Analysis of Ugandan cervical carcinomas identifies human papillomavirus clade-specific epigenome and transcriptome landscapes.

Adult Aged DNA Methylation / genetics Epigenome / genetics Female Humans Middle Aged Papillomaviridae / pathogenicity Papillomavirus Infections / genetics Promoter Regions, Genetic / genetics Signal Transduction / genetics Transcriptome / genetics Uganda Up-Regulation / genetics Uterine Cervical Neoplasms / genetics

Journal

Nature genetics
ISSN: 1546-1718
Titre abrégé: Nat Genet
Pays: United States
ID NLM: 9216904

Informations de publication

Date de publication:
08 2020
Historique:
received: 23 10 2019
accepted: 26 06 2020
entrez: 5 8 2020
pubmed: 5 8 2020
medline: 27 10 2020
Statut: ppublish

Résumé

Cervical cancer is the most common cancer affecting sub-Saharan African women and is prevalent among HIV-positive (HIV

Identifiants

DOI: 10.1038/s41588-020-0673-7 PMID: 32747824 PMC: PMC7498180
pubmed: 32747824
doi: 10.1038/s41588-020-0673-7
pii: 10.1038/s41588-020-0673-7
pmc: PMC7498180
mid: NIHMS1607577
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

800-810

Subventions

Organisme : NCI NIH HHS
ID : U01 CA096230
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA066535
Pays : United States
Organisme : NCI NIH HHS
ID : UM1 CA181255
Pays : United States
Organisme : NCI NIH HHS
ID : HHSN261201500003I
Pays : United States
Organisme : NIAID NIH HHS
ID : P30 AI027757
Pays : United States
Organisme : CCR NIH HHS
ID : HHSN261200800001C
Pays : United States
Organisme : NCI NIH HHS
ID : HHSN261200800001E
Pays : United States
Organisme : CIHR
ID : FDN-143288
Pays : Canada
Organisme : NCI NIH HHS
ID : P50 CA098258
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA217842
Pays : United States
Organisme : NCI NIH HHS
ID : HHSN261201500003C
Pays : United States
Organisme : CIHR
ID : GSD-164207
Pays : Canada
Organisme : CIHR
ID : GSD-152374
Pays : Canada

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Auteurs

Alessia Gagliardi (A)

Canada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, British Columbia, Canada.
ORCID: 0000-0002-6024-503X

Vanessa L Porter (VL)

Canada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, British Columbia, Canada.
Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.
ORCID: 0000-0002-7167-4884

Zusheng Zong (Z)

Canada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, British Columbia, Canada.

Reanne Bowlby (R)

Canada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, British Columbia, Canada.

Emma Titmuss (E)

Canada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, British Columbia, Canada.
ORCID: 0000-0002-1993-6912

Constance Namirembe (C)

Uganda Cancer Institute, Kampala, Uganda.
ORCID: 0000-0001-5979-8465

Nicholas B Griner (NB)

Office of Cancer Genomics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

Hilary Petrello (H)

Nationwide Children's Hospital, Columbus, OH, USA.

Jay Bowen (J)

Nationwide Children's Hospital, Columbus, OH, USA.
ORCID: 0000-0001-6861-9043

Simon K Chan (SK)

Canada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, British Columbia, Canada.

Luka Culibrk (L)

Canada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, British Columbia, Canada.

Teresa M Darragh (TM)

Department of Pathology, University of California at San Francisco, San Francisco, CA, USA.

Mark H Stoler (MH)

Department of Pathology, University of Virginia, Charlottesville, VA, USA.

Thomas C Wright (TC)

Department of Pathology and Cell Biology, Columbia University, New York, NY, USA.

Patee Gesuwan (P)

Office of Cancer Genomics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

Maureen A Dyer (MA)

Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
ORCID: 0000-0002-0681-3665

Yussanne Ma (Y)

Canada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, British Columbia, Canada.

Karen L Mungall (KL)

Canada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, British Columbia, Canada.

Steven J M Jones (SJM)

Canada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, British Columbia, Canada.
Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.
ORCID: 0000-0003-3394-2208

Carolyn Nakisige (C)

Uganda Cancer Institute, Kampala, Uganda.

Karen Novik (K)

Canada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, British Columbia, Canada.

Jackson Orem (J)

Uganda Cancer Institute, Kampala, Uganda.
ORCID: 0000-0002-5366-9010

Martin Origa (M)

Uganda Cancer Institute, Kampala, Uganda.

Julie M Gastier-Foster (JM)

Nationwide Children's Hospital, Columbus, OH, USA.
Departments of Pathology and Pediatrics, The Ohio State University, Columbus, OH, USA.

Robert Yarchoan (R)

Office of HIV and AIDS Malignancy, National Cancer Institute, National Institues of Health, Bethesda, MD, USA.
HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
ORCID: 0000-0002-3057-1395

Corey Casper (C)

Infectious Disease Research Institute, Seattle, WA, USA.
ORCID: 0000-0002-3609-661X

Gordon B Mills (GB)

Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.
ORCID: 0000-0002-0144-9614

Janet S Rader (JS)

Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI, USA.

Akinyemi I Ojesina (AI)

Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.
O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL, USA.
HudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.

Daniela S Gerhard (DS)

Office of Cancer Genomics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

Andrew J Mungall (AJ)

Canada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, British Columbia, Canada.
ORCID: 0000-0002-0905-2742

Marco A Marra (MA)

Canada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, British Columbia, Canada. mmarra@bcgsc.ca.
Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada. mmarra@bcgsc.ca.
ORCID: 0000-0001-7146-7175

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Analysis of Ugandan cervical carcinomas...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Analysis of Ugandan cervical carcinomas...
questionsmedicales.fr › Phénomènes génétiques › Méthylation de l'ADN › Analysis of Ugandan cervical carcinomas...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Épigénome › Analysis of Ugandan cervical carcinomas...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Analysis of Ugandan cervical carcinomas...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Analysis of Ugandan cervical carcinomas...
questionsmedicales.fr › Virus › Virus oncogènes › Virus tumoraux à ADN › Papillomaviridae › Analysis of Ugandan cervical carcinomas...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladies transmissibles › Maladies sexuellement transmissibles › Maladies sexuellement transmissibles virales › Infections à papillomavirus › Analysis of Ugandan cervical carcinomas...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Éléments de régulation transcriptionnelle › Régions promotrices (génétique) › Analysis of Ugandan cervical carcinomas...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Analysis of Ugandan cervical carcinomas...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Transcriptome › Analysis of Ugandan cervical carcinomas...
questionsmedicales.fr › Régions géographiques › Afrique › Afrique subsaharienne › Afrique de l'Est › Ouganda › Analysis of Ugandan cervical carcinomas...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Régulation positive › Analysis of Ugandan cervical carcinomas...
questionsmedicales.fr › Maladies urogénitales › Tumeurs de l'appareil urogénital › Tumeurs de l'appareil génital féminin › Tumeurs de l'utérus › Tumeurs du col de l'utérus › Analysis of Ugandan cervical carcinomas...