Inhaled bronchodilator exposure in the management of bronchopulmonary dysplasia in hospitalized infants.
Journal
Journal of perinatology : official journal of the California Perinatal Association
ISSN: 1476-5543
Titre abrégé: J Perinatol
Pays: United States
ID NLM: 8501884
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
05
02
2020
accepted:
22
07
2020
revised:
02
07
2020
pubmed:
8
8
2020
medline:
1
9
2021
entrez:
8
8
2020
Statut:
ppublish
Résumé
To determine clinical, demographic, and hospital factors associated with inhaled bronchodilator (IB) use in infants with bronchopulmonary dysplasia (BPD) and specifically severe BPD. Retrospective multicenter cohort study of 4986 infants born <32 weeks gestation with developing BPD at 28 days of life. We used the Pediatric Health Information System database to compare hospital experience and the demographic and clinical characteristics of infants exposed and not exposed to IBs. Twenty-five percent of BPD patients (1224/4986) and 48% of severe BPD patients (664/1390) received IBs. IB exposure was higher in infants with the tracheostomy, prolonged steroid and diuretic exposure, and longer duration of respiratory support. IB use varied markedly between hospitals (0-59%). Average annual BPD census was not associated with IB use. Bronchodilator exposure is common in BPD patients with substantial variability in its use. Hospital experience did not account for the between-hospital variation in practice.
Identifiants
pubmed: 32759956
doi: 10.1038/s41372-020-0760-8
pii: 10.1038/s41372-020-0760-8
pmc: PMC7404081
doi:
Substances chimiques
Bronchodilator Agents
0
Types de publication
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
53-61Subventions
Organisme : NIH HHS
ID : UG1 OD024953
Pays : United States
Références
Chest. 2001 Oct;120(4):1184-9
pubmed: 11591558
J Perinatol. 2015 Jan;35(1):61-6
pubmed: 25102319
Respir Med. 2005 May;99(5):566-71
pubmed: 15823453
J Pediatr. 2019 May;208:148-155.e3
pubmed: 30857774
Thorax. 2001 Jul;56(7):529-35
pubmed: 11413351
Res Rep Neonatol. 2015;5:113-117
pubmed: 27812297
J Pediatr. 1987 Aug;111(2):278-82
pubmed: 2956405
PLoS One. 2019 Sep 11;14(9):e0222286
pubmed: 31509594
Am J Perinatol. 2015 Aug;32(10):960-7
pubmed: 25738785
Arch Dis Child Fetal Neonatal Ed. 1997 May;76(3):F203-5
pubmed: 9175954
Eur J Pediatr. 1998 Nov;157(11):926-31
pubmed: 9835439
Pediatr Pulmonol. 2020 Feb;55(2):360-368
pubmed: 31794157
J Perinatol. 2018 Sep;38(9):1258-1265
pubmed: 29880793
J Matern Fetal Neonatal Med. 2019 Mar 28;:1-3
pubmed: 30922128
J Pediatr. 2018 Jun;197:300-308
pubmed: 29551318
J Allergy Clin Immunol. 2007 Nov;120(5 Suppl):S94-138
pubmed: 17983880
Am J Respir Crit Care Med. 2019 Sep 15;200(6):751-759
pubmed: 30995069
Acta Paediatr. 2017 May;106(5):692-693
pubmed: 28383198
Pediatrics. 2010 Sep;126(3):443-56
pubmed: 20732945
Arch Pediatr Adolesc Med. 2007 Nov;161(11):1082-7
pubmed: 17984411
J Pediatr. 2018 Jun;197:8-10
pubmed: 29605396
Semin Perinatol. 2013 Apr;37(2):132-7
pubmed: 23582968
Am J Perinatol. 2014 Oct;31(9):811-21
pubmed: 24347262
J Pediatr. 1989 Dec;115(6):984-91
pubmed: 2685221
J Perinatol. 2019 Sep;39(9):1291-1299
pubmed: 31227785
Birth Defects Res A Clin Mol Teratol. 2014 Mar;100(3):145-57
pubmed: 24639412
Cochrane Database Syst Rev. 2016 Dec 14;12:CD003214
pubmed: 27960245
J Pediatr. 2005 Jun;146(6):798-804
pubmed: 15973322
Pediatr Pulmonol. 1986 Sep-Oct;2(5):269-73
pubmed: 3774383