Methods for quantitative susceptibility and R2* mapping in whole post-mortem brains at 7T applied to amyotrophic lateral sclerosis.
Aged
Amyotrophic Lateral Sclerosis
/ diagnostic imaging
Cerebral Cortex
/ diagnostic imaging
Diagnosis
Female
Ferritins
/ metabolism
Gyrus Cinguli
/ diagnostic imaging
Humans
Magnetic Resonance Imaging
/ methods
Male
Middle Aged
Motor Cortex
/ diagnostic imaging
Myelin Sheath
/ metabolism
Visual Cortex
/ diagnostic imaging
Amyotrophic lateral sclerosis
Ferritin
Myelin
Post-mortem
Quantitative susceptibility mapping
R2* mapping
Journal
NeuroImage
ISSN: 1095-9572
Titre abrégé: Neuroimage
Pays: United States
ID NLM: 9215515
Informations de publication
Date de publication:
15 11 2020
15 11 2020
Historique:
received:
01
05
2020
revised:
03
07
2020
accepted:
27
07
2020
pubmed:
4
8
2020
medline:
26
2
2021
entrez:
4
8
2020
Statut:
ppublish
Résumé
Susceptibility weighted magnetic resonance imaging (MRI) is sensitive to the local concentration of iron and myelin. Here, we describe a robust image processing pipeline for quantitative susceptibility mapping (QSM) and R2* mapping of fixed post-mortem, whole-brain data. Using this pipeline, we compare the resulting quantitative maps in brains from patients with amyotrophic lateral sclerosis (ALS) and controls, with validation against iron and myelin histology. Twelve post-mortem brains were scanned with a multi-echo gradient echo sequence at 7T, from which susceptibility and R2* maps were generated. Semi-quantitative histological analysis for ferritin (the principal iron storage protein) and myelin proteolipid protein was performed in the primary motor, anterior cingulate and visual cortices. Magnetic susceptibility and R2* values in primary motor cortex were higher in ALS compared to control brains. Magnetic susceptibility and R2* showed positive correlations with both myelin and ferritin estimates from histology. Four out of nine ALS brains exhibited clearly visible hyperintense susceptibility and R2* values in the primary motor cortex. Our results demonstrate the potential for MRI-histology studies in whole, fixed post-mortem brains to investigate the biophysical source of susceptibility weighted MRI signals in neurodegenerative diseases like ALS.
Identifiants
pubmed: 32745677
pii: S1053-8119(20)30702-3
doi: 10.1016/j.neuroimage.2020.117216
pmc: PMC7775972
pii:
doi:
Substances chimiques
Ferritins
9007-73-2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
117216Subventions
Organisme : Medical Research Council
ID : G1000691
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 202788/Z/16/Z
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/L022656/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K02213X/1
Pays : United Kingdom
Organisme : Department of Health
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 203139/Z/16/Z
Pays : United Kingdom
Informations de copyright
Copyright © 2020. Published by Elsevier Inc.
Déclaration de conflit d'intérêts
Declarations of Competing Interest None
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