Modeling SHH-driven medulloblastoma with patient iPS cell-derived neural stem cells.
Anilides
/ pharmacology
Animals
Basal Cell Nevus Syndrome
/ genetics
Cell Line, Tumor
Cell Proliferation
/ drug effects
Galectin 1
/ genetics
Gene Expression Regulation, Neoplastic
/ drug effects
Hedgehog Proteins
/ genetics
Humans
Medulloblastoma
/ genetics
Mice
Neoplasms, Experimental
Neural Stem Cells
/ physiology
Patched-1 Receptor
/ genetics
Pyridines
/ pharmacology
disease model
medulloblastoma
neural stem cells
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
18 08 2020
18 08 2020
Historique:
pubmed:
5
8
2020
medline:
7
10
2020
entrez:
5
8
2020
Statut:
ppublish
Résumé
Medulloblastoma is the most common malignant brain tumor in children. Here we describe a medulloblastoma model using Induced pluripotent stem (iPS) cell-derived human neuroepithelial stem (NES) cells generated from a Gorlin syndrome patient carrying a germline mutation in the sonic hedgehog (SHH) receptor
Identifiants
pubmed: 32747535
pii: 1920521117
doi: 10.1073/pnas.1920521117
pmc: PMC7443968
doi:
Substances chimiques
Anilides
0
Galectin 1
0
Hedgehog Proteins
0
HhAntag691
0
PTCH1 protein, human
0
Patched-1 Receptor
0
Pyridines
0
SHH protein, human
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
20127-20138Subventions
Organisme : Wellcome Trust
ID : 201511/Z/16/Z
Pays : United Kingdom
Informations de copyright
Copyright © 2020 the Author(s). Published by PNAS.
Déclaration de conflit d'intérêts
The authors declare no competing interest.
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