Conditional inactivation of Npy1r gene in mice induces sex-related differences of metabolic and behavioral functions.
Animals
Anxiety
/ genetics
Arcuate Nucleus of Hypothalamus
/ metabolism
Behavior, Animal
/ physiology
Energy Metabolism
/ genetics
Female
Gene Silencing
/ physiology
Hypothalamo-Hypophyseal System
/ metabolism
Hypothalamus
/ metabolism
Leptin
/ metabolism
Limbic System
/ metabolism
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Paraventricular Hypothalamic Nucleus
/ metabolism
Pituitary-Adrenal System
/ metabolism
Receptors, Neuropeptide Y
/ genetics
Sex Characteristics
Anxious behavior
Body weight
Conditional knockout mice
Executive behavior
Hypothalamic neuropeptides
Hypothalamus-pituitary-adrenal axis activity
Neuropeptide Y
Sexual dimorphism
Y1 receptor
Journal
Hormones and behavior
ISSN: 1095-6867
Titre abrégé: Horm Behav
Pays: United States
ID NLM: 0217764
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
10
02
2020
revised:
15
07
2020
accepted:
23
07
2020
pubmed:
7
8
2020
medline:
21
4
2021
entrez:
7
8
2020
Statut:
ppublish
Résumé
Sex hormone-driven differences in gene expression have been identified in experimental animals, highlighting brain neuronal populations implicated in dimorphism of metabolic and behavioral functions. Neuropeptide Y-Y1 receptor (NPY-Y1R) system is sexually dimorphic and sensitive to gonadal steroids. In the present study we compared the phenotype of male and female conditional knockout mice (Npy1r
Identifiants
pubmed: 32755609
pii: S0018-506X(20)30150-1
doi: 10.1016/j.yhbeh.2020.104824
pii:
doi:
Substances chimiques
Leptin
0
Receptors, Neuropeptide Y
0
neuropeptide Y-Y1 receptor
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
104824Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.