Anxiety and depression in COVID-19 survivors: Role of inflammatory and clinical predictors.
Adolescent
Adult
Aged
Aged, 80 and over
Anxiety
/ epidemiology
Anxiety Disorders
/ epidemiology
Betacoronavirus
C-Reactive Protein
/ immunology
COVID-19
Coronavirus Infections
/ epidemiology
Depression
/ epidemiology
Depressive Disorder
/ epidemiology
Depressive Disorder, Major
/ epidemiology
Emergency Service, Hospital
Female
Humans
Inflammation
Italy
/ epidemiology
Length of Stay
/ statistics & numerical data
Leukocyte Count
Lymphocyte Count
Male
Mental Disorders
/ epidemiology
Middle Aged
Monocytes
Neutrophils
Obsessive-Compulsive Disorder
/ epidemiology
Pandemics
Pneumonia, Viral
/ epidemiology
SARS-CoV-2
Severity of Illness Index
Sex Factors
Sleep Initiation and Maintenance Disorders
/ epidemiology
Stress Disorders, Post-Traumatic
/ epidemiology
Suicidal Ideation
Survivors
/ psychology
Young Adult
Anxiety
COVID-19
COVID-19 survivors
Depression
Inflammation
Insomnia
Mental health
Obsessive-compulsive disorder
PTSD
Psychopathology
Journal
Brain, behavior, and immunity
ISSN: 1090-2139
Titre abrégé: Brain Behav Immun
Pays: Netherlands
ID NLM: 8800478
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
10
07
2020
revised:
24
07
2020
accepted:
27
07
2020
pubmed:
2
8
2020
medline:
23
10
2020
entrez:
2
8
2020
Statut:
ppublish
Résumé
Infection-triggered perturbation of the immune system could induce psychopathology, and psychiatric sequelae were observed after previous coronavirus outbreaks. The spreading of the Severe Acute Respiratory Syndrome Coronavirus (COVID-19) pandemic could be associated with psychiatric implications. We investigated the psychopathological impact of COVID-19 in survivors, also considering the effect of clinical and inflammatory predictors. We screened for psychiatric symptoms 402 adults surviving COVID-19 (265 male, mean age 58), at one month follow-up after hospital treatment. A clinical interview and a battery of self-report questionnaires were used to investigate post-traumatic stress disorder (PTSD), depression, anxiety, insomnia, and obsessive-compulsive (OC) symptomatology. We collected sociodemographic information, clinical data, baseline inflammatory markers and follow-up oxygen saturation levels. A significant proportion of patients self-rated in the psychopathological range: 28% for PTSD, 31% for depression, 42% for anxiety, 20% for OC symptoms, and 40% for insomnia. Overall, 56% scored in the pathological range in at least one clinical dimension. Despite significantly lower levels of baseline inflammatory markers, females suffered more for both anxiety and depression. Patients with a positive previous psychiatric diagnosis showed increased scores on most psychopathological measures, with similar baseline inflammation. Baseline systemic immune-inflammation index (SII), which reflects the immune response and systemic inflammation based on peripheral lymphocyte, neutrophil, and platelet counts, positively associated with scores of depression and anxiety at follow-up. PTSD, major depression, and anxiety, are all high-burden non-communicable conditions associated with years of life lived with disability. Considering the alarming impact of COVID-19 infection on mental health, the current insights on inflammation in psychiatry, and the present observation of worse inflammation leading to worse depression, we recommend to assess psychopathology of COVID-19 survivors and to deepen research on inflammatory biomarkers, in order to diagnose and treat emergent psychiatric conditions.
Identifiants
pubmed: 32738287
pii: S0889-1591(20)31606-8
doi: 10.1016/j.bbi.2020.07.037
pmc: PMC7390748
pii:
doi:
Substances chimiques
C-Reactive Protein
9007-41-4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
594-600Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Références
Brain Behav Immun. 2020 Oct;89:531-542
pubmed: 32485289
Viruses. 2019 Dec 20;12(1):
pubmed: 31861926
Front Med (Lausanne). 2020 Jun 09;7:301
pubmed: 32582743
Psychol Assess. 2002 Dec;14(4):485-96
pubmed: 12501574
Am J Psychiatry. 2014 Apr;171(4):453-62
pubmed: 24434956
Virus Res. 2008 Apr;133(1):13-9
pubmed: 17374415
J Neuroinflammation. 2013 Apr 01;10:43
pubmed: 23547920
Psychiatry (Edgmont). 2007 May;4(5):35-40
pubmed: 20806028
Psychiatry Res. 2020 Feb 28;286:112902
pubmed: 32146248
Public Health. 2017 Nov;152:157-171
pubmed: 28915435
Acta Psychiatr Scand. 2017 May;135(5):373-387
pubmed: 28122130
Arch Gen Psychiatry. 1965 Jan;12:63-70
pubmed: 14221692
Arch Intern Med. 2009 Dec 14;169(22):2142-7
pubmed: 20008700
Psychol Assess. 2003 Jun;15(2):137-48
pubmed: 12847774
J Virol. 2008 Aug;82(15):7264-75
pubmed: 18495771
Neuroimmunomodulation. 2014;21(2-3):152-8
pubmed: 24557049
Front Cell Neurosci. 2018 Oct 26;12:386
pubmed: 30416428
Eur Psychiatry. 2005 May;20(3):236-42
pubmed: 15935422
Lancet Psychiatry. 2016 May;3(5):472-80
pubmed: 27150382
Biol Psychiatry. 2011 Oct 1;70(7):663-71
pubmed: 21641581
J Clin Psychol. 1984 Nov;40(6):1365-7
pubmed: 6511949
Cad Saude Publica. 2020 Apr 30;36(4):e00054020
pubmed: 32374806
Brain Behav Immun. 2020 Aug;88:901-907
pubmed: 32437915
Behav Res Ther. 2003 Dec;41(12):1489-96
pubmed: 14705607
J Affect Disord. 2011 Apr;130(1-2):220-5
pubmed: 21030090
Psychiatry Res. 2020 Jun;288:112966
pubmed: 32334276
Brain Behav Immun. 2020 Jul;87:34-39
pubmed: 32298803
Mol Cell Neurosci. 2013 Mar;53:52-62
pubmed: 23064447
Physiol Rev. 2018 Jan 1;98(1):477-504
pubmed: 29351513
Lancet Psychiatry. 2020 Jul;7(7):611-627
pubmed: 32437679
Psychol Med. 2004 Oct;34(7):1187-95
pubmed: 15697045
Nat Rev Immunol. 2016 Jan;16(1):22-34
pubmed: 26711676
Semin Immunopathol. 2017 Jul;39(5):529-539
pubmed: 28466096
J Pers Assess. 2008 May;90(3):280-5
pubmed: 18444124
Psychiatry Res Neuroimaging. 2019 Mar 30;285:64-66
pubmed: 30785023
Sleep Med. 2005 Jan;6(1):41-4
pubmed: 15680294
Lancet Psychiatry. 2020 Jul;7(7):570-572
pubmed: 32563299
J Clin Psychiatry. 2017 Sep/Oct;78(8):e986-e993
pubmed: 28922589
J Infect. 2020 Jun;80(6):607-613
pubmed: 32283152
Lancet. 2020 Feb 15;395(10223):497-506
pubmed: 31986264
Brain Behav Immun. 2020 Jul;87:18-22
pubmed: 32240762
J Nerv Ment Dis. 2016 Feb;204(2):108-15
pubmed: 26669984
Front Psychiatry. 2019 Jul 09;10:458
pubmed: 31354538
Sci Rep. 2019 Mar 1;9(1):3284
pubmed: 30824727
Pharmacol Ther. 2011 May;130(2):226-38
pubmed: 21334376
Brain Behav Immun. 2020 Jul;87:40-48
pubmed: 32298802
Front Psychiatry. 2020 Feb 26;11:71
pubmed: 32174850
Depress Anxiety. 2018 Nov;35(11):1081-1094
pubmed: 30199144
Lancet. 2020 Mar 14;395(10227):912-920
pubmed: 32112714
Neuropsychiatr Dis Treat. 2020 Jan 09;16:81-86
pubmed: 32021201
Lancet. 2003 Apr 19;361(9366):1319-25
pubmed: 12711465