Anti-Acanthamoeba disinfection: hands, surfaces and wounds.
Acanthamoeba
/ drug effects
Acanthamoeba Keratitis
/ parasitology
Alcohols
/ pharmacology
Antiparasitic Agents
/ pharmacology
Disinfectants
/ pharmacology
Disinfection
Hand Disinfection
Humans
Imines
Peracetic Acid
/ pharmacology
Pyridines
/ pharmacology
Quaternary Ammonium Compounds
/ pharmacology
Sulfuric Acids
/ pharmacology
Trophozoites
/ drug effects
Acanthamoeba
Antiseptics
Disinfection
Octenidine dihydrochloride
Polyhexanide
Quaternary ammonium compounds
Journal
International journal of antimicrobial agents
ISSN: 1872-7913
Titre abrégé: Int J Antimicrob Agents
Pays: Netherlands
ID NLM: 9111860
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
23
04
2020
revised:
16
07
2020
accepted:
23
07
2020
pubmed:
3
8
2020
medline:
28
5
2021
entrez:
3
8
2020
Statut:
ppublish
Résumé
Acanthamoebae are facultative parasites causing rare but serious infections such as keratitis and encephalitis and are also known as vectors for several bacterial pathogens, including legionellae and pseudomonads. Acanthamoeba cysts are particularly resilient and enable the amoebae to withstand desiccation and to resist disinfection and therapy. While the search for new therapeutic options has been intensified in the past years, hand and surface disinfectants as well as topical antiseptics for preventing infections have not been studied in detail to date. The aim of this study was to screen well-known and commonly used antimicrobial products in various formulations and different concentrations for their efficacy against Acanthamoeba trophozoites and cysts, including aliphatic alcohols, quaternary ammonium compounds (QACs), peracetic acid (PAA), potassium peroxymonosulfate sulfate (PPMS) and octenidine dihydrochloride (OCT). Of all products tested, OCT and QACs showed the highest efficacy, totally eradicating both trophozoites and cysts within 1 min. The determined 50% effective concentration (EC
Identifiants
pubmed: 32739477
pii: S0924-8579(20)30305-8
doi: 10.1016/j.ijantimicag.2020.106122
pii:
doi:
Substances chimiques
Alcohols
0
Antiparasitic Agents
0
Disinfectants
0
Imines
0
Pyridines
0
Quaternary Ammonium Compounds
0
Sulfuric Acids
0
potassium peroxymonosulfuric acid
HL6A2XXU5D
Peracetic Acid
I6KPI2E1HD
octenidine
OZE0372S5A
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
106122Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.