Effects of IgLON5 Antibodies on Neuronal Cytoskeleton: A Link between Autoimmunity and Neurodegeneration.
Animals
Antibodies
/ pharmacology
Autoimmune Diseases
/ immunology
Axons
/ pathology
Cell Adhesion Molecules, Neuronal
/ immunology
Cells, Cultured
Cytoskeleton
/ drug effects
HEK293 Cells
Hippocampus
/ cytology
Humans
Immunoglobulin G
/ immunology
Neurites
/ pathology
Neurodegenerative Diseases
/ immunology
Neurofilament Proteins
/ cerebrospinal fluid
Neurons
/ drug effects
Rats
Journal
Annals of neurology
ISSN: 1531-8249
Titre abrégé: Ann Neurol
Pays: United States
ID NLM: 7707449
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
08
05
2020
revised:
28
07
2020
accepted:
29
07
2020
pubmed:
3
8
2020
medline:
15
12
2020
entrez:
3
8
2020
Statut:
ppublish
Résumé
Anti-IgLON5 disease is a neurological disorder characterized by autoantibodies against IgLON5 and pathological evidence of neuronal-specific tau accumulation. Here, we report that patients' IgLON5 IgG, but not other cell-surface antibodies, disrupt the cytoskeletal organization in cultured rat hippocampal neurons, resulting in dystrophic neurites and axonal swelling. Adsorption of IgLON5 IgG with HEK293 cells expressing IgLON5 abrogated the indicated cytoskeletal changes. These findings, along with an increase of levels of neurofilaments in patients' cerebrospinal fluid, suggest that IgLON5 IgG, unlike other cell-surface antibodies, disrupts neuronal cytoskeleton maintenance, providing a link between autoimmunity and neurodegeneration. ANN NEUROL 2020;88:1023-1027.
Substances chimiques
Antibodies
0
Cell Adhesion Molecules, Neuronal
0
IgLON5 protein, human
0
Immunoglobulin G
0
Neurofilament Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1023-1027Informations de copyright
© 2020 American Neurological Association.
Références
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