Sleep and orexin: A new paradigm for understanding behavioural-variant frontotemporal dementia?

Brain / drug effects Frontotemporal Dementia / physiopathology Humans Impulsive Behavior Orexins / adverse effects Sleep / physiology
Behavioural-variant frontotemporal dementia Pathophysiology Sleep orexin

Journal

Sleep medicine reviews
ISSN: 1532-2955
Titre abrégé: Sleep Med Rev
Pays: England
ID NLM: 9804678

Informations de publication

Date de publication:
12 2020
Historique:
received: 10 03 2020
revised: 12 05 2020
accepted: 15 05 2020
pubmed: 4 8 2020
medline: 5 10 2021
entrez: 4 8 2020
Statut: ppublish

Résumé

Behavioural variant frontotemporal dementia (bvFTD) is a complex and heterogeneous disorder with as yet unidentified unifying pathophysiological mechanism. There is emerging evidence that hypothalamic dysfunction, manifesting as disturbances in sleep and metabolism, is an integral component of neurodegeneration in bvFTD. Although sleep and metabolic disturbances and the behavioural abnormalities of bvFTD may appear disparate on the surface, there may be a common underlying hormonal mechanism involving orexin. Orexin is a hypothalamic neurotransmitter directly responsible for control of sleep and metabolism in healthy individuals and is implicated in many abnormal behaviours commonly seen in bvFTD - such as impulsive behaviour, hedonistic reinforcement and binge-consumption of ethanol. Further characterising orexin's role in pathophysiology of bvFTD could lead to a new paradigm for understanding this disease and may provide a new direction towards effective management and treatment.

Identifiants

DOI: 10.1016/j.smrv.2020.101361 PMID: 32745956
pubmed: 32745956
pii: S1087-0792(20)30104-0
doi: 10.1016/j.smrv.2020.101361
pii:
doi:

Substances chimiques

Orexins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

101361

Informations de copyright

Crown Copyright © 2020. Published by Elsevier Ltd. All rights reserved.

Auteurs

Yun Tae Hwang (YT)

The University of Sydney, Brain and Mind Centre, 100 Mallett Street, Camperdown, NSW, 2050, Australia; Gosford Hospital, Holden Street, Gosford, NSW, 2250, Australia. Electronic address: yun.hwang@sydney.edu.au.

Olivier Piguet (O)

The University of Sydney, Brain and Mind Centre, 100 Mallett Street, Camperdown, NSW, 2050, Australia; The University of Sydney, School of Psychology, Brennan MacCallum Building A18, Manning Road, Camperdown, NSW, 2050, Australia. Electronic address: olivier.piguet@sydney.edu.au.

John R Hodges (JR)

The University of Sydney, Brain and Mind Centre, 100 Mallett Street, Camperdown, NSW, 2050, Australia. Electronic address: john.hodges@sydney.edu.au.

Ron Grunstein (R)

Centre for Sleep and Chronobiology (CIRUS), Woolcock Institute of Medical Research, 431 Glebe Point Road, Glebe, NSW, 2037, Australia; Royal Prince Alfred Hospital, 50 Missenden Road, Camperdown, NSW, 2050, Australia. Electronic address: ron.grunstein@sydney.edu.au.

James R Burrell (JR)

The University of Sydney, Brain and Mind Centre, 100 Mallett Street, Camperdown, NSW, 2050, Australia; Concord General Hospital, Hospital Road, Concord, NSW, 2139, Australia; The University of Sydney, Concord Clinical School, Medical Education Centre, Concord General Hospital, Hospital Road, Concord, NSW, 2139, Australia. Electronic address: james.burrell@sydney.edu.au.

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Classifications MeSH

questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Sleep and orexin: A new paradigm for...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Dégénérescence lobaire frontotemporale › Démence frontotemporale › Sleep and orexin: A new paradigm for...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Sleep and orexin: A new paradigm for...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Comportement › Comportement impulsif › Sleep and orexin: A new paradigm for...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Neuropeptides › Orexines › Sleep and orexin: A new paradigm for...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Sommeil › Sleep and orexin: A new paradigm for...