Synthesis and biological evaluation of ethacrynic acid derivatives bearing sulfonamides as potent anti-cancer agents.
Anti-cancer
Anti-proliferative
Cancer cells
Ethacrynic acid
Safety ratios
Sulfonamides
Journal
Bioorganic & medicinal chemistry letters
ISSN: 1464-3405
Titre abrégé: Bioorg Med Chem Lett
Pays: England
ID NLM: 9107377
Informations de publication
Date de publication:
01 10 2020
01 10 2020
Historique:
received:
01
06
2020
revised:
16
07
2020
accepted:
18
07
2020
pubmed:
7
8
2020
medline:
22
6
2021
entrez:
7
8
2020
Statut:
ppublish
Résumé
A series of ethacrynic acid (2-[2,3-dichloro-4-(2-methylidenebutanoyl)phenoxy]acetic acid) (EA, Edecrin) containing sulfonamides linked via three types of linkers namely 1,2-ethylenediamine, piperazine and 4-aminopiperidine was synthesized and subsequently evaluated in vitro against HL60 and HCT116 cancer cell lines. All the EA analogs, excluding 6a and 6c, showed anti-proliferative activity with IC
Identifiants
pubmed: 32755677
pii: S0960-894X(20)30537-0
doi: 10.1016/j.bmcl.2020.127426
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Sulfonamides
0
Ethacrynic Acid
M5DP350VZV
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
127426Informations de copyright
Copyright © 2020. Published by Elsevier Ltd.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.