Myricetin bioactive effects: moving from preclinical evidence to potential clinical applications.

Anti-Infective Agents / chemistry Antineoplastic Agents / chemistry Antioxidants / chemistry Dietary Supplements Flavonoids / chemistry Humans Hypoglycemic Agents / chemistry Molecular Structure Neuroprotective Agents / chemistry
Antimicrobial Antioxidant Cancer Cardiovascular disease Diabetes Immunomodulatory Myricetin Neuroprotection

Journal

BMC complementary medicine and therapies
ISSN: 2662-7671
Titre abrégé: BMC Complement Med Ther
Pays: England
ID NLM: 101761232

Informations de publication

Date de publication:
01 Aug 2020
Historique:
received: 21 03 2020
accepted: 24 07 2020
entrez: 3 8 2020
pubmed: 3 8 2020
medline: 23 1 2021
Statut: epublish

Résumé

Several flavonoids have been recognized as nutraceuticals, and myricetin is a good example. Myricetin is commonly found in plants and their antimicrobial and antioxidant activities is well demonstrated. One of its beneficial biological effects is the neuroprotective activity, showing preclinical activities on Alzheimer, Parkinson, and Huntington diseases, and even in amyotrophic lateral sclerosis. Also, myricetin has revealed other biological activities, among them as antidiabetic, anticancer, immunomodulatory, cardiovascular, analgesic and antihypertensive. However, few clinical trials have been performed using myricetin as nutraceutical. Thus, this review provides new insights on myricetin preclinical pharmacological activities, and role in selected clinical trials.

Identifiants

DOI: 10.1186/s12906-020-03033-z PMID: 32738903 PMC: PMC7395214
pubmed: 32738903
doi: 10.1186/s12906-020-03033-z
pii: 10.1186/s12906-020-03033-z
pmc: PMC7395214
doi:

Substances chimiques

Anti-Infective Agents 0
Antineoplastic Agents 0
Antioxidants 0
Flavonoids 0
Hypoglycemic Agents 0
Neuroprotective Agents 0
myricetin 76XC01FTOJ

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

241

Références

Int J Mol Sci. 2018 Aug 10;19(8):
pubmed: 30103451
Pharm Biol. 2013 Aug;51(8):1026-34
pubmed: 23767410
Rev Bras Hematol Hemoter. 2013;35(1):52-5
pubmed: 23580885
Redox Rep. 2011;16(6):242-7
pubmed: 22195992
Carbohydr Polym. 2014 Sep 22;110:329-37
pubmed: 24906763
Pharmazie. 2014 Jan;69(1):19-26
pubmed: 24601218
Antimicrob Agents Chemother. 2015 Jan;59(1):633-41
pubmed: 25403660
Arch Pharm Res. 2007 Sep;30(9):1075-9
pubmed: 17958323
Biochim Biophys Acta. 2008 Oct;1781(10):601-9
pubmed: 18662803
Arch Pharm Res. 2009 Apr;32(4):527-33
pubmed: 19407970
Int J Oncol. 2015 Oct;47(4):1494-502
pubmed: 26315556
Food Chem. 2012 Dec 15;135(4):2702-7
pubmed: 22980861
J Nutr Sci Vitaminol (Tokyo). 2006 Apr;52(2):149-53
pubmed: 16802696
Eur J Biochem. 1990 Jul 5;190(3):469-76
pubmed: 1695572
Food Chem. 2016 Dec 15;213:284-295
pubmed: 27451183
Nat Prod Res. 2011 Sep;25(16):1549-59
pubmed: 21391110
J Med Food. 2013 Mar;16(3):211-5
pubmed: 23444965
Psychopharmacology (Berl). 2018 Jan;235(1):233-244
pubmed: 29058041
Biochem Pharmacol. 2006 Mar 14;71(6):735-41
pubmed: 16414027
Electrophoresis. 2012 Nov;33(22):3380-6
pubmed: 22961751
Phytother Res. 2001 Feb;15(1):39-43
pubmed: 11180521
Eur J Pain. 2010 Nov;14(10):992-8
pubmed: 20471878
Nature. 2001 Dec 13;414(6865):799-806
pubmed: 11742412
Phytother Res. 2009 Oct;23(10):1361-6
pubmed: 19306480
J Agric Food Chem. 2000 Oct;48(10):4744-8
pubmed: 11052728
Annu Rev Nutr. 2002;22:19-34
pubmed: 12055336
Eur J Med Chem. 2019 Jul 15;174:9-15
pubmed: 31022552
Br J Nutr. 2016 Feb 14;115(3):480-9
pubmed: 26489826
Pharm Biol. 2010 May;48(5):494-8
pubmed: 20645789
Int J Mol Sci. 2015 Nov 30;16(12):28377-85
pubmed: 26633366
FASEB J. 2017 Jun;31(6):2603-2611
pubmed: 28270518
Front Biosci (Landmark Ed). 2009 Jan 01;14(12):4658-72
pubmed: 19273380
Diabetes Metab J. 2019 Apr;43(2):192-205
pubmed: 30688049
Cell Biol Int. 2018 Aug;42(8):1069-1075
pubmed: 29745443
PLoS One. 2014 May 07;9(5):e96162
pubmed: 24805126
Br J Pharmacol. 1999 Aug;127(7):1539-44
pubmed: 10455307
Int J Mol Sci. 2017 Oct 23;18(10):
pubmed: 29065551
Mol Nutr Food Res. 2009 Nov;53(11):1452-61
pubmed: 19784998
Anticancer Res. 2014 Feb;34(2):701-6
pubmed: 24511002
Spectrochim Acta A Mol Biomol Spectrosc. 2011 Jun;79(1):282-93
pubmed: 21420896
Mol Diagn Ther. 2018 Jun;22(3):281-295
pubmed: 29560608
J Neurosci Res. 2008 Feb 1;86(2):368-77
pubmed: 17722071
J Nutr. 2005 Aug;135(8):1911-7
pubmed: 16046716
Food Chem. 2008 Jun 1;108(3):879-84
pubmed: 26065748
Sci Rep. 2019 Dec 3;9(1):18233
pubmed: 31796754
Cancer Epidemiol Biomarkers Prev. 2008 Mar;17(3):553-62
pubmed: 18349272
Am J Prev Med. 2014 Mar;46(3 Suppl 1):S7-15
pubmed: 24512933
Drug Deliv. 2019 Dec;26(1):158-167
pubmed: 30822157
Front Pharmacol. 2019 Jun 11;10:647
pubmed: 31244660
J Nat Prod. 1992 Feb;55(2):179-83
pubmed: 1378087
Bioorg Med Chem. 2016 Apr 1;24(7):1488-94
pubmed: 26922036
Environ Toxicol Pharmacol. 2010 Jan;29(1):12-8
pubmed: 21787576
Evid Based Complement Alternat Med. 2012;2012:758097
pubmed: 23258999
Food Chem Toxicol. 2011 Sep;49(9):2439-44
pubmed: 21741426
Life Sci. 2000 Aug 25;67(14):1695-705
pubmed: 11021354
Evid Based Complement Alternat Med. 2011;2011:150752
pubmed: 21785619
Plant Foods Hum Nutr. 2016 Dec;71(4):444-449
pubmed: 27787697
Food Chem. 2011 Aug 1;127(3):1186-92
pubmed: 25214112
ACS Chem Biol. 2018 Jan 19;13(1):180-188
pubmed: 29172480
Phytother Res. 2005 Jul;19(7):612-7
pubmed: 16161024
Curr Pharm Des. 2018;24(2):239-258
pubmed: 29384050
Oncol Lett. 2017 Jun;13(6):4974-4978
pubmed: 28588737
Mol Biol Res Commun. 2016 Jun;5(2):87-95
pubmed: 28097162
Genes Nutr. 2008 Dec;3(3-4):115-26
pubmed: 18937002
PLoS One. 2014 Dec 29;9(12):e115323
pubmed: 25546350
ACS Chem Neurosci. 2012 Nov 21;3(11):952-62
pubmed: 23173074
Food Chem. 2020 Feb 1;305:125437
pubmed: 31499290
Biomed Pharmacother. 2019 Aug;116:109004
pubmed: 31128404
J Agric Food Chem. 2019 Feb 13;67(6):1656-1665
pubmed: 30694659
Chembiochem. 2011 May 16;12(8):1198-201
pubmed: 21538759
FEBS Lett. 2009 Feb 4;583(3):531-41
pubmed: 19116149
Life Sci. 2015 Dec 1;142:19-25
pubmed: 26455550
Arch Pharm Res. 2005 Mar;28(3):274-9
pubmed: 15832812
Chem Soc Rev. 2014 Mar 7;43(5):1423-49
pubmed: 24305596
FEBS Lett. 2011 Apr 20;585(8):1113-20
pubmed: 21443877
Z Naturforsch C J Biosci. 2009 Sep-Oct;64(9-10):626-30
pubmed: 19957428
Mol Med Rep. 2016 Mar;13(3):2094-100
pubmed: 26782830
J Nat Prod. 2011 Jan 28;74(1):38-44
pubmed: 21141876
J Food Sci. 2007 Nov;72(9):M341-5
pubmed: 18034726
J Agric Food Chem. 2013 Aug 28;61(34):8185-90
pubmed: 23926942
J Food Sci. 2010 Jan-Feb;75(1):C28-35
pubmed: 20492146
Nutrients. 2016 Feb 16;8(2):90
pubmed: 26891321
J Cell Physiol. 2019 Nov;234(11):20900-20914
pubmed: 31004355
Z Naturforsch C J Biosci. 2008 Nov-Dec;63(11-12):801-7
pubmed: 19227826
Molecules. 2019 Jun 19;24(12):
pubmed: 31248102
Biochem Pharmacol. 1996 Feb 23;51(4):423-9
pubmed: 8619886
Mol Nutr Food Res. 2013 Mar;57(3):435-46
pubmed: 23281314
Int J Biol Sci. 2010 Sep 21;6(6):556-68
pubmed: 20941374
Planta Med. 2007 Aug;73(10):1054-60
pubmed: 17694473
Eur J Med Res. 2019 Apr 26;24(1):20
pubmed: 31027517
J Neurochem. 2006 Apr;97(1):105-15
pubmed: 16524383
Diagn Pathol. 2014 Mar 20;9:68
pubmed: 24650056
Oxid Med Cell Longev. 2015;2015:782504
pubmed: 26000072
Eur J Med Chem. 2011 Sep;46(9):4548-58
pubmed: 21824690
Plant Foods Hum Nutr. 2007 Sep;62(3):93-8
pubmed: 17597415
Neuroreport. 2007 Jul 16;18(11):1181-5
pubmed: 17589323
Nutr Metab Cardiovasc Dis. 2011 May;21(5):362-71
pubmed: 20096547
Food Chem. 2013 Oct 15;140(4):686-91
pubmed: 23692754
Georgian Med News. 2006 Dec;(141):66-72
pubmed: 17261891
Bioorg Med Chem Lett. 2012 Jun 15;22(12):4049-54
pubmed: 22578462
J Agric Food Chem. 2009 May 13;57(9):3490-9
pubmed: 19326946
J Neurochem. 2003 Oct;87(1):172-81
pubmed: 12969264
Molecules. 2017 Sep 08;22(9):
pubmed: 28885580
Int J Mol Sci. 2013 Jun 04;14(6):11895-914
pubmed: 23736695
Bioorg Med Chem. 2007 Nov 15;15(22):7203-8
pubmed: 17851081
PLoS One. 2015 May 26;10(5):e0128132
pubmed: 26010916
Ann N Y Acad Sci. 2011 Jul;1229:124-32
pubmed: 21793847
J Agric Food Chem. 2001 Jul;49(7):3274-7
pubmed: 11453762
Int J Mol Sci. 2010 Nov 02;11(11):4348-60
pubmed: 21151442
Int J Cancer. 2007 Nov 15;121(10):2225-32
pubmed: 17471564
Neural Regen Res. 2016 Dec;11(12):1976-1980
pubmed: 28197195
Carcinogenesis. 2007 Sep;28(9):1918-27
pubmed: 17693661
J Nat Prod. 1996 Oct;59(10):987-90
pubmed: 8904847
Exp Ther Med. 2019 Apr;17(4):3083-3091
pubmed: 30906480
Nitric Oxide. 2013 Feb 28;29:25-9
pubmed: 23246439
Cancer Cell Int. 2014 Jul 18;14:71
pubmed: 25788859
Clin Exp Med. 2012 Dec;12(4):265-72
pubmed: 22083509
Cell Mol Biol (Noisy-le-grand). 2018 Jun 25;64(8):57-64
pubmed: 29981684
J Asian Nat Prod Res. 2014;16(4):370-5
pubmed: 24597719
Biol Pharm Bull. 2006 Aug;29(8):1751-5
pubmed: 16880637
J Agric Food Chem. 1999 Jun;47(6):2274-9
pubmed: 10794622
Neuropharmacology. 2011 Jul-Aug;61(1-2):329-35
pubmed: 21549720
Nutr Cancer. 2012;64(4):599-606
pubmed: 22482362
Jpn J Clin Oncol. 2009 Jun;39(6):352-9
pubmed: 19351659
Planta Med. 2006 Jun;72(7):604-10
pubmed: 16636967
Am J Clin Nutr. 2002 Sep;76(3):560-8
pubmed: 12198000
J Ayurveda Integr Med. 2015 Jul-Sep;6(3):165-74
pubmed: 26604551

Auteurs

Yasaman Taheri (Y)

Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Pharmacology and Toxicology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Hafiz Ansar Rasul Suleria (HAR)

Department of Agriculture and Food Systems, The University of Melbourne, Melbourne, Australia.

Natália Martins (N)

Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, 4200-319, Porto, Portugal.
Institute for Research and Innovation in Health (i3S), University of Porto, 4200-135, Porto, Portugal.

Oksana Sytar (O)

Department of Plant Biology Department, Taras Shevchenko National University of Kyiv, Institute of Biology, Volodymyrska str., 64, Kyiv, 01033, Ukraine.
Department of Plant Physiology, Slovak University of Agriculture, Nitra, A. Hlinku 2, 94976, Nitra, Slovak Republic.

Ahmet Beyatli (A)

Department of Medicinal and Aromatic Plants, University of Health Sciences, 34668, Istanbul, Turkey.

Balakyz Yeskaliyeva (B)

Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty, Kazakhstan.

Gulnaz Seitimova (G)

Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty, Kazakhstan.

Bahare Salehi (B)

Noncommunicable Diseases Research Center, Bam University of Medical Sciences, Bam, Iran. bahar.salehi007@gmail.com.
Student Research Committee, School of Medicine, Bam University of Medical Sciences, Bam, Iran. bahar.salehi007@gmail.com.

Prabhakar Semwal (P)

Department of Biotechnology, Graphic Era University, Dehradun, Uttarakhand, 248001, India. semwal.prabahakar@gmail.com.
Uttarakhand State Council for Science and Technology, Vigyan Dham, Dehradun, Uttarakhand, 248007, India. semwal.prabahakar@gmail.com.

Sakshi Painuli (S)

Department of Biotechnology, Graphic Era University, Dehradun, Uttarakhand, 248001, India.
Himalayan Environmental Studies and Conservation Organization, Prem Nagar, Dehradun, Uttarakhand, 248001, India.

Anuj Kumar (A)

Uttarakhand Council for Biotechnology, Silk Park, Prem Nagar, Dehradun, Uttarakhand, 248007, India.

Elena Azzini (E)

CREA-Research Centre for Food and Nutrition, Via Ardeatina 546, 00178, Rome, Italy.

Miquel Martorell (M)

Department of Nutrition and Dietetics, Faculty of Pharmacy, and Centre for Healthy Living, University of Concepción, 4070386, Concepción, Chile. martorellpons@gmail.com.
Unidad de Desarrollo Tecnológico, UDT, Universidad de Concepción, 4070386, Concepción, Chile. martorellpons@gmail.com.

William N Setzer (WN)

Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL, 35899, USA.
Aromatic Plant Research Center, 230 N 1200 E, Suite 100, Lehi, UT, 84043, USA.

Alfred Maroyi (A)

Department of Botany, University of Fort Hare, Private Bag X1314, Alice, 5700, South Africa. amaroyi@ufh.ac.za.

Javad Sharifi-Rad (J)

Zabol Medicinal Plants Research Center, Zabol University of Medical Sciences, Zabol, Iran. javad.sharifirad@gmail.com.
ORCID: 0000-0002-7301-8151

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Myricetin bioactive effects: moving from...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Myricetin bioactive effects: moving from...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents protecteurs › Antioxydants › Myricetin bioactive effects: moving from...
questionsmedicales.fr › Aliments et boissons › Aliments › Compléments alimentaires › Myricetin bioactive effects: moving from...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › 4H-1-Benzopyran-4-ones › Flavonoïdes › Myricetin bioactive effects: moving from...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Myricetin bioactive effects: moving from...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hypoglycémiants › Myricetin bioactive effects: moving from...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Myricetin bioactive effects: moving from...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Neuroprotecteurs › Myricetin bioactive effects: moving from...