Non-Melanoma Skin Cancers: Biological and Clinical Features.
Antibodies, Monoclonal
/ therapeutic use
Antigens, Neoplasm
/ genetics
Antineoplastic Agents, Immunological
/ therapeutic use
Carcinogenesis
/ genetics
Carcinoma, Basal Cell
/ drug therapy
Carcinoma, Merkel Cell
/ drug therapy
Carcinoma, Squamous Cell
/ drug therapy
Clinical Trials as Topic
Gene Expression Regulation, Neoplastic
Hedgehog Proteins
/ antagonists & inhibitors
Humans
Immunotherapy
/ methods
Programmed Cell Death 1 Receptor
/ antagonists & inhibitors
Signal Transduction
Skin Neoplasms
/ drug therapy
Hedgehog pathway
Merkel cell carcinoma
anti-PD1 monoclonal antibodies
basal cell carcinoma
immunotherapy
skin cancer
squamous cell carcinoma
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
29 Jul 2020
29 Jul 2020
Historique:
received:
08
07
2020
revised:
24
07
2020
accepted:
27
07
2020
entrez:
6
8
2020
pubmed:
6
8
2020
medline:
20
2
2021
Statut:
epublish
Résumé
Non-melanoma skin cancers (NMSCs) include basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and Merkel cell carcinoma (MCC). These neoplasms are highly diverse in their clinical presentation, as well as in their biological evolution. While the deregulation of the Hedgehog pathway is commonly observed in BCC, SCC and MCC are characterized by a strikingly elevated mutational and neoantigen burden. As result of our improved understanding of the biology of non-melanoma skin cancers, innovative treatment options including inhibitors of the Hedgehog pathway and immunotherapeutic agents have been recently investigated against these malignancies, leading to their approval by regulatory authorities. Herein, we review the most relevant biological and clinical features of NMSC, focusing on innovative treatment approaches.
Identifiants
pubmed: 32751327
pii: ijms21155394
doi: 10.3390/ijms21155394
pmc: PMC7432795
pii:
doi:
Substances chimiques
Antibodies, Monoclonal
0
Antigens, Neoplasm
0
Antineoplastic Agents, Immunological
0
Hedgehog Proteins
0
PDCD1 protein, human
0
Programmed Cell Death 1 Receptor
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Regione Puglia
ID : Precision Medicine Project
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