2020
accepted:
17
07
2020
pubmed:
1
8
2020
medline:
15
5
2021
entrez:
1
8
2020
Statut:
ppublish
Résumé
The glycoprotein (GP)Ib-IX receptor complex plays a critical role in platelet physiology and pathology. Its interaction with von Willebrand factor (VWF) on the subendothelial matrix instigates platelet arrest at the site of vascular injury and is vital to primary hemostasis. Its reception to other ligands and counter-receptors in the bloodstream also contribute to various processes of platelet biology that are still being discovered. While its basic composition and its link to congenital bleeding disorders were well documented and firmly established more than 25 years ago, recent years have witnessed critical advances in the organization, dynamics, activation, regulation, and functions of the GPIb-IX complex. This review summarizes important findings and identifies questions that remain about this unique platelet mechanoreceptor complex.
Identifiants
pubmed: 32735697
doi: 10.1111/jth.15035
pmc: PMC7854888
mid: NIHMS1628045
pii: S1538-7836(22)03757-6
doi:
Substances chimiques
Ligands
0
Platelet Glycoprotein GPIb-IX Complex
0
von Willebrand Factor
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
3131-3141Subventions
Organisme : NHLBI NIH HHS
ID : R21 HL146299
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL143794
Pays : United States
Organisme : NHLBI NIH HHS
ID : HL143794
Pays : United States
Organisme : NHLBI NIH HHS
ID : HL134241
Pays : United States
Organisme : NHLBI NIH HHS
ID : HL146299
Pays : United States
Organisme : NHLBI NIH HHS
ID : F31 HL134241
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL082808
Pays : United States
Organisme : NHLBI NIH HHS
ID : HL082808
Pays : United States
Informations de copyright
© 2020 International Society on Thrombosis and Haemostasis.
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