Anabolic steroid excess promotes hydroelectrolytic and autonomic imbalance in adult male rats: Is it enough to alter blood pressure?
Anabolic Agents
/ pharmacology
Animals
Autonomic Nervous System
/ drug effects
Blood Pressure
/ drug effects
Gene Expression Regulation
/ drug effects
Hypothalamus
/ drug effects
Kidney
/ drug effects
Male
Mineralocorticoids
/ genetics
Nandrolone Decanoate
/ pharmacology
RNA, Messenger
/ genetics
Rats
Rats, Wistar
Receptor, Angiotensin, Type 1
/ genetics
Renin
/ genetics
Anabolic steroids
Angiotensin II
Autonomic imbalance
Blood pressure
Hydroelectrolytic imbalance
Vascular reactivity
Journal
Steroids
ISSN: 1878-5867
Titre abrégé: Steroids
Pays: United States
ID NLM: 0404536
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
07
04
2020
revised:
20
07
2020
accepted:
27
07
2020
pubmed:
3
8
2020
medline:
20
7
2021
entrez:
3
8
2020
Statut:
ppublish
Résumé
The present study investigated the effects of anabolic steroid (AS) excess on blood pressure regulation. Male Wistar rats were treated with nandrolone decanoate (AS) or vehicle (CTL) for 8 or 10 weeks. Saline (1.8%) and water intake were measured in metabolic cages. Urinary volume, osmolarity, Na AS group exhibited decreased urinary volume and Na AS excess promoted hydroelectrolytic and autonomic imbalance but did not alter vascular or cardiac function/morphology.
Identifiants
pubmed: 32739291
pii: S0039-128X(20)30137-9
doi: 10.1016/j.steroids.2020.108711
pii:
doi:
Substances chimiques
Anabolic Agents
0
Mineralocorticoids
0
RNA, Messenger
0
Receptor, Angiotensin, Type 1
0
Renin
EC 3.4.23.15
Nandrolone Decanoate
H45187T098
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
108711Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.