MDS criteria for the diagnosis of progressive supranuclear palsy overemphasize Richardson syndrome.
Accidental Falls
Aged
Aged, 80 and over
Atrophy
/ pathology
Female
Humans
Magnetic Resonance Imaging
Male
Mesencephalon
/ diagnostic imaging
Middle Aged
Pons
/ diagnostic imaging
Postural Balance
/ physiology
Practice Guidelines as Topic
/ standards
Retrospective Studies
Supranuclear Palsy, Progressive
/ diagnosis
Journal
Annals of clinical and translational neurology
ISSN: 2328-9503
Titre abrégé: Ann Clin Transl Neurol
Pays: United States
ID NLM: 101623278
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
18
02
2020
revised:
09
04
2020
accepted:
23
04
2020
pubmed:
1
8
2020
medline:
21
10
2021
entrez:
1
8
2020
Statut:
ppublish
Résumé
MDS-criteria for clinical diagnosis of progressive supranuclear palsy (PSP) were recently published, their usability in a classical clinical setting is yet unknown. We retrospectively applied the new criteria using PSP patients' case files. Assignment of PSP diagnosis according to the MDS-criteria was possible in 57/80 cases. The main difference to former specialist classification was a lower phenotype diversity and higher representation of PSP-RS. Furthermore, we examined those patients' brain MRIs. While neuroradiologists' reports were suggestive of PSP only in 11/62, the analysis of a blinded rater revealed pathological midbrain-to-pons-ratio in 40/62 implying this imaging feature is often missed.
Identifiants
pubmed: 32735745
doi: 10.1002/acn3.51065
pmc: PMC7480918
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1702-1707Informations de copyright
© 2020 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.
Références
Neurology. 1996 Jul;47(1):1-9
pubmed: 8710059
Eur J Neurol. 2013 Oct;20(10):1417-22
pubmed: 23746093
Neurology. 2013 May 14;80(20):1856-61
pubmed: 23616165
Mov Disord. 2017 Jul;32(7):955-971
pubmed: 28500751
Mov Disord. 2020 Jun;35(6):976-983
pubmed: 32092195
CNS Neurosci Ther. 2019 Feb;25(2):159-174
pubmed: 30294976
Mov Disord. 2017 Jun;32(6):853-864
pubmed: 28467028
Mov Disord. 2018 Aug;33(8):1361-1365
pubmed: 29984518
Mov Disord. 2017 Jul;32(7):995-1005
pubmed: 28500752
Mov Disord. 2019 Aug;34(8):1144-1153
pubmed: 30726566
Parkinsonism Relat Disord. 2017 Aug;41:31-36
pubmed: 28487107
Eur Radiol. 2017 Jun;27(6):2665-2675
pubmed: 27761709
J Res Med Sci. 2012 Feb;17(2):197-8
pubmed: 23264798
Mov Disord Clin Pract. 2019 Jul 24;6(6):436-439
pubmed: 31392243
Parkinsonism Relat Disord. 2016 Jan;22 Suppl 1:S34-6
pubmed: 26421392
Mov Disord. 2019 Aug;34(8):1228-1232
pubmed: 30884545
Parkinsonism Relat Disord. 2019 Dec;69:34-39
pubmed: 31665686