Neuronal mitochondrial calcium uniporter deficiency exacerbates axonal injury and suppresses remyelination in mice subjected to experimental autoimmune encephalomyelitis.
Adenosine Triphosphate
/ metabolism
Animals
Autophagy
/ genetics
Axons
/ pathology
Calcium Channels
/ deficiency
Encephalomyelitis, Autoimmune, Experimental
/ pathology
Gait Disorders, Neurologic
/ genetics
Gene Expression
/ genetics
Male
Mice
Mice, Knockout
Mitochondria
/ metabolism
Mitochondrial Proteins
/ deficiency
Mitochondrial Swelling
Myelin Sheath
/ pathology
Neurons
/ metabolism
Phagosomes
/ pathology
Spinal Cord
/ pathology
Autophagy
Calpain activation
Demyelination
Mitochondrial calcium uptake
Multiple sclerosis
Journal
Experimental neurology
ISSN: 1090-2430
Titre abrégé: Exp Neurol
Pays: United States
ID NLM: 0370712
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
19
05
2020
revised:
05
07
2020
accepted:
28
07
2020
pubmed:
4
8
2020
medline:
6
3
2021
entrez:
4
8
2020
Statut:
ppublish
Résumé
High-capacity mitochondrial calcium (Ca
Identifiants
pubmed: 32745471
pii: S0014-4886(20)30261-2
doi: 10.1016/j.expneurol.2020.113430
pii:
doi:
Substances chimiques
Calcium Channels
0
Mcu protein, mouse
0
Mitochondrial Proteins
0
Adenosine Triphosphate
8L70Q75FXE
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
113430Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. Authors' contributions SPH, AL, MDJF, MN and RJN assisted with the EAE studies, histology, statistical analysis and preparation of the manuscript. BEK, PK and SG performed the flow cytometry and statistical analysis of the resultant data and assisted with the preparation of the manuscript. GSR assisted with the statistical analysis and preparation of the manuscript.