Nanosized zeolites as a gas delivery platform in a glioblastoma model.
Glioblastoma
Hypoxia
MRI
Nanosized zeolites
Vectorization
Journal
Biomaterials
ISSN: 1878-5905
Titre abrégé: Biomaterials
Pays: Netherlands
ID NLM: 8100316
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
20
04
2020
revised:
14
07
2020
accepted:
17
07
2020
pubmed:
3
8
2020
medline:
15
5
2021
entrez:
3
8
2020
Statut:
ppublish
Résumé
Approaches able to counteract, at least temporarily, hypoxia, a well-known factor of resistance to treatment in solid tumors are highly desirable. Herein, we report the use of nanosized zeolite crystals as hyperoxic/hypercapnic gas carriers for glioblastoma. First, the non-toxic profile of nanosized zeolite crystals in living animals (mice, rats and non-human primates) and in various cell types is presented. Second, the ability of the nanosized zeolites to act as a vasoactive agent for a targeted re-oxygenation of the tumor after intravenous injection is shown. As attested by an MRI protocol, the zeolites were able to increase oxygenation and blood volume specifically within the brain tumor whilst no changes in the healthy-non tumoral brain-were observed. The first proof of concept for the use of metal-containing nanosized zeolites as a tool for vectorization of hyperoxic/hypercapnic gases in glioblastoma is revealed.
Identifiants
pubmed: 32739663
pii: S0142-9612(20)30495-6
doi: 10.1016/j.biomaterials.2020.120249
pii:
doi:
Substances chimiques
Gases
0
Zeolites
1318-02-1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
120249Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.