Iron and cardiovascular diseases.

Atherosclerosis / blood Cardiovascular Diseases / blood Heart Failure / blood Humans Iron / blood Iron Deficiencies Iron Overload / blood Oxidative Stress
Atherosclerosis Heart failure Iron Transferrin receptor 1

Journal

Journal of cardiology
ISSN: 1876-4738
Titre abrégé: J Cardiol
Pays: Netherlands
ID NLM: 8804703

Informations de publication

Date de publication:
02 2021
Historique:
received: 23 06 2020
accepted: 24 06 2020
pubmed: 3 8 2020
medline: 24 7 2021
entrez: 3 8 2020
Statut: ppublish

Résumé

Iron is a necessary element for life; however, excess iron leads to oxidative stress by the Fenton reaction. Iron deficiency is prevalent in patients with heart failure, while iron overload is associated in the pathogenesis of atherosclerosis. These findings suggest the "iron paradox" in cardiovascular diseases. Iron metabolism in cardiovascular diseases is complex, and the mechanisms regulating systemic and cellular iron metabolism in cardiovascular diseases remain completely unknown. In this review, we focus on the role of iron in cardiovascular diseases.

Identifiants

DOI: 10.1016/j.jjcc.2020.07.009 PMID: 32739111
pubmed: 32739111
pii: S0914-5087(20)30250-1
doi: 10.1016/j.jjcc.2020.07.009
pii:
doi:

Substances chimiques

Iron E1UOL152H7

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

160-165

Informations de copyright

Copyright © 2020 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.

Auteurs

Yoshiro Naito (Y)

Department of Cardiovascular and Renal Medicine, Hyogo College of Medicine, Nishinomiya, Japan. Electronic address: ynaito@hyo-med.ac.jp.

Tohru Masuyama (T)

Japan Community Health care Organization, Hoshigaoka Medical Center, Hirakata, Japan.

Masaharu Ishihara (M)

Department of Cardiovascular and Renal Medicine, Hyogo College of Medicine, Nishinomiya, Japan.

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Classifications MeSH

questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Artériopathies oblitérantes › Artériosclérose › Athérosclérose › Iron and cardiovascular diseases.
questionsmedicales.fr › Maladies cardiovasculaires › Iron and cardiovascular diseases.
questionsmedicales.fr › Maladies cardiovasculaires › Cardiopathies › Défaillance cardiaque › Iron and cardiovascular diseases.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Iron and cardiovascular diseases.
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Fer › Iron and cardiovascular diseases.
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Troubles du métabolisme du fer › Carences en fer › Iron and cardiovascular diseases.
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Troubles du métabolisme du fer › Surcharge en fer › Iron and cardiovascular diseases.
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › Iron and cardiovascular diseases.