Distinct genetic architectures and environmental factors associate with host response to the γ2-herpesvirus infections.
Adolescent
Adult
Antibodies, Viral
/ biosynthesis
Antigens, Viral
/ genetics
Capsid Proteins
/ genetics
Coinfection
Disease Resistance
/ genetics
Epstein-Barr Virus Infections
/ epidemiology
Epstein-Barr Virus Nuclear Antigens
/ genetics
Female
Gene Expression
Genome-Wide Association Study
HIV
/ genetics
HLA-DQ alpha-Chains
/ genetics
Henipavirus Infections
/ epidemiology
Herpesvirus 4, Human
/ genetics
Herpesvirus 8, Human
/ genetics
Host-Pathogen Interactions
/ genetics
Humans
Incidence
Male
Middle Aged
Rural Population
Sarcoma, Kaposi
/ epidemiology
Uganda
/ epidemiology
Urban Population
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
31 07 2020
31 07 2020
Historique:
received:
02
11
2019
accepted:
13
07
2020
entrez:
2
8
2020
pubmed:
2
8
2020
medline:
10
9
2020
Statut:
epublish
Résumé
Kaposi's sarcoma-associated herpesvirus (KSHV) and Epstein-Barr Virus (EBV) establish life-long infections and are associated with malignancies. Striking geographic variation in incidence and the fact that virus alone is insufficient to cause disease, suggests other co-factors are involved. Here we present epidemiological analysis and genome-wide association study (GWAS) in 4365 individuals from an African population cohort, to assess the influence of host genetic and non-genetic factors on virus antibody responses. EBV/KSHV co-infection (OR = 5.71(1.58-7.12)), HIV positivity (OR = 2.22(1.32-3.73)) and living in a more rural area (OR = 1.38(1.01-1.89)) are strongly associated with immunogenicity. GWAS reveals associations with KSHV antibody response in the HLA-B/C region (p = 6.64 × 10
Identifiants
pubmed: 32737300
doi: 10.1038/s41467-020-17696-2
pii: 10.1038/s41467-020-17696-2
pmc: PMC7395761
doi:
Substances chimiques
Antibodies, Viral
0
Antigens, Viral
0
Capsid Proteins
0
Epstein-Barr Virus Nuclear Antigens
0
Epstein-Barr viral capsid antigen
0
HLA-DQ alpha-Chains
0
HLA-DQA1 antigen
0
EBV-encoded nuclear antigen 1
O5GA75RST7
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3849Subventions
Organisme : Medical Research Council
ID : MR/S003711/2
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : 75N91019D00024
Pays : United States
Organisme : Medical Research Council
ID : MR/S003711/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : WT090132
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : CCR NIH HHS
ID : HHSN261200800001C
Pays : United States
Organisme : NCI NIH HHS
ID : HHSN261200800001E
Pays : United States
Organisme : Wellcome Trust
ID : WT098051
Pays : United Kingdom
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