A Zika virus envelope mutation preceding the 2015 epidemic enhances virulence and fitness for transmission.
Zika
envelope
evolution
transmission
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
18 08 2020
18 08 2020
Historique:
pubmed:
5
8
2020
medline:
7
10
2020
entrez:
5
8
2020
Statut:
ppublish
Résumé
Arboviruses maintain high mutation rates due to lack of proofreading ability of their viral polymerases, in some cases facilitating adaptive evolution and emergence. Here we show that, just before its 2013 spread to the Americas, Zika virus (ZIKV) underwent an envelope protein V473M substitution (E-V473M) that increased neurovirulence, maternal-to-fetal transmission, and viremia to facilitate urban transmission. A preepidemic Asian ZIKV strain (FSS13025 isolated in Cambodia in 2010) engineered with the V473M substitution significantly increased neurovirulence in neonatal mice and produced higher viral loads in the placenta and fetal heads in pregnant mice. Conversely, an epidemic ZIKV strain (PRVABC59 isolated in Puerto Rico in 2015) engineered with the inverse M473V substitution reversed the pathogenic phenotypes. Although E-V473M did not affect oral infection of
Identifiants
pubmed: 32747564
pii: 2005722117
doi: 10.1073/pnas.2005722117
pmc: PMC7443865
doi:
Substances chimiques
Viral Envelope Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
20190-20197Subventions
Organisme : NIAID NIH HHS
ID : R01 AI134907
Pays : United States
Organisme : NIAID NIH HHS
ID : R43 AI145617
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001439
Pays : United States
Organisme : ACL HHS
ID : U01CK000512
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI121452
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI142759
Pays : United States
Organisme : NIAID NIH HHS
ID : R24 AI120942
Pays : United States
Déclaration de conflit d'intérêts
The authors declare no competing interest.
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