Gerd Geisslinger

Affiliations
  • Branch for Translational Medicine and Pharmacology, Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Frankfurt am Main, Germany.
  • Faculty of Medicine, Institute of Clinical Pharmacology, Pharmazentrum Frankfurt, ZAFES, Frankfurt am Main, Germany.

Publications (94)

Zafirlukast Is a Dual Modulator of Human Soluble Epoxide Hydrolase and Peroxisome Proliferator-Activated Receptor γ.

Frontiers in pharmacology
Avec: Tamara Göbel , Olaf Diehl , Jan Heering , Daniel Merk , Carlo Angioni , Sandra K Wittmann , Estel la Buscato , Ramona Kottke , Lilia Weizel , Tim Schader , Thorsten J Maier , Gerd Geisslinger , Manfred Schubert-Zsilavecz , Dieter Steinhilber , Ewgenij Proschak , Astrid S Kahnt

5-Amino-1-β-D-Ribofuranosyl-Imidazole-4-Carboxamide (AICAR) Reduces Peripheral Inflammation by Macrophage Phenotype Shift.

International journal of molecular sciences
Avec: Lisa Maria Martin , Moritz Möller , Ulrike Weiss , Otto Quintus Russe , Klaus Scholich , Sandra Pierre , Gerd Geisslinger , Ellen Niederberger

A Data Science-Based Analysis Points at Distinct Patterns of Lipid Mediator Plasma Concentrations in Patients With Dementia.

Frontiers in psychiatry
Avec: Robert Gurke , Semra Etyemez , David Prvulovic , Dominique Thomas , Stefanie C Fleck , Andreas Reif , Gerd Geisslinger , Jörn Lötsch

Inhibition of the protein kinase IKKepsilon attenuates neuropathic pain in mice.

Neuropharmacology
Avec: Christine V Möser , Moritz Möller , Stefanie C Fleck , Dominique Thomas , Gerd Geisslinger , Ellen Niederberger

Predictive PBPK modeling as a tool in the formulation of the drug candidate TMP-001.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
Avec: Lisa Nothnagel , Fabian Jung , Tanja Rossmanith , Manuela Thurn , Mukul Ashtikar , Gerd Geisslinger , Michael J Parnham , Matthias G Wacker

CXCL16/CXCR6-mediated adhesion of human peripheral blood mononuclear cells to inflamed endothelium.

Cytokine
Avec: Bona Linke , Sascha Meyer Dos Santos , Bettina Picard-Willems , Michael Keese , Sebastian Harder , Gerd Geisslinger , Klaus Scholich

Influence of glycosphingolipids on cancer cell energy metabolism.

Progress in lipid research
Avec: Nina Schömel , Gerd Geisslinger , Marthe-Susanna Wegner

Machine-Learned Association of Next-Generation Sequencing-Derived Variants in Thermosensitive Ion Channels Genes with Human Thermal Pain Sensitivity Phenotypes.

International journal of molecular sciences
Avec: Jörn Lötsch , Dario Kringel , Gerd Geisslinger , Bruno G Oertel , Eduard Resch , Sebastian Malkusch

Trehalose Reduces Nerve Injury Induced Nociception in Mice but Negatively Affects Alertness.

Nutrients
Avec: Vanessa Kraft , Katja Schmitz , Annett Wilken-Schmitz , Gerd Geisslinger , Marco Sisignano , Irmgard Tegeder

Lipidomic analysis of local inflammation models shows a specific systemic acute phase response to lipopolysaccharides.

Biochimica et biophysica acta. Molecular and cell biology of lipids
Avec: Lisa Hahnefeld , Lisa Kornstädt , Daniel Kratz , Nerea Ferreirós , Gerd Geisslinger , Sandra Pierre , Klaus Scholich

GPR40 Activation Abolishes Diabetes-Induced Painful Neuropathy by Suppressing VEGF-A Expression.

Diabetes
Avec: Vanessa Königs , Sandra Pierre , Martin Schicht , Jessica Welss , Lisa Hahnefeld , Vittoria Rimola , Elke Lütjen-Drecoll , Gerd Geisslinger , Klaus Scholich

Inhibitors of Human 5-Lipoxygenase Potently Interfere With Prostaglandin Transport.

Frontiers in pharmacology
Avec: Astrid S Kahnt , Carlo Angioni , Tamara Göbel , Bettina Hofmann , Jessica Roos , Svenja D Steinbrink , Florian Rörsch , Dominique Thomas , Gerd Geisslinger , Kai Zacharowski , Sabine Grösch , Dieter Steinhilber , Thorsten J Maier

Oxidized linoleic acid metabolites maintain mechanical and thermal hypersensitivity during sub-chronic inflammatory pain.

Biochemical pharmacology
Avec: Saskia Wedel , Tabea Osthues , Béla Zimmer , Carlo Angioni , Gerd Geisslinger , Marco Sisignano

SAFit2 ameliorates paclitaxel-induced neuropathic pain by reducing spinal gliosis and elevating pro-resolving lipid mediators.

Journal of neuroinflammation
Avec: Saskia Wedel , Lisa Hahnefeld , Yannick Schreiber , Christian Namendorf , Tim Heymann , Manfred Uhr , Mathias V Schmidt , Natasja de Bruin , Felix Hausch , Dominique Thomas , Gerd Geisslinger , Marco Sisignano

Repetitive and compulsive behavior after Early-Life-Pain associated with reduced long-chain sphingolipid species.

Cell & bioscience
Avec: Alexandra Vogel , Timo Ueberbach , Annett Wilken-Schmitz , Lisa Hahnefeld , Luisa Franck , Marc-Philipp Weyer , Tassilo Jungenitz , Tobias Schmid , Giulia Buchmann , Florian Freudenberg , Ralf P Brandes , Robert Gurke , Stephan W Schwarzacher , Gerd Geisslinger , Thomas Mittmann , Irmgard Tegeder

Short-term predictor for COVID-19 severity from a longitudinal multi-omics study for practical application in intensive care units.

Talanta
Avec: Sabine Kugler , Lisa Hahnefeld , Jan Andreas Kloka , Sebastian Ginzel , Elina Nürenberg-Goloub , Sebastian Zinn , Maria Jgt Vehreschild , Kai Zacharowski , Simone Lindau , Evelyn Ullrich , Jan Burmeister , Jörn Kohlhammer , Joachim Schwäble , Robert Gurke , Erika Dorochow , Alexandre Bennett , Stephanie Dauth , Julia Campe , Tilo Knape , Volker Laux , Aimo Kannt , Michaela Köhm , Gerd Geisslinger , Eduard Resch , Frank Behrens

Distinct molecular mechanisms contribute to the reduction of melanoma growth and tumor pain after systemic and local depletion of alpha-Synuclein in mice.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Avec: Ellen Niederberger , Moritz Möller , Eleonora Mungo , Michelle Hass , Annett Wilken-Schmitz , Christine Manderscheid , Christine V Möser , Gerd Geisslinger

Endocannabinoid analysis in GlucoEXACT plasma: Method validation and sample handling recommendations.

Talanta
Avec: A Sens , D Thomas , S M G Schäfer , A König , A Pinter , I Tegeder , G Geisslinger , R Gurke

Oleic acid released by sensory neurons inhibits TRPV1-mediated thermal hypersensitivity via GPR40.

iScience
Avec: Maksim Sendetski , Saskia Wedel , Kenta Furutani , Lisa Hahnefeld , Carlo Angioni , Jan Heering , Béla Zimmer , Sandra Pierre , Alexandra-Maria Banica , Klaus Scholich , Sorin Tunaru , Gerd Geisslinger , Ru-Rong Ji , Marco Sisignano

Machine learning and biological validation identify sphingolipids as potential mediators of paclitaxel-induced neuropathy in cancer patients.

eLife
Avec: Jörn Lötsch , Khayal Gasimli , Sebastian Malkusch , Lisa Hahnefeld , Carlo Angioni , Yannick Schreiber , Sandra Trautmann , Saskia Wedel , Dominique Thomas , Nerea Ferreiros Bouzas , Christian H Brandts , Benjamin Schnappauf , Christine Solbach , Gerd Geisslinger , Marco Sisignano

SPMs exert anti-inflammatory and pro-resolving effects through positive allosteric modulation of the prostaglandin EP4 receptor.

Proceedings of the National Academy of Sciences of the United States of America
Avec: Mohamad Wessam Alnouri , Kenneth Anthony Roquid , Rémy Bonnavion , Haaglim Cho , Jan Heering , Jeonghyeon Kwon , Yannick Jäger , ShengPeng Wang , Stefan Günther , Nina Wettschureck , Gerd Geisslinger , Robert Gurke , Christa E Müller , Ewgenij Proschak , Stefan Offermanns

The endocannabinoid anandamide has an anti-inflammatory effect on CCL2 expression in vascular smooth muscle cells.

Basic research in cardiology
Avec: Beatrice Pflüger-Müller , James A Oo , Jan Heering , Timothy Warwick , Ewgenij Proschak , Stefan Günther , Mario Looso , Flávia Rezende , Christian Fork , Gerd Geisslinger , Dominique Thomas , Robert Gurke , Dieter Steinhilber , Marcel Schulz , Matthias S Leisegang , Ralf P Brandes

Alox12/15 Deficiency Exacerbates, While Lipoxin A

Frontiers in immunology
Avec: Alexander Queck , Annika F Fink , Evelyn Sirait-Fischer , Sabrina Rüschenbaum , Dominique Thomas , Ryan G Snodgrass , Gerd Geisslinger , Hideo A Baba , Jonel Trebicka , Stefan Zeuzem , Andreas Weigert , Christian M Lange , Bernhard Brüne

The Lipid Receptor G2A (GPR132) Mediates Macrophage Migration in Nerve Injury-Induced Neuropathic Pain.

Cells
Avec: Tabea Osthues , Béla Zimmer , Vittoria Rimola , Kevin Klann , Karin Schilling , Praveen Mathoor , Carlo Angioni , Andreas Weigert , Gerd Geisslinger , Christian Münch , Klaus Scholich , Marco Sisignano

High Glucosylceramides and Low Anandamide Contribute to Sensory Loss and Pain in Parkinson's Disease.

Movement disorders : official journal of the Movement Disorder Society
Avec: Katharina Klatt-Schreiner , Lucie Valek , Jun-Suk Kang , Alexander Khlebtovsky , Sandra Trautmann , Lisa Hahnefeld , Yannick Schreiber , Robert Gurke , Dominique Thomas , Annett Wilken-Schmitz , Sabine Wicker , Georg Auburger , Gerd Geisslinger , Jörn Lötsch , Waltraud Pfeilschifter , Ruth Djaldetti , Irmgard Tegeder

Implementation of lipidomics in clinical routine: Can fluoride/citrate blood sampling tubes improve preanalytical stability?

Talanta
Avec: Lisa Hahnefeld , Robert Gurke , Dominique Thomas , Yannick Schreiber , Stephan M G Schäfer , Sandra Trautmann , Isabel Faria Snodgrass , Daniel Kratz , Gerd Geisslinger , Nerea Ferreirós

Tumors Provoke Inflammation and Perineural Microlesions at Adjacent Peripheral Nerves.

Cells
Avec: Jennifer Cohnen , Lisa Kornstädt , Lisa Hahnefeld , Nerea Ferreiros , Sandra Pierre , Ulrike Koehl , Thomas Deller , Gerd Geisslinger , Klaus Scholich

Role of ceramide synthase 2 in G-CSF signaling and G-CSF-R translocation into detergent-resistant membranes.

Scientific reports
Avec: Jennifer Kurz , Julia Barthelmes , Leonard Blum , Thomas Ulshöfer , Marthe-Susanna Wegner , Nerea Ferreirós , Luise Roser , Gerd Geisslinger , Sabine Grösch , Susanne Schiffmann

GPER1 influences cellular homeostasis and cytostatic drug resistance via influencing long chain ceramide synthesis in breast cancer cells.

The international journal of biochemistry & cell biology
Avec: Marthe-Susanna Wegner , Lisa Gruber , Nina Schömel , Sandra Trautmann , Sebastian Brachtendorf , Dominik Fuhrmann , Yannick Schreiber , Catherine Olesch , Bernhard Brüne , Gerd Geisslinger , Sabine Grösch

Thromboxane-Induced α-CGRP Release from Peripheral Neurons Is an Essential Positive Feedback Loop in Capsaicin-Induced Neurogenic Inflammation.

The Journal of investigative dermatology
Avec: Neda Tarighi , Dominic Menger , Sandra Pierre , Lisa Kornstädt , Dominique Thomas , Nerea Ferreirós , Rolf M Nüsing , Gerd Geisslinger , Klaus Scholich

AGMO Inhibitor Reduces 3T3-L1 Adipogenesis.

Cells
Avec: Caroline Fischer , Annett Wilken-Schmitz , Victor Hernandez-Olmos , Ewgenij Proschak , Holger Stark , Ingrid Fleming , Andreas Weigert , Manuela Thurn , Martine Hofmann , Ernst R Werner , Gerd Geisslinger , Ellen Niederberger , Katrin Watschinger , Irmgard Tegeder

4 Ds in health research-working together toward rapid precision medicine.

EMBO molecular medicine
Avec: Ellen Niederberger , Michael J Parnham , Jochen Maas , Gerd Geisslinger

The immunomodulatory potential of the arylmethylaminosteroid sc1o.

Journal of molecular medicine (Berlin, Germany)
Avec: Leonard Blum , Thomas Ulshöfer , Marina Henke , Reimar Krieg , Isabell Berneburg , Gerd Geisslinger , Katja Becker , Michael J Parnham , Susanne Schiffmann

The Roles of Long-Term Hyperhomocysteinemia and Micronutrient Supplementation in the

Frontiers in aging neuroscience
Avec: Hendrik Nieraad , Natasja de Bruin , Olga Arne , Martine C J Hofmann , Nina Pannwitz , Eduard Resch , Sonja Luckhardt , Ann-Kathrin Schneider , Sandra Trautmann , Yannick Schreiber , Robert Gurke , Michael J Parnham , Uwe Till , Gerd Geisslinger

A method for the rational selection of drug repurposing candidates from multimodal knowledge harmonization.

Scientific reports
Avec: Bruce Schultz , Andrea Zaliani , Christian Ebeling , Jeanette Reinshagen , Denisa Bojkova , Vanessa Lage-Rupprecht , Reagon Karki , Sören Lukassen , Yojana Gadiya , Neal G Ravindra , Sayoni Das , Shounak Baksi , Daniel Domingo-Fernández , Manuel Lentzen , Mark Strivens , Tamara Raschka , Jindrich Cinatl , Lauren Nicole DeLong , Phil Gribbon , Gerd Geisslinger , Sandra Ciesek , David van Dijk , Steve Gardner , Alpha Tom Kodamullil , Holger Fröhlich , Manuel Peitsch , Marc Jacobs , Julia Hoeng , Roland Eils , Carsten Claussen , Martin Hofmann-Apitius

Mitofusin 2 Deficiency Causes Pro-Inflammatory Effects in Human Primary Macrophages.

Frontiers in immunology
Avec: Vera Khodzhaeva , Yannick Schreiber , Gerd Geisslinger , Ralf P Brandes , Bernhard Brüne , Dmitry Namgaladze

SAFit2 reduces neuroinflammation and ameliorates nerve injury-induced neuropathic pain.

Journal of neuroinflammation
Avec: Saskia Wedel , Praveen Mathoor , Oliver Rauh , Tim Heymann , Cosmin I Ciotu , Dominik C Fuhrmann , Michael J M Fischer , Andreas Weigert , Natasja de Bruin , Felix Hausch , Gerd Geisslinger , Marco Sisignano

Meloxicam treatment disrupts the regional structure of innate inflammation sites by targeting the pro-inflammatory effects of prostanoids.

British journal of pharmacology
Avec: Tim J Schäufele , Anja Kolbinger , Joschua Friedel , Robert Gurke , Gerd Geisslinger , Andreas Weigert , Sandra Pierre , Klaus Scholich

Hypoxia induced deregulation of sphingolipids in colon cancer is a prognostic marker for patient outcome.

Biochimica et biophysica acta. Molecular basis of disease
Avec: Khadija El Hindi , Sebastian Brachtendorf , Jennifer C Hartel , Christoph Renné , Kerstin Birod , Karin Schilling , Sandra Labocha , Dominique Thomas , Nerea Ferreirós , Lisa Hahnefeld , Erika Dorochow , Domenico Del Turco , Thomas Deller , Klaus Scholich , Dominik C Fuhrmann , Andreas Weigert , Bernhard Brüne , Gerd Geisslinger , Ilka Wittig , Karl-Heinrich Link , Sabine Grösch

Unraveling the Pharmacological Potential of Lichen Extracts in the Context of Cancer and Inflammation With a Broad Screening Approach.

Frontiers in pharmacology
Avec: Rebecca Ingelfinger , Marina Henke , Luise Roser , Thomas Ulshöfer , Anjuli Calchera , Garima Singh , Michael J Parnham , Gerd Geisslinger , Robert Fürst , Imke Schmitt , Susanne Schiffmann

Design, Synthesis, and Structure-Activity Relationship Studies of Dual Inhibitors of Soluble Epoxide Hydrolase and 5-Lipoxygenase.

Journal of medicinal chemistry
Avec: Kerstin Hiesinger , Jan S Kramer , Sandra Beyer , Timon Eckes , Steffen Brunst , Cathrin Flauaus , Sandra K Wittmann , Lilia Weizel , Astrid Kaiser , Simon B M Kretschmer , Sven George , Carlo Angioni , Jan Heering , Gerd Geisslinger , Manfred Schubert-Zsilavecz , Achim Schmidtko , Denys Pogoryelov , Josef Pfeilschifter , Bettina Hofmann , Dieter Steinhilber , Stephanie Schwalm , Ewgenij Proschak

Lysophospholipids Contribute to Oxaliplatin-Induced Acute Peripheral Pain.

The Journal of neuroscience : the official journal of the Society for Neuroscience
Avec: Vittoria Rimola , Lisa Hahnefeld , Junli Zhao , Changyu Jiang , Carlo Angioni , Yannick Schreiber , Tabea Osthues , Sandra Pierre , Gerd Geisslinger , Ru-Rong Ji , Klaus Scholich , Marco Sisignano

Effects of Alzheimer-Like Pathology on Homocysteine and Homocysteic Acid Levels-An Exploratory In Vivo Kinetic Study.

International journal of molecular sciences
Avec: Hendrik Nieraad , Natasja de Bruin , Olga Arne , Martine C J Hofmann , Robert Gurke , Dominik Schmidt , Marcel Ritter , Michael J Parnham , Gerd Geisslinger

A validated LC-MS/MS method for the determination of homocysteic acid in biological samples.

Journal of pharmaceutical and biomedical analysis
Avec: R Gurke , D Schmidt , D Thomas , S C Fleck , G Geisslinger , N Ferreirós

Promoter Activation in Δhfq Mutants as an Efficient Tool for Specialized Metabolite Production Enabling Direct Bioactivity Testing.

Angewandte Chemie (International ed. in English)
Avec: Edna Bode , Antje K Heinrich , Merle Hirschmann , Desalegne Abebew , Yan-Ni Shi , Tien Duy Vo , Frank Wesche , Yi-Ming Shi , Peter Grün , Svenja Simonyi , Nadine Keller , Yvonne Engel , Sebastian Wenski , Reuel Bennet , Sophie Beyer , Iris Bischoff , Anthony Buaya , Sophie Brandt , Ibrahim Cakmak , Harun Çimen , Simone Eckstein , Denia Frank , Robert Fürst , Martin Gand , Gerd Geisslinger , Selcuk Hazir , Marina Henke , Ralf Heermann , Virginie Lecaudey , Wilhelm Schäfer , Susanne Schiffmann , Anja Schüffler , Rebecca Schwenk , Marisa Skaljac , Eckhard Thines , Marco Thines , Thomas Ulshöfer , Andreas Vilcinskas , Thomas A Wichelhaus , Helge B Bode

The histone demethylase Jarid1b mediates angiotensin II-induced endothelial dysfunction by controlling the 3'UTR of soluble epoxide hydrolase.

Acta physiologica (Oxford, England)
Avec: Andrea E Vasconez , Patrick Janetzko , James A Oo , Beatrice Pflüger-Müller , Corina Ratiu , Lunda Gu , Kristian Helin , Gerd Geisslinger , Ingrid Fleming , Katrin Schröder , Christian Fork , Ralf P Brandes , Matthias S Leisegang

Inhibitors of Oxidative Phosphorylation Modulate Astrocyte Inflammatory Responses through AMPK-Dependent Ptgs2 mRNA Stabilization.

Cells
Avec: Alina Astakhova , Dmitry Chistyakov , Dominique Thomas , Gerd Geisslinger , Bernhard Brüne , Marina Sergeeva , Dmitry Namgaladze

Omega-3 and -6 fatty acid plasma levels are not associated with liver cirrhosis-associated systemic inflammation.

PloS one
Avec: Katharina Maria Schwarzkopf , Alexander Queck , Dominique Thomas , Carlo Angioni , Chengcong Cai , Ylva Freygang , Sabrina Rüschenbaum , Gerd Geisslinger , Stefan Zeuzem , Christoph Welsch , Christian Markus Lange

Ceramides as Novel Disease Biomarkers.

Trends in molecular medicine
Avec: Jennifer Kurz , Michael J Parnham , Gerd Geisslinger , Susanne Schiffmann

Pharmacological plasticity-How do you hit a moving target?

Pharmacology research & perspectives
Avec: Michael J Parnham , Gerd Geisslinger

UGCG overexpression leads to increased glycolysis and increased oxidative phosphorylation of breast cancer cells.

Scientific reports
Avec: Nina Schömel , Lisa Gruber , Stephanie J Alexopoulos , Sandra Trautmann , Ellen M Olzomer , Frances L Byrne , Kyle L Hoehn , Robert Gurke , Dominique Thomas , Nerea Ferreirós , Gerd Geisslinger , Marthe-Susanna Wegner

Rab27a Contributes to the Processing of Inflammatory Pain in Mice.

Cells
Avec: Tilman Gross , Gesine Wack , Katharina M J Syhr , Tanya Tolmachova , Miguel C Seabra , Gerd Geisslinger , Ellen Niederberger , Achim Schmidtko , Wiebke Kallenborn-Gerhardt

Exercise-Induced Changes in Bioactive Lipids Might Serve as Potential Predictors of Post-Exercise Hypotension. A Pilot Study in Healthy Volunteers.

Cells
Avec: Miriam C Wolters , Julia Schmetzer , Christine V Möser , Lisa Hahnefeld , Carlo Angioni , Dominique Thomas , Nerea Ferreirós , Gerd Geisslinger , Ellen Niederberger

Increased glucosylceramide production leads to decreased cell energy metabolism and lowered tumor marker expression in non-cancerous liver cells.

Cellular and molecular life sciences : CMLS
Avec: Marthe-Susanna Wegner , Nina Schömel , Ellen M Olzomer , Sandra Trautmann , Catherine Olesch , Frances L Byrne , Bernhard Brüne , Robert Gurke , Nerea Ferreirós , Andreas Weigert , Gerd Geisslinger , Kyle L Hoehn

Increased Fat Taste Preference in Progranulin-Deficient Mice.

Nutrients
Avec: Lana Schumann , Annett Wilken-Schmitz , Sandra Trautmann , Alexandra Vogel , Yannick Schreiber , Lisa Hahnefeld , Robert Gurke , Gerd Geisslinger , Irmgard Tegeder

Contribution of cyclooxygenase-1-dependent prostacyclin synthesis to bradykinin-induced dermal extravasation.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Avec: Michael Krybus , Marc Sieradzki , Ehsan Fahimi , Sara Metry , Rolf Nüsing , Gerd Geisslinger , Irina Steiner , Thomas Daldrup , Matthias Lehr , Georg Kojda

Post-mortem changes of prostanoid concentrations in tissues of mice: Impact of fast cervical dislocation and dissection delay.

Prostaglandins & other lipid mediators
Avec: D Kratz , A Wilken-Schmitz , A Sens , L Hahnefeld , K Scholich , G Geisslinger , R Gurke , D Thomas

Metabolomic and lipidomic fingerprints in inflammatory skin diseases - Systemic illumination of atopic dermatitis, hidradenitis suppurativa and plaque psoriasis.

Clinical immunology (Orlando, Fla.)
Avec: S Rischke , S M G Schäfer , A König , T Ickelsheimer , M Köhm , L Hahnefeld , A Zaliani , K Scholich , A Pinter , G Geisslinger , F Behrens , R Gurke

Omics and Multi-Omics Analysis for the Early Identification and Improved Outcome of Patients with Psoriatic Arthritis.

Biomedicines
Avec: Robert Gurke , Annika Bendes , John Bowes , Michaela Koehm , Richard M Twyman , Anne Barton , Dirk Elewaut , Carl Goodyear , Lisa Hahnefeld , Rainer Hillenbrand , Ewan Hunter , Mark Ibberson , Vassilios Ioannidis , Sabine Kugler , Rik J Lories , Eduard Resch , Stefan Rüping , Klaus Scholich , Jochen M Schwenk , James C Waddington , Phil Whitfield , Gerd Geisslinger , Oliver FitzGerald , Frank Behrens , Stephen R Pennington , Auteur inconnu

The FKBP51 Inhibitor SAFit2 Restores the Pain-Relieving C16 Dihydroceramide after Nerve Injury.

International journal of molecular sciences
Avec: Saskia Wedel , Lisa Hahnefeld , Mohamad Wessam Alnouri , Stefan Offermanns , Felix Hausch , Gerd Geisslinger , Marco Sisignano

Knock-Out of IKKepsilon Ameliorates Atherosclerosis and Fatty Liver Disease by Alterations of Lipid Metabolism in the PCSK9 Model in Mice.

International journal of molecular sciences
Avec: Ulrike Weiss , Eleonora Mungo , Michelle Haß , Denis Benning , Robert Gurke , Lisa Hahnefeld , Erika Dorochow , Jessica Schlaudraff , Tobias Schmid , Silvia Kuntschar , Sofie Meyer , Rebekka Medert , Marc Freichel , Gerd Geisslinger , Ellen Niederberger

Healthy plasma lipidomic signatures depend on sex, age, body mass index, and contraceptives but not perceived stress.

American journal of physiology. Cell physiology
Avec: Lisa Hahnefeld , Juliane Hackel , Sandra Trautmann , Carlo Angioni , Yannick Schreiber , Robert Gurke , Dominique Thomas , Sabine Wicker , Gerd Geisslinger , Irmgard Tegeder

In-vitro safety and off-target profile of the anti-parasitic arylmethylaminosteroid 1o.

Scientific reports
Avec: Leonard Blum , Sheraz Gul , Thomas Ulshöfer , Marina Henke , Reimar Krieg , Isabell Berneburg , Dominique Thomas , Sandra Trautmann , Jennifer Kurz , Joachim Geyer , Gerd Geisslinger , Katja Becker , Michael J Parnham , Susanne Schiffmann

Natural antiviral compound silvestrol modulates human monocyte-derived macrophages and dendritic cells.

Journal of cellular and molecular medicine
Avec: Leonard Blum , Gerd Geisslinger , Michael J Parnham , Arnold Grünweller , Susanne Schiffmann

Neuropathic and cAMP-induced pain behavior is ameliorated in mice lacking CNGB1.

Neuropharmacology
Avec: Wiebke Kallenborn-Gerhardt , Katharina Metzner , Ruirui Lu , Jonas Petersen , Miriam S Kuth , Sandra Heine , Oliver Drees , Mandy Paul , Elvir Becirovic , Lea Kennel , Cathrin Flauaus , Tilman Gross , Gesine Wack , Stephan W Hohmann , Dina Nemirovski , Domenico Del Turco , Martin Biel , Gerd Geisslinger , Stylianos Michalakis , Achim Schmidtko

Ether lipid and sphingolipid expression patterns are estrogen receptor-dependently altered in breast cancer cells.

The international journal of biochemistry & cell biology
Avec: Lisa Hahnefeld , Lisa Gruber , Nina Schömel , Caroline Fischer , Peter Mattjus , Robert Gurke , Martina Beretta , Nerea Ferreirós , Gerd Geisslinger , Marthe-Susanna Wegner

[Generating knowledge from complex data sets in human experimental pain research].

Schmerz (Berlin, Germany)
Avec: Jörn Lötsch , Gerd Geisslinger , Carmen Walter

The Lipid Status in Patients with Ulcerative Colitis: Sphingolipids are Disease-Dependent Regulated.

Journal of clinical medicine
Avec: Sarah Bazarganipour , Johannes Hausmann , Stephanie Oertel , Khadija El-Hindi , Sebastian Brachtendorf , Irina Blumenstein , Alica Kubesch , Kathrin Sprinzl , Kerstin Birod , Lisa Hahnefeld , Sandra Trautmann , Dominique Thomas , Eva Herrmann , Gerd Geisslinger , Susanne Schiffmann , Sabine Grösch

Selective inactivation of hypomethylating agents by SAMHD1 provides a rationale for therapeutic stratification in AML.

Nature communications
Avec: Thomas Oellerich , Constanze Schneider , Dominique Thomas , Kirsten M Knecht , Olga Buzovetsky , Lars Kaderali , Christoph Schliemann , Hanibal Bohnenberger , Linus Angenendt , Wolfgang Hartmann , Eva Wardelmann , Tamara Rothenburger , Sebastian Mohr , Sebastian Scheich , Federico Comoglio , Anne Wilke , Philipp Ströbel , Hubert Serve , Martin Michaelis , Nerea Ferreirós , Gerd Geisslinger , Yong Xiong , Oliver T Keppler , Jindrich Cinatl

Computer-Aided Selective Optimization of Side Activities of Talinolol.

ACS medicinal chemistry letters
Avec: Kerstin Hiesinger , Jan S Kramer , Janosch Achenbach , Daniel Moser , Julia Weber , Sandra K Wittmann , Christophe Morisseau , Carlo Angioni , Gerd Geisslinger , Astrid S Kahnt , Astrid Kaiser , Anna Proschak , Dieter Steinhilber , Denys Pogoryelov , Karen Wagner , Bruce D Hammock , Ewgenij Proschak

Targeted lipidomics reveal derangement of ceramides in major depression and bipolar disorder.

Metabolism: clinical and experimental
Avec: Nathalie Brunkhorst-Kanaan , Katharina Klatt-Schreiner , Juliane Hackel , Katrin Schröter , Sandra Trautmann , Lisa Hahnefeld , Sabine Wicker , Andreas Reif , Dominique Thomas , Gerd Geisslinger , Sarah Kittel-Schneider , Irmgard Tegeder

Mast cell tetrahydrobiopterin contributes to itch in mice.

Journal of cellular and molecular medicine
Avec: Katja Zschiebsch , Caroline Fischer , Annett Wilken-Schmitz , Gerd Geisslinger , Keith Channon , Katrin Watschinger , Irmgard Tegeder

Sphingosine-1-phosphate (S1P) induces potent anti-inflammatory effects in vitro and in vivo by S1P receptor 4-mediated suppression of 5-lipoxygenase activity.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Avec: Jasmin Fettel , Benjamin Kühn , Nathalie A Guillen , Duran Sürün , Marcus Peters , Rebekka Bauer , Carlo Angioni , Gerd Geisslinger , Frank Schnütgen , Dagmar Meyer Zu Heringdorf , Oliver Werz , Patrick Meybohm , Kai Zacharowski , Dieter Steinhilber , Jessica Roos , Thorsten J Maier

Hyperhomocysteinemia: Metabolic Role and Animal Studies with a Focus on Cognitive Performance and Decline-A Review.

Biomolecules
Avec: Hendrik Nieraad , Nina Pannwitz , Natasja de Bruin , Gerd Geisslinger , Uwe Till

Differences between intrinsic and acquired nucleoside analogue resistance in acute myeloid leukaemia cells.

Journal of experimental & clinical cancer research : CR
Avec: Tamara Rothenburger , Dominique Thomas , Yannick Schreiber , Paul R Wratil , Tamara Pflantz , Kirsten Knecht , Katie Digianantonio , Joshua Temple , Constanze Schneider , Hanna-Mari Baldauf , Katie-May McLaughlin , Florian Rothweiler , Berna Bilen , Samira Farmand , Denisa Bojkova , Rui Costa , Nerea Ferreirós , Gerd Geisslinger , Thomas Oellerich , Yong Xiong , Oliver T Keppler , Mark N Wass , Martin Michaelis , Jindrich Cinatl

Prodromal sensory neuropathy in Pink1

Neuropathology and applied neurobiology
Avec: Lucie Valek , Bao Tran , Annett Wilken-Schmitz , Sandra Trautmann , Juliana Heidler , Tobias Schmid , Bernhard Brüne , Dominique Thomas , Thomas Deller , Gerd Geisslinger , Georg Auburger , Irmgard Tegeder

Sapropterin (BH4) Aggravates Autoimmune Encephalomyelitis in Mice.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
Avec: Katja Schmitz , Sandra Trautmann , Lisa Hahnefeld , Caroline Fischer , Yannick Schreiber , Annett Wilken-Schmitz , Robert Gurke , Robert Brunkhorst , Ernst R Werner , Katrin Watschinger , Sabine Wicker , Dominique Thomas , Gerd Geisslinger , Irmgard Tegeder

A SARS-CoV-2 cytopathicity dataset generated by high-content screening of a large drug repurposing collection.

Scientific data
Avec: Bernhard Ellinger , Denisa Bojkova , Andrea Zaliani , Jindrich Cinatl , Carsten Claussen , Sandra Westhaus , Oliver Keminer , Jeanette Reinshagen , Maria Kuzikov , Markus Wolf , Gerd Geisslinger , Philip Gribbon , Sandra Ciesek

Validation of highly selective sphingosine kinase 2 inhibitors SLM6031434 and HWG-35D as effective anti-fibrotic treatment options in a mouse model of tubulointerstitial fibrosis.

Cellular signalling
Avec: Stephanie Schwalm , Sandra Beyer , Redona Hafizi , Sandra Trautmann , Gerd Geisslinger , David R Adams , Susan Pyne , Nigel Pyne , Liliana Schaefer , Andrea Huwiler , Josef Pfeilschifter

Sphingolipid and Endocannabinoid Profiles in Adult Attention Deficit Hyperactivity Disorder.

Biomedicines
Avec: Nathalie Brunkhorst-Kanaan , Sandra Trautmann , Yannick Schreiber , Dominique Thomas , Sarah Kittel-Schneider , Robert Gurke , Gerd Geisslinger , Andreas Reif , Irmgard Tegeder

Proton-Sensing GPCRs in Health and Disease.

Cells
Avec: Marco Sisignano , Michael J M Fischer , Gerd Geisslinger

Lecanoric acid mediates anti-proliferative effects by an M phase arrest in colon cancer cells.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Avec: Luise A Roser , Pelin Erkoc , Rebecca Ingelfinger , Marina Henke , Thomas Ulshöfer , Ann-Kathrin Schneider , Volker Laux , Gerd Geisslinger , Imke Schmitt , Robert Fürst , Susanne Schiffmann

Ca

Science advances
Avec: Josef Shin , Lora Kovacheva , Dominique Thomas , Strahinja Stojanovic , Christopher J Knowlton , Johanna Mankel , Johannes Boehm , Navid Farassat , Carlos Paladini , Jörg Striessnig , Carmen C Canavier , Gerd Geisslinger , Jochen Roeper

Formation, Signaling and Occurrence of Specialized Pro-Resolving Lipid Mediators-What is the Evidence so far?

Frontiers in pharmacology
Avec: Nils Helge Schebb , Hartmut Kühn , Astrid S Kahnt , Katharina M Rund , Valerie B O'Donnell , Nicolas Flamand , Marc Peters-Golden , Per-Johan Jakobsson , Karsten H Weylandt , Nadine Rohwer , Robert C Murphy , Gerd Geisslinger , Garret A FitzGerald , Julien Hanson , Claes Dahlgren , Mohamad Wessam Alnouri , Stefan Offermanns , Dieter Steinhilber

Machine learning identifies right index finger tenderness as key signal of DAS28-CRP based psoriatic arthritis activity.

Scientific reports
Avec: Samuel Rischke , Sorwe Mojtahed Poor , Robert Gurke , Lisa Hahnefeld , Michaela Köhm , Alfred Ultsch , Gerd Geisslinger , Frank Behrens , Jörn Lötsch

Rethinking the use of NSAIDs in early acute pain.

Trends in pharmacological sciences
Avec: Marco Sisignano , Gerd Geisslinger

Differential Lipidomics, Metabolomics and Immunological Analysis of Alcoholic and Non-Alcoholic Steatohepatitis in Mice.

International journal of molecular sciences
Avec: Erika Dorochow , Nico Kraus , Nicolas Chenaux-Repond , Sandra Pierre , Anja Kolbinger , Gerd Geisslinger , Cristina Ortiz , Christoph Welsch , Jonel Trebicka , Robert Gurke , Lisa Hahnefeld , Sabine Klein , Klaus Scholich

Impact of different classes of immune-modulating treatments on B cell-related and T cell-related immune response before and after COVID-19 booster vaccination in patients with immune-mediated diseases and primary immunodeficiency: a cohort study.

RMD open
Avec: Michaela Koehm , Maximilian Klippstein , Stephanie Dauth , Konstantin Hallmann , Niko Kohmer , Harald Burkhardt , Sandra Ciesek , Gerd Geisslinger , Holger F Rabenau , Frank Behrens

Eosinophil-derived IL-4 is necessary to establish the inflammatory structure in innate inflammation.

EMBO molecular medicine
Avec: Anja Kolbinger , Tim J Schäufele , Hanna Steigerwald , Joschua Friedel , Sandra Pierre , Gerd Geisslinger , Klaus Scholich

Lysophosphatidic Acid Receptors LPAR5 and LPAR2 Inversely Control Hydroxychloroquine-Evoked Itch and Scratching in Mice.

International journal of molecular sciences
Avec: Caroline Fischer , Yannick Schreiber , Robert Nitsch , Johannes Vogt , Dominique Thomas , Gerd Geisslinger , Irmgard Tegeder

12/15-Lipoxygenase choreographs the resolution of IgG-mediated skin inflammation.

Journal of autoimmunity
Avec: Tanya Sezin , Nerea Ferreirós , Malin Jennrich , Khoroljav Ochirbold , Malte Seutter , Claudia Attah , Sadegh Mousavi , Detlef Zillikens , Gerd Geisslinger , Christian D Sadik

Exploring CYP2J2: lipid mediators, inhibitors and therapeutic implications.

Drug discovery today
Avec: Marco Sisignano , Dieter Steinhilber , Michael J Parnham , Gerd Geisslinger

The omega-3 lipid 17,18-EEQ sensitizes TRPV1 and TRPA1 in sensory neurons through the prostacyclin receptor (IP).

Neuropharmacology
Avec: Stephan M G Schäfer , Maksim Sendetski , Carlo Angioni , Rolf Nüsing , Gerd Geisslinger , Klaus Scholich , Marco Sisignano

Determination of endocannabinoids and endocannabinoid-like substances in human K3EDTA plasma - LC-MS/MS method validation and pre-analytical characteristics.

Talanta
Avec: R Gurke , D Thomas , Y Schreiber , S M G Schäfer , S C Fleck , G Geisslinger , N Ferreirós

Réseau de co-auteurs

Dominique Thomas 26 collaborations
Lisa Hahnefeld 24 collaborations
Robert Gurke 21 collaborations
Sandra Trautmann 16 collaborations
Klaus Scholich 15 collaborations
Carlo Angioni 14 collaborations
Yannick Schreiber 14 collaborations
Marco Sisignano 13 collaborations
Irmgard Tegeder 12 collaborations
Nerea Ferreirós 12 collaborations
Michael J Parnham 11 collaborations
Sandra Pierre 10 collaborations
Annett Wilken-Schmitz 9 collaborations
Susanne Schiffmann 9 collaborations
Dieter Steinhilber 8 collaborations
Ellen Niederberger 8 collaborations
Andreas Weigert 7 collaborations
Bernhard Brüne 7 collaborations
Ewgenij Proschak 6 collaborations
Jörn Lötsch 6 collaborations
Marthe-Susanna Wegner 6 collaborations
Saskia Wedel 6 collaborations
Thomas Ulshöfer 6 collaborations
Jan Heering 5 collaborations
Nina Schömel 5 collaborations
Sabine Grösch 5 collaborations
Natasja de Bruin 5 collaborations
G Geisslinger 5 collaborations
R Gurke 5 collaborations
Caroline Fischer 5 collaborations
Marina Henke 5 collaborations
Astrid S Kahnt 4 collaborations
Eduard Resch 4 collaborations
Ralf P Brandes 4 collaborations
Erika Dorochow 4 collaborations
Frank Behrens 4 collaborations
D Thomas 4 collaborations
Sabine Wicker 4 collaborations
Leonard Blum 4 collaborations
Jindrich Cinatl 4 collaborations
Sandra K Wittmann 3 collaborations
Thorsten J Maier 3 collaborations
Moritz Möller 3 collaborations
Andreas Reif 3 collaborations
Christine V Möser 3 collaborations
Lisa Kornstädt 3 collaborations
Vittoria Rimola 3 collaborations
Kai Zacharowski 3 collaborations
Tabea Osthues 3 collaborations
Béla Zimmer 3 collaborations
Felix Hausch 3 collaborations
Tobias Schmid 3 collaborations
S M G Schäfer 3 collaborations
Mohamad Wessam Alnouri 3 collaborations
Stefan Offermanns 3 collaborations
Thomas Deller 3 collaborations
Jennifer Kurz 3 collaborations
Lisa Gruber 3 collaborations
Sebastian Brachtendorf 3 collaborations
Katrin Watschinger 3 collaborations
Hendrik Nieraad 3 collaborations
Denisa Bojkova 3 collaborations
Sandra Ciesek 3 collaborations
Anja Kolbinger 3 collaborations
Robert Fürst 3 collaborations
Achim Schmidtko 3 collaborations
Tamara Göbel 2 collaborations
Lilia Weizel 2 collaborations
Manfred Schubert-Zsilavecz 2 collaborations
Ulrike Weiss 2 collaborations
Stefanie C Fleck 2 collaborations
Manuela Thurn 2 collaborations
Sebastian Malkusch 2 collaborations
Katja Schmitz 2 collaborations
Daniel Kratz 2 collaborations
Bettina Hofmann 2 collaborations
Jessica Roos 2 collaborations
Tim Heymann 2 collaborations
Alexandra Vogel 2 collaborations
Sabine Kugler 2 collaborations
Stephanie Dauth 2 collaborations
Volker Laux 2 collaborations
Michaela Köhm 2 collaborations
Eleonora Mungo 2 collaborations
A Sens 2 collaborations
A König 2 collaborations
A Pinter 2 collaborations
Maksim Sendetski 2 collaborations
Ru-Rong Ji 2 collaborations
Stefan Günther 2 collaborations
Beatrice Pflüger-Müller 2 collaborations
James A Oo 2 collaborations
Christian Fork 2 collaborations
Matthias S Leisegang 2 collaborations
Alexander Queck 2 collaborations
Sabrina Rüschenbaum 2 collaborations
Jonel Trebicka 2 collaborations
Stefan Zeuzem 2 collaborations
Karin Schilling 2 collaborations
Praveen Mathoor 2 collaborations
Katharina Klatt-Schreiner 2 collaborations
Lucie Valek 2 collaborations
Georg Auburger 2 collaborations
Stephan M G Schäfer 2 collaborations
Luise Roser 2 collaborations
Catherine Olesch 2 collaborations
Ingrid Fleming 2 collaborations
Ernst R Werner 2 collaborations
Reimar Krieg 2 collaborations
Isabell Berneburg 2 collaborations
Katja Becker 2 collaborations
Olga Arne 2 collaborations
Martine C J Hofmann 2 collaborations
Nina Pannwitz 2 collaborations
Ann-Kathrin Schneider 2 collaborations
Uwe Till 2 collaborations
Andrea Zaliani 2 collaborations
Jeanette Reinshagen 2 collaborations
Carsten Claussen 2 collaborations
Dmitry Namgaladze 2 collaborations
Dominik C Fuhrmann 2 collaborations
Michael J M Fischer 2 collaborations
Tim J Schäufele 2 collaborations
Joschua Friedel 2 collaborations
Kerstin Birod 2 collaborations
Domenico Del Turco 2 collaborations
Rebecca Ingelfinger 2 collaborations
Imke Schmitt 2 collaborations
Kerstin Hiesinger 2 collaborations
Jan S Kramer 2 collaborations
Sandra Beyer 2 collaborations
Cathrin Flauaus 2 collaborations
Astrid Kaiser 2 collaborations
Denys Pogoryelov 2 collaborations
Josef Pfeilschifter 2 collaborations
Stephanie Schwalm 2 collaborations
S C Fleck 2 collaborations
N Ferreirós 2 collaborations
Christoph Welsch 2 collaborations
Ellen M Olzomer 2 collaborations
Frances L Byrne 2 collaborations
Kyle L Hoehn 2 collaborations
Tilman Gross 2 collaborations
Gesine Wack 2 collaborations
Wiebke Kallenborn-Gerhardt 2 collaborations
Rolf Nüsing 2 collaborations
L Hahnefeld 2 collaborations
K Scholich 2 collaborations
Michaela Koehm 2 collaborations
Juliane Hackel 2 collaborations
Thomas Oellerich 2 collaborations
Constanze Schneider 2 collaborations
Tamara Rothenburger 2 collaborations
Martin Michaelis 2 collaborations
Yong Xiong 2 collaborations
Oliver T Keppler 2 collaborations
Nathalie Brunkhorst-Kanaan 2 collaborations
Sarah Kittel-Schneider 2 collaborations
Olaf Diehl 1 collaboration
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