Toll-Like Receptor 4 Inhibitor TAK-242 Augments Acetylcholine-Induced Relaxation in Superior Mesenteric Arteries of the Streptozotocin-Induced Diabetic Rat.
Acetylcholine
/ pharmacology
Animals
Diabetes Mellitus, Experimental
/ complications
Diabetic Angiopathies
/ drug therapy
Endothelium-Dependent Relaxing Factors
/ physiology
Male
Mesenteric Artery, Superior
/ drug effects
Rats
Rats, Wistar
Streptozocin
Sulfonamides
/ pharmacology
Thromboxane A2
/ biosynthesis
Toll-Like Receptor 4
/ antagonists & inhibitors
Vasodilation
/ drug effects
relaxation
streptozotocin
superior mesenteric artery
thromboxane
toll-like receptor 4
Journal
Biological & pharmaceutical bulletin
ISSN: 1347-5215
Titre abrégé: Biol Pharm Bull
Pays: Japan
ID NLM: 9311984
Informations de publication
Date de publication:
2020
2020
Historique:
entrez:
4
8
2020
pubmed:
4
8
2020
medline:
1
6
2021
Statut:
ppublish
Résumé
Although vascular dysfunction is a key event in the development of diabetic complications, and abnormal toll-like receptor 4 (TLR4) may contribute to the pathophysiology of vascular diseases, the direct relationships between TLR4 and vascular function in diabetic arteries are still poorly understood. Thus, to investigate whether pharmacological blockade of TLR4 affects vascular function in the superior mesenteric artery (SMA) of streptozotocin (STZ)-induced diabetic rats, the SMA was isolated from male Wistar rat injected once with STZ (65 mg/kg, 27-34 weeks) which was treated with TAK-242 (10
Identifiants
pubmed: 32741952
doi: 10.1248/bpb.b20-00328
doi:
Substances chimiques
Endothelium-Dependent Relaxing Factors
0
Sulfonamides
0
Toll-Like Receptor 4
0
ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate
0
Thromboxane A2
57576-52-0
Streptozocin
5W494URQ81
Acetylcholine
N9YNS0M02X
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM