Local prolonged release of antibiotic for prevention of sternal wound infections postcardiac surgery-A novel technology.
Aged
Anti-Bacterial Agents
/ administration & dosage
Antibiotic Prophylaxis
Cardiac Surgical Procedures
/ adverse effects
Delayed-Action Preparations
/ therapeutic use
Drug Liberation
Female
Humans
Male
Middle Aged
Prospective Studies
Single-Blind Method
Sternotomy
/ adverse effects
Sternum
Surgical Wound Infection
/ prevention & control
D-PLEX technology
antibiotics
cardiac surgery
sternal wound infections
Journal
Journal of cardiac surgery
ISSN: 1540-8191
Titre abrégé: J Card Surg
Pays: United States
ID NLM: 8908809
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
pubmed:
4
8
2020
medline:
1
12
2020
entrez:
4
8
2020
Statut:
ppublish
Résumé
Sternal wound infection (SWI) is a devastating postcardiac surgical complication. D-PLEX Eighty-one patients were enrolled in a prospective single-blind randomized controlled multicenter study. Sixty patients were treated with both D-PLEX and standard of care (SOC) and 21 with SOC alone. Both groups were followed 6 months for safety endpoints. SWI was assessed at 90 days. No SWI-related serious adverse events (SAEs) occurred in either group. The mean plasma C D-PLEX was found to be safe for use in cardiac surgery patients. By providing localized prophylactic prolonged release of broad-spectrum antibiotics, D-PLEX has the potential to prevent SWI postcardiac surgery and long-term postoperative hospitalization, reducing high-treatment costs, morbidity, and mortality.
Substances chimiques
Anti-Bacterial Agents
0
Delayed-Action Preparations
0
Types de publication
Journal Article
Multicenter Study
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
2695-2703Subventions
Organisme : PolyPid Ltd. Petach-Tikva, Israel
Informations de copyright
© 2020 Wiley Periodicals LLC.
Références
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