Tuning of olfactory cortex ventral tenia tecta neurons to distinct task elements of goal-directed behavior.
electrophysiology
mouse
neuroscience
olfactory cortex
tenia tecta
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
04 08 2020
04 08 2020
Historique:
received:
26
03
2020
accepted:
01
08
2020
pubmed:
5
8
2020
medline:
13
2
2021
entrez:
5
8
2020
Statut:
epublish
Résumé
The ventral tenia tecta (vTT) is a component of the olfactory cortex and receives both bottom-up odor signals and top-down signals. However, the roles of the vTT in odor-coding and integration of inputs are poorly understood. Here, we investigated the involvement of the vTT in these processes by recording the activity from individual vTT neurons during the performance of learned odor-guided reward-directed tasks in mice. We report that individual vTT cells are highly tuned to a specific behavioral epoch of learned tasks, whereby the duration of increased firing correlated with the temporal length of the behavioral epoch. The peak time for increased firing among recorded vTT cells encompassed almost the entire temporal window of the tasks. Collectively, our results indicate that vTT cells are selectively activated during a specific behavioral context and that the function of the vTT changes dynamically in a context-dependent manner during goal-directed behaviors.
Identifiants
pubmed: 32749216
doi: 10.7554/eLife.57268
pii: 57268
pmc: PMC7423337
doi:
pii:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Japan Society for the Promotion of Science
ID : Grant-in-Aid for JSPS Fellows 18J21358
Pays : International
Organisme : Japan Society for the Promotion of Science
ID : Grant-in-Aid for Challenging Exploratory Research 16K14557
Pays : International
Organisme : Japan Society for the Promotion of Science
ID : Grant-in-Aid for Scientific Research on Innovative Areas 25135708
Pays : International
Organisme : Japan Society for the Promotion of Science
ID : Grant-in-Aid for Scientific Research(A) 16H02061
Pays : International
Organisme : Japan Society for the Promotion of Science
ID : Grant-in-Aid for Scientific Research on Innovative Areas 18H05088
Pays : International
Organisme : Japan Society for the Promotion of Science
ID : Grant-in-Aid for JSPS Fellows 19J20733
Pays : International
Informations de copyright
© 2020, Shiotani et al.
Déclaration de conflit d'intérêts
KS, YT, KM, JH, YS, HM No competing interests declared
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