Role of carboxylic group pattern on protein surface in the recognition of iron oxide nanoparticles: A key for protein corona formation.
Iron oxide nanoparticles
Nanomaterial surface
Nanoparticle recognition
Protein binding
Protein corona
Journal
International journal of biological macromolecules
ISSN: 1879-0003
Titre abrégé: Int J Biol Macromol
Pays: Netherlands
ID NLM: 7909578
Informations de publication
Date de publication:
01 Dec 2020
01 Dec 2020
Historique:
received:
21
05
2020
revised:
26
07
2020
accepted:
27
07
2020
pubmed:
8
8
2020
medline:
10
4
2021
entrez:
8
8
2020
Statut:
ppublish
Résumé
The knowledge of protein-nanoparticle interplay is of crucial importance to predict the fate of nanomaterials in biological environments. Indeed, protein corona on nanomaterials is responsible for the physiological response of the organism, influencing cell processes, from transport to accumulation and toxicity. Herein, a comparison using four different proteins reveals the existence of patterned regions of carboxylic groups acting as recognition sites for naked iron oxide nanoparticles. Readily interacting proteins display a distinctive surface distribution of carboxylic groups, recalling the geometric shape of an ellipse. This is morphologically complementary to nanoparticles curvature and compatible with the topography of exposed Fe
Identifiants
pubmed: 32758605
pii: S0141-8130(20)34054-X
doi: 10.1016/j.ijbiomac.2020.07.295
pii:
doi:
Substances chimiques
Ferric Compounds
0
Membrane Proteins
0
Protein Corona
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1715-1728Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.