Alox12/15 Deficiency Exacerbates, While Lipoxin A
Animals
Arachidonate 12-Lipoxygenase
/ genetics
Arachidonate 15-Lipoxygenase
/ genetics
Disease Models, Animal
Hepatitis, Alcoholic
/ genetics
Humans
Inflammation
/ genetics
Lipid Metabolism
Lipoxins
/ metabolism
Liver
/ physiology
Mice
Mice, Inbred C57BL
Mice, Knockout
Neutrophil Activation
/ genetics
Neutrophils
/ immunology
alcoholic hepatitis
arachidonate 12/15-lipoxygenase (Alox12/15)
lipoxin A4
resolution of inflammation
specialized pro-resolving lipid mediators (SPMs)
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
02
04
2020
accepted:
04
06
2020
entrez:
8
8
2020
pubmed:
8
8
2020
medline:
17
4
2021
Statut:
epublish
Résumé
Alcoholism is one of the leading and increasingly prevalent reasons of liver associated morbidity and mortality worldwide. Alcoholic hepatitis (AH) constitutes a severe disease with currently no satisfying treatment options. Lipoxin A
Identifiants
pubmed: 32760397
doi: 10.3389/fimmu.2020.01447
pmc: PMC7371948
doi:
Substances chimiques
Lipoxins
0
lipoxin A4
0
Arachidonate 12-Lipoxygenase
EC 1.13.11.31
ALOX12 protein, human
EC 1.13.11.31.
ALOX15 protein, human
EC 1.13.11.33
Arachidonate 15-Lipoxygenase
EC 1.13.11.33
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1447Informations de copyright
Copyright © 2020 Queck, Fink, Sirait-Fischer, Rüschenbaum, Thomas, Snodgrass, Geisslinger, Baba, Trebicka, Zeuzem, Weigert, Lange and Brüne.
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