Regulation of organic anion transporters: Role in physiology, pathophysiology, and drug elimination.
ATP-Binding Cassette Transporters
/ metabolism
Acute Kidney Injury
/ metabolism
Animals
Biological Transport
Drug Elimination Routes
Drug Interactions
/ physiology
Glycosylation
Humans
Kidney
/ metabolism
Kidney Diseases
/ metabolism
Multidrug Resistance-Associated Proteins
/ metabolism
Organic Anion Transporters
/ genetics
Organic Cation Transport Proteins
/ metabolism
Phosphorylation
/ physiology
Polymorphism, Genetic
Proteasome Endopeptidase Complex
/ metabolism
Ubiquitin
/ metabolism
Drug disposition
Drug transporter
Organic anion transporter
Post-translational modification
Regulation
Journal
Pharmacology & therapeutics
ISSN: 1879-016X
Titre abrégé: Pharmacol Ther
Pays: England
ID NLM: 7905840
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
02
06
2020
accepted:
27
07
2020
pubmed:
8
8
2020
medline:
16
11
2021
entrez:
8
8
2020
Statut:
ppublish
Résumé
The members of the organic anion transporter (OAT) family are mainly expressed in kidney, liver, placenta, intestine, and brain. These transporters play important roles in the disposition of clinical drugs, pesticides, signaling molecules, heavy metal conjugates, components of phytomedicines, and toxins, and therefore critical for maintaining systemic homeostasis. Alterations in the expression and function of OATs contribute to the intra- and inter-individual variability of the therapeutic efficacy and the toxicity of many drugs, and to many pathophysiological conditions. Consequently, the activity of these transporters must be highly regulated to carry out their normal functions. This review will present an update on the recent advance in understanding the cellular and molecular mechanisms underlying the regulation of renal OATs, emphasizing on the post-translational modification (PTM), the crosstalk among these PTMs, and the remote sensing and signaling network of OATs. Such knowledge will provide significant insights into the roles of these transporters in health and disease.
Identifiants
pubmed: 32758646
pii: S0163-7258(20)30177-7
doi: 10.1016/j.pharmthera.2020.107647
pmc: PMC7770002
mid: NIHMS1617424
pii:
doi:
Substances chimiques
ATP-Binding Cassette Transporters
0
Multidrug Resistance-Associated Proteins
0
Organic Anion Transporters
0
Organic Cation Transport Proteins
0
Ubiquitin
0
urate transporter
0
Proteasome Endopeptidase Complex
EC 3.4.25.1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
107647Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM079123
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM097000
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM127788
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that there are no conflicts of interest.
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