Risk factors for cutaneous reactions to allopurinol in Kinh Vietnamese: results from a case-control study.
Allopurinol
Gout
HLA-B*58:01
Kinh Vietnamese
Risk factors
Skin reactions
Journal
Arthritis research & therapy
ISSN: 1478-6362
Titre abrégé: Arthritis Res Ther
Pays: England
ID NLM: 101154438
Informations de publication
Date de publication:
03 08 2020
03 08 2020
Historique:
received:
21
02
2020
accepted:
20
07
2020
entrez:
5
8
2020
pubmed:
5
8
2020
medline:
22
6
2021
Statut:
epublish
Résumé
The aim of this study was to investigate risk factors for cutaneous adverse reactions (CARs) in Kinh Vietnamese. All patients were prospectively recruited in Ho Chi Minh City. Presence of the HLA-B*58:01 allele was determined by real-time PCR-sequence-specific amplification by using the PG5801 Detection Kit (Pharmigene, Taipei). Patients with severe (SCARs) and mild (MCARs) CARs and controls were compared for differences in features prospectively collected, and odds ratios (ORs) with 95% confidence intervals (CIs) were estimated. On comparing 32 patients with SCARs and 395 tolerant controls, we identified eight strong risk factors: increased age (OR 15.1 [95% CI 5.8-40.1], P < 0.0001), female sex (OR 333 [40-43,453], P < 0.0001), allopurinol for asymptomatic hyperuricemia (OR 955 [120-125,847], P < 0.0001), allopurinol starting dose > 150 mg (OR 316 [101-122], P < 0.0001), diuretics intake (OR 304 [35-40,018], P < 0.0001), eGFR < 60 ml/min/1.73 m This study confirmed 8 risk factors, including HLA-B*58:01, for SCARs and identified 3 risk factors for MCARs in Kinh Vietnamese. HLA-B*58:01 genotyping could guide the indication for allopurinol in Kinh Vietnamese patients with gout.
Identifiants
pubmed: 32746911
doi: 10.1186/s13075-020-02273-1
pii: 10.1186/s13075-020-02273-1
pmc: PMC7397637
doi:
Substances chimiques
Gout Suppressants
0
HLA-B Antigens
0
Allopurinol
63CZ7GJN5I
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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