SPMs exert anti-inflammatory and pro-resolving effects through positive allosteric modulation of the prostaglandin EP4 receptor.
GPCR signaling
allosteric modulation
inflammation
specialized pro-resolving mediators
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
08 Oct 2024
08 Oct 2024
Historique:
medline:
4
10
2024
pubmed:
4
10
2024
entrez:
4
10
2024
Statut:
ppublish
Résumé
Inflammation is a protective response to pathogens and injury. To be effective it needs to be resolved by endogenous mechanisms in order to avoid prolonged and excessive inflammation, which can become chronic. Specialized pro-resolving mediators (SPMs) are a group of lipids derived from omega-3 fatty acids, which can induce the resolution of inflammation. How SPMs exert their anti-inflammatory and pro-resolving effects is, however, not clear. Here, we show that SPMs such as protectins, maresins, and D-series resolvins function as biased positive allosteric modulators (PAM) of the prostaglandin E
Identifiants
pubmed: 39365815
doi: 10.1073/pnas.2407130121
doi:
Substances chimiques
Receptors, Prostaglandin E, EP4 Subtype
0
Anti-Inflammatory Agents
0
Dinoprostone
K7Q1JQR04M
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2407130121Subventions
Organisme : Deutsche Forschungsgemeinschaft (DFG)
ID : CRC1039 204083920
Déclaration de conflit d'intérêts
Competing interests statement:The authors declare no competing interest.