Posttransplant Cyclophosphamide and Antithymocyte Globulin versus Posttransplant Cyclophosphamide as Graft-versus-Host Disease Prophylaxis for Peripheral Blood Stem Cell Haploidentical Transplants: Comparison of T Cell and NK Effector Reconstitution.
Adult
Aged
Antilymphocyte Serum
/ therapeutic use
CD3 Complex
/ metabolism
Cyclophosphamide
/ therapeutic use
Female
Graft vs Host Disease
/ drug therapy
Hematopoietic Stem Cell Transplantation
/ adverse effects
Humans
Immunosuppressive Agents
/ therapeutic use
Killer Cells, Natural
/ drug effects
Male
Middle Aged
Peripheral Blood Stem Cells
/ drug effects
Retrospective Studies
Stem Cell Transplantation
/ adverse effects
T-Lymphocytes
/ drug effects
Transplantation Conditioning
/ adverse effects
Transplantation, Haploidentical
/ adverse effects
Transplantation, Homologous
/ adverse effects
Young Adult
Journal
Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R
Informations de publication
Date de publication:
01 09 2020
01 09 2020
Historique:
received:
19
05
2020
accepted:
04
07
2020
pubmed:
5
8
2020
medline:
23
3
2021
entrez:
5
8
2020
Statut:
ppublish
Résumé
A higher incidence of graft-versus-host disease (GVHD) has been observed after haploidentical hematopoietic stem cell transplantation (h-HSCT) with posttransplant cyclophosphamide (PTCY) using peripheral blood stem cells (PBSC) as a source of graft. Moreover, combining PTCY with antithymocyte globulin (ATG) may help to reduce GVHD incidence. In this study, early immune reconstitution, especially of T and NK cell compartments, was compared after both types of transplant (PTCY versus PTCY + ATG) investigate their influence on patient outcomes. This retrospective study included 58 adults who received a reduced intensity conditioning to PBSC h-HSCT with cyclosporine and mycophenolate mofetyl + PTCY (
Identifiants
pubmed: 32747504
pii: jimmunol.2000578
doi: 10.4049/jimmunol.2000578
doi:
Substances chimiques
Antilymphocyte Serum
0
CD3 Complex
0
Immunosuppressive Agents
0
Cyclophosphamide
8N3DW7272P
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1441-1448Informations de copyright
Copyright © 2020 by The American Association of Immunologists, Inc.