Dermal and inhalable cobalt exposure-Uptake of cobalt for workers at Swedish hard metal plants.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2020
2020
Historique:
received:
13
03
2020
accepted:
20
07
2020
entrez:
8
8
2020
pubmed:
8
8
2020
medline:
7
10
2020
Statut:
epublish
Résumé
Cobalt exposure is known to cause adverse effects on health. A major use of cobalt is in the manufacture of hard metal. Exposure can lead to asthma, hard metal lung disease, contact allergy and increased risk of cancer. Cobalt is mainly absorbed from the pulmonary tract, however penetration through skin may occur. The relationships between exposure to inhalable cobalt in air and on skin and the uptake in blood and urine will be investigated, as well as the association between dermal symptoms and dermal exposure. Cobalt exposure in 71 workers in hard metal production facilities was measured as inhalable cobalt in the breathing zone and cobalt found on skin with acid wash. Uptake of cobalt was determined with concentrations in blood and urine. Correlations between exposure and uptake were analysed. Inhalable cobalt in air and cobalt in blood and urine showed rank correlations with coefficients 0.40 and 0.25. Cobalt on skin and uptake in blood and urine presented correlation coefficients of 0.36 and 0.17. Multiple linear regression of cobalt in air and on skin with cobalt in blood showed regression coefficients with cobalt in blood (β = 203 p < 0.0010, and β = 0.010, p = 0.0040) and with cobalt in urine (β = 5779, p = 0.0010, and β = 0.10, p = 0.60). Our data presents statistically significant correlations between exposure to cobalt in air with uptake of cobalt in blood and urine. Cobalt on skin was statistically significant with cobalt in blood but not with urine.
Identifiants
pubmed: 32760159
doi: 10.1371/journal.pone.0237100
pii: PONE-D-20-07315
pmc: PMC7410254
doi:
Substances chimiques
Air Pollutants, Occupational
0
Cobalt
3G0H8C9362
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0237100Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Ind Health. 1989;27(4):155-63
pubmed: 2613559
Med Sci (Paris). 2016 8-9;32(8-9):732-8
pubmed: 27615181
Int Arch Occup Environ Health. 1997;69(3):193-200
pubmed: 9049670
Sci Total Environ. 1994 Jun 30;150(1-3):141-4
pubmed: 7939587
Sci Total Environ. 1994 Jun 30;150(1-3):201-7
pubmed: 7939597
Acta Orthop. 2006 Oct;77(5):697-705
pubmed: 17068698
Occup Med. 1987 Apr-Jun;2(2):327-44
pubmed: 3303384
Sci Total Environ. 1994 Jun 30;150(1-3):1-6
pubmed: 7939580
Int J Environ Res Public Health. 2016 Sep 21;13(9):
pubmed: 27657104
J Occup Environ Med. 2012 Apr;54(4):409-13
pubmed: 22446572
Contact Dermatitis. 2006 May;54(5):233-8
pubmed: 16689805
Int Arch Occup Environ Health. 1985;55(4):269-76
pubmed: 4008051
Arch Intern Med. 1990 Jan;150(1):177-83
pubmed: 2297286
Int Arch Occup Environ Health. 2019 Nov;92(8):1087-1098
pubmed: 31165309
Contact Dermatitis. 2009 Mar;60(3):165-70
pubmed: 19260915
Toxicology. 2017 Jul 15;387:43-56
pubmed: 28572025
Hip Int. 2019 Nov;29(6):638-646
pubmed: 30479165
IARC Monogr Eval Carcinog Risks Hum. 1991;52:1-544
pubmed: 1683674
Br J Ind Med. 1993 Sep;50(9):835-42
pubmed: 8398878
Ann Occup Hyg. 2016 Jul;60(6):684-99
pubmed: 27143598
IARC Monogr Eval Carcinog Risks Hum. 2006;86:1-294
pubmed: 16906675
Int Arch Occup Environ Health. 1985;57(1):19-26
pubmed: 4077278
Contact Dermatitis. 2010 Aug;63(2):70-6
pubmed: 20629672
Contact Dermatitis. 2017 Oct;77(4):201-207
pubmed: 28675438
J Orthop Res. 1989;7(3):307-15
pubmed: 2649648
Can Med Assoc J. 1967 Oct 7;97(15):926-8
pubmed: 6051264
Am J Ind Med. 2003 Aug;44(2):124-32
pubmed: 12874844
Contact Dermatitis. 2014 Jun;70(6):361-8
pubmed: 24617983
Am J Epidemiol. 1998 Aug 1;148(3):241-8
pubmed: 9690360
Br J Ind Med. 1986 Jul;43(7):486-9
pubmed: 3718896
Sci Total Environ. 2012 Aug 15;432:210-5
pubmed: 22732165
Regul Toxicol Pharmacol. 2014 Apr;68(3):447-67
pubmed: 24530804
J Toxicol Clin Toxicol. 1999;37(2):201-6
pubmed: 10382556
Ann Occup Hyg. 2010 Apr;54(3):340-50
pubmed: 20150401
J Am Acad Dermatol. 1986 Jul;15(1):1-10
pubmed: 2941461
Am J Ind Med. 1994 Nov;26(5):585-95
pubmed: 7832207
Chest. 1989 Jan;95(1):29-37
pubmed: 2909353
J Appl Toxicol. 2015 Jun;35(6):551-72
pubmed: 25809475
Int Arch Occup Environ Health. 1993;65(4):233-40
pubmed: 8144233