Reliability and availability of granger causality density in localization of Rolandic focus in BECTS.
Benign epilepsy with centrotemporal spikes
Effective connectivity
Granger causality density
Localization
Rolandic focus
Rolandic epilepsy
Journal
Brain imaging and behavior
ISSN: 1931-7565
Titre abrégé: Brain Imaging Behav
Pays: United States
ID NLM: 101300405
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
pubmed:
2
8
2020
medline:
21
7
2021
entrez:
2
8
2020
Statut:
ppublish
Résumé
A new method, called granger causality density (GCD), could reflect the directed information flow of the epileptiform activity, which is much closely match with excitatory and inhibitory imbalance theory of epilepsy. Here, we investigated if GCD could effectively localize the Rolandic focus in 50 patients with benign childhood epilepsy with central-temporal spikes (BECTS) from 27 normal children. The BECTS were classified into ictal epileptiform discharges (IEDs; 12 females, 15 males;age, 8.15 ± 1.68 years) and non-IEDs (10 females, 13 males; age, 9.09 ± 1.98 years) subgroups depending on the presence of central-temporal spikes. Multiple correlation-modality analyses (Pearson, across-voxel and across-subject correlations) were used to calculate the couplings between the GCD maps and IEDs-related brain activation map. The individual lateralization coefficient of localize IEDs and multiple regression analysis were used to identify the reliability of the GCD method in localizing the Rolandic focus. In this study, multiple correlation-modality analyses showed that the IEDs-related brain activation map and the GCD maps had highly temporal (coefficient ׀r\= 0.56 ~ 0.65) and spatial (\r\=0.53~0.91) (r\=~ couplings. The proposed GCD method and multiple regression analyses showed consistent findings with the clinical EEG recordings in lateralization of Rolandic focus. Furthermore, the GCD method could reflect the epilepsy-related brain activity during non-IEDs substate. Therefore, the proposed GCD method has the potential to be served as an effective and reliable neuroimaging biomarker to localize the Rolandic focus of BECTS. These findings are critical for clinical early diagnosis, and may promote the progression of treatment and management of pediatric epilepsy.
Identifiants
pubmed: 32737823
doi: 10.1007/s11682-020-00352-0
pii: 10.1007/s11682-020-00352-0
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1542-1552Subventions
Organisme : National Natural Science Foundation of China
ID : 81701678
Organisme : Guangdong Basic and Applied Basic Research Foundation
ID : 2020A1515011469
Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2020. Springer Science+Business Media, LLC, part of Springer Nature.
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