Iron deficiency and supplementation in heart failure and chronic kidney disease.
Chronic kidney disease
Heart failure
Intravenous iron
Iron deficiency
Journal
Molecular aspects of medicine
ISSN: 1872-9452
Titre abrégé: Mol Aspects Med
Pays: England
ID NLM: 7603128
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
28
02
2020
revised:
26
05
2020
accepted:
02
07
2020
pubmed:
6
8
2020
medline:
25
9
2021
entrez:
6
8
2020
Statut:
ppublish
Résumé
Iron is a key element for normal cellular function and plays a role in many cellular processes including mitochondrial respiration. The role of iron deficiency (ID) in heart failure (HF) has been a subject of debate amid increasing advocacy for intravenous (IV) supplementation. Both the definition and the approach to treatment of ID in HF have been adapted from the experience in patients with chronic kidney disease (CKD). In this review, we highlight the differences in regulatory mechanisms as well as pathophysiology of ID in CKD and HF population both at the systemic and cellular levels. We will review the major clinical trials in HF patients that have shown symptomatic benefit from IV iron supplementation but without effect on clinical outcomes. Intravenous iron loading bypasses the mechanisms that tightly regulate iron uptake and can potentially cause myocardial and endothelial damage by releasing reactive oxygen species. By contrast, newer oral iron preparations do not have similar toxicity concerns and might have a role in heart failure.
Identifiants
pubmed: 32753256
pii: S0098-2997(20)30026-1
doi: 10.1016/j.mam.2020.100873
pmc: PMC7554149
mid: NIHMS1618829
pii:
doi:
Substances chimiques
Iron
E1UOL152H7
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
100873Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL127646
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL138982
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL140927
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL140973
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
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