Nelson's Syndrome: An Update.

ACTH-Secreting Pituitary Adenoma / complications Adenoma / complications Endocrinology / methods Humans Medical Oncology / methods Nelson Syndrome / diagnosis Pituitary ACTH Hypersecretion / diagnosis
Bilateral adrenalectomy Corticotroph tumor progression Cushing’s Nelson’s syndrome Tumor growth

Journal

Endocrinology and metabolism clinics of North America
ISSN: 1558-4410
Titre abrégé: Endocrinol Metab Clin North Am
Pays: United States
ID NLM: 8800104

Informations de publication

Date de publication:
09 2020
Historique:
entrez: 4 8 2020
pubmed: 4 8 2020
medline: 22 6 2021
Statut: ppublish

Résumé

Nelson's syndrome (NS) is a condition which may develop in patients with Cushing's disease after bilateral adrenalectomy. Although there is no formal consensus on what defines NS, corticotroph tumor growth and/or gradually increasing ACTH levels are important diagnostic elements. Pathogenesis is unclear and well-established predictive factors are lacking; high ACTH during the first year after bilateral adrenalectomy is the most consistently reported predictive parameter. Management is individualized and includes surgery, with or without radiotherapy, radiotherapy alone, and observation; medical treatments have shown inconsistent results. A subset of tumors demonstrates aggressive behavior with challenging management, malignant transformation and poor prognosis.

Identifiants

DOI: 10.1016/j.ecl.2020.05.004 PMID: 32741480
pubmed: 32741480
pii: S0889-8529(20)30031-1
doi: 10.1016/j.ecl.2020.05.004
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

413-432

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Disclosure The authors have nothing to disclose. This work did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.

Auteurs

Athanasios Fountas (A)

Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, IBR Tower, Level 2, Birmingham, B15 2TT, UK; Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, B15 2TH, UK; Department of Endocrinology, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust, Birmingham, B15 2TH, UK.

Niki Karavitaki (N)

Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, IBR Tower, Level 2, Birmingham, B15 2TT, UK; Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, B15 2TH, UK; Department of Endocrinology, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust, Birmingham, B15 2TH, UK. Electronic address: n.karavitaki@bham.ac.uk.

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Classifications MeSH

questionsmedicales.fr › Maladies endocriniennes › Maladies de l'hypophyse › Tumeurs de l'hypophyse › Adénome à ACTH › Nelson's Syndrome: An Update.
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs épithéliales épidermoïdes et glandulaires › Adénomes › Nelson's Syndrome: An Update.
questionsmedicales.fr › Professions de santé › Médecine › Médecine interne › Endocrinologie › Nelson's Syndrome: An Update.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Nelson's Syndrome: An Update.
questionsmedicales.fr › Professions de santé › Médecine › Médecine interne › Oncologie médicale › Nelson's Syndrome: An Update.
questionsmedicales.fr › Maladies endocriniennes › Maladies de l'hypophyse › Tumeurs de l'hypophyse › Adénome à ACTH › Syndrome de Nelson › Nelson's Syndrome: An Update.
questionsmedicales.fr › Maladies endocriniennes › Maladies de l'hypophyse › Hyperpituitarisme › Hypersécrétion hypophysaire d'ACTH › Nelson's Syndrome: An Update.