Protective Immune Responses Elicited by Deglycosylated Live-Attenuated Simian Immunodeficiency Virus Vaccine Are Associated with IL-15 Effector Functions.
Animals
Antibodies, Viral
/ immunology
CD8-Positive T-Lymphocytes
/ immunology
Immunity, Innate
/ immunology
Interleukin-15
/ immunology
Killer Cells, Natural
/ immunology
Macaca mulatta
Male
Monocytes
/ immunology
SAIDS Vaccines
/ immunology
Signal Transduction
/ immunology
Simian Acquired Immunodeficiency Syndrome
/ immunology
Simian Immunodeficiency Virus
/ immunology
Vaccination
/ methods
Vaccines, Attenuated
/ immunology
Viral Load
/ immunology
Virus Replication
/ immunology
Journal
Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R
Informations de publication
Date de publication:
01 09 2020
01 09 2020
Historique:
received:
09
12
2019
accepted:
25
06
2020
pubmed:
5
8
2020
medline:
23
3
2021
entrez:
5
8
2020
Statut:
ppublish
Résumé
Deglycosylated, live-attenuated SIV vaccines elicited protective immune responses against heterologous SIVsmE543-3, which differs from the vaccine strain SIVmac239 to levels similar to those across HIV-1 clades. Two thirds of the vaccinees contained the chronic SIVsmE543-3 infection (controllers), whereas one third did not (noncontrollers). In this study, we investigated immune correlates of heterologous challenge control in rhesus macaques of Burmese origin. Because depletion of CD8
Identifiants
pubmed: 32747501
pii: jimmunol.1901431
doi: 10.4049/jimmunol.1901431
pmc: PMC7484436
mid: NIHMS1609168
doi:
Substances chimiques
Antibodies, Viral
0
Interleukin-15
0
SAIDS Vaccines
0
Vaccines, Attenuated
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1331-1344Subventions
Organisme : NIAID NIH HHS
ID : R01 AI111907
Pays : United States
Organisme : NIH HHS
ID : R24 OD010947
Pays : United States
Informations de copyright
Copyright © 2020 by The American Association of Immunologists, Inc.
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