Retinal vessel architecture in retinopathy of prematurity and healthy controls using swept-source optical coherence tomography angiography.
Child
Child, Preschool
Cross-Sectional Studies
Female
Fluorescein Angiography
/ methods
Fundus Oculi
Gestational Age
Humans
Infant
Infant, Newborn
Macula Lutea
/ blood supply
Male
Retinal Vessels
/ pathology
Retinopathy of Prematurity
/ diagnosis
Retrospective Studies
Tomography, Optical Coherence
/ methods
Visual Acuity
choroidal vascular flow area
foveal avascular zone
retinopathy of prematurity
swept-source optical coherence tomography angiography
vessel density
Journal
Acta ophthalmologica
ISSN: 1755-3768
Titre abrégé: Acta Ophthalmol
Pays: England
ID NLM: 101468102
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
07
01
2020
accepted:
02
07
2020
pubmed:
5
8
2020
medline:
23
9
2021
entrez:
5
8
2020
Statut:
ppublish
Résumé
To determine microvascular changes in children with a history of retinopathy of prematurity (ROP) and in a control group of full-term children. In a cross-sectional study, 30 eyes of 15 children aged 6-8 years with a history of ROP were evaluated with swept-source optical coherence tomography angiography (SS-OCTA). Twenty-eight eyes of 22 age-matched full-term children served as a healthy control group. The foveal avascular zone (FAZ), vessel density (VD) and choroidal vascular flow area (VFA) were evaluated on OCTA and correlated with central retinal thickness (CRT), visual acuity (VA), birth weight (BW), gestational age (GA) and ROP stages. Twenty-two eyes of 14 children with a history of ROP (stage 1-3) and 25 eyes of 19 full-term children were available for evaluation. In the ROP group, the gestational age was 27 ± 2 weeks and birth weight was 781 ± 164 g. In the ROP group, CRT was higher in the central ETDRS segment (mean difference [95% CI]: 32.8 µm [18.7; 47.0], p = 0.0002) compared to the controls. Smaller mean FAZ area (-0.12 [-0.19; -0.04], p = 0.004) and perimeter (-662 [-1228; -96], p = 0.03) was found in comparison to the control group. An oval shape of the FAZ was observed among patients with a history of ROP. The mean central VD of the superficial plexus was 28 ± 8/23 ± 8% and of the deep plexus 7 ± 7/3 ± 5% (ROP group/control group; p > 0.05). No statistically significant difference was found regarding the choroidal VFA. Only weak correlation of FAZ and VD with function was observed. Swept-source optical coherence tomography angiography imaging revealed significant microvascular anomalies in children with a history of ROP indicating disturbance of early morphological development of the central retina.
Identifiants
pubmed: 32749763
doi: 10.1111/aos.14557
pmc: PMC7984179
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e232-e239Informations de copyright
© 2020 The Authors. Acta Ophthalmologica published by John Wiley & Sons Ltd on behalf of Acta Ophthalmologica Scandinavica Foundation.
Références
Eye (Lond). 2019 Dec;33(12):1890-1896
pubmed: 31273311
Pediatr Res. 1996 Mar;39(3):487-93
pubmed: 8929870
Pediatrics. 2002 Jan;109(1):12-8
pubmed: 11773536
Eye (Lond). 2018 Jan;32(1):104-112
pubmed: 28776594
Retina. 2020 Jul;40(7):1279-1285
pubmed: 31274711
Am J Ophthalmol. 2016 Apr;164:80-8
pubmed: 26851725
Arch Ophthalmol. 2008 Apr;126(4):507-11
pubmed: 18413520
Invest Ophthalmol Vis Sci. 2000 Apr;41(5):1217-28
pubmed: 10752963
Opt Express. 2012 Feb 13;20(4):4710-25
pubmed: 22418228
Retina. 2019 Jan;39(1):111-117
pubmed: 29190231
Eye (Lond). 2018 Jun;32(6):1062-1066
pubmed: 29398701
Nat Methods. 2012 Jun 28;9(7):676-82
pubmed: 22743772
Invest Ophthalmol Vis Sci. 2012 Oct 17;53(11):7201-7
pubmed: 23033393
Invest Ophthalmol Vis Sci. 2017 Apr 1;58(4):2002-2010
pubmed: 28384721
Prog Retin Eye Res. 2018 Jan;62:58-76
pubmed: 29081352
Retina. 2016 Jun;36(6):1191-8
pubmed: 26583308
Invest Ophthalmol Vis Sci. 2017 Oct 1;58(12):4948-4958
pubmed: 28973368
J Ophthalmol. 2019 Jul 2;2019:8340729
pubmed: 31341658
World J Clin Pediatr. 2016 Feb 08;5(1):35-46
pubmed: 26862500
Prog Retin Eye Res. 2018 Mar;63:1-19
pubmed: 29129724
Curr Opin Ophthalmol. 2010 Sep;21(5):329-34
pubmed: 20634698
JAMA Ophthalmol. 2013 Nov;131(11):1451-8
pubmed: 24077425
Invest Ophthalmol Vis Sci. 2014 Nov 06;55(12):8278-88
pubmed: 25377222
Ophthalmology. 1984 Jun;91(6):603-12
pubmed: 6462623
Sci Rep. 2016 Dec 05;6:38132
pubmed: 27917889
Graefes Arch Clin Exp Ophthalmol. 2019 Jan;257(1):23-30
pubmed: 30361765
Retina. 2017 Dec;37(12):2289-2294
pubmed: 28098735
Br J Ophthalmol. 2012 Jul;96(7):961-6
pubmed: 22544530
Ophthalmol Retina. 2018 Sep;2(9):972-978
pubmed: 31047230
Am J Ophthalmol. 2014 Sep;158(3):508-12.e2
pubmed: 24874998
Retina. 2015 Nov;35(11):2163-80
pubmed: 26428607