Atrial Myocyte NLRP3/CaMKII Nexus Forms a Substrate for Postoperative Atrial Fibrillation.

Action Potentials Aged Animals Atrial Fibrillation / enzymology Calcium Signaling Calcium-Calmodulin-Dependent Protein Kinase Type 2 / metabolism Cardiac Surgical Procedures / adverse effects Case-Control Studies Cell Line Female Heart Atria / enzymology Heart Rate Humans Inflammasomes / metabolism Inflammation Mediators / metabolism Male Mice Middle Aged Myocytes, Cardiac / enzymology NLR Family, Pyrin Domain-Containing 3 Protein / metabolism Phosphorylation Ryanodine Receptor Calcium Release Channel / metabolism Sarcoplasmic Reticulum / metabolism
CaMKII NLRP3 action potentials atrial fibrillation calcium interleukin sarcoplasmic reticulum

Journal

Circulation research
ISSN: 1524-4571
Titre abrégé: Circ Res
Pays: United States
ID NLM: 0047103

Informations de publication

Date de publication:
25 09 2020
Historique:
pubmed: 9 8 2020
medline: 25 5 2021
entrez: 9 8 2020
Statut: ppublish

Résumé

Postoperative atrial fibrillation (POAF) is a common and troublesome complication of cardiac surgery. POAF is generally believed to occur when postoperative triggers act on a preexisting vulnerable substrate, but the underlying cellular and molecular mechanisms are largely unknown. To identify cellular POAF mechanisms in right atrial samples from patients without a history of atrial fibrillation undergoing open-heart surgery. Multicellular action potentials, membrane ion-currents (perforated patch-clamp), or simultaneous membrane-current (ruptured patch-clamp) and [Ca Preexisting Ca

Identifiants

DOI: 10.1161/CIRCRESAHA.120.316710 PMID: 32762493 PMC: PMC7604886
pubmed: 32762493
doi: 10.1161/CIRCRESAHA.120.316710
pmc: PMC7604886
mid: NIHMS1617239
doi:

Substances chimiques

Inflammasomes 0
Inflammation Mediators 0
NLR Family, Pyrin Domain-Containing 3 Protein 0
NLRP3 protein, human 0
Nlrp3 protein, mouse 0
RyR2 protein, human 0
Ryanodine Receptor Calcium Release Channel 0
ryanodine receptor 2. mouse 0
Calcium-Calmodulin-Dependent Protein Kinase Type 2 EC 2.7.11.17

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1036-1055

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL136389
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL091947
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL131517
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL089598
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL147108
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL117641
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL134824
Pays : United States
Organisme : CIHR
ID : 1484011
Pays : Canada

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Auteurs

Jordi Heijman (J)

Institute of Pharmacology, West German Heart and Vascular Center, University Duisburg-Essen, Essen, Germany (J.H., A.P.M., T.V., C.E.M., M.T., I.H.A.-T., M.G., S.N., D.D.).
Cardiology, Cardiovascular Research Institute Maastricht, Faculty of Health, Medicine, and Life Sciences, Maastricht University, Maastricht, The Netherlands (J.H., H.S.,).

Azinwi Phina Muna (AP)

Institute of Pharmacology, West German Heart and Vascular Center, University Duisburg-Essen, Essen, Germany (J.H., A.P.M., T.V., C.E.M., M.T., I.H.A.-T., M.G., S.N., D.D.).

Tina Veleva (T)

Institute of Pharmacology, West German Heart and Vascular Center, University Duisburg-Essen, Essen, Germany (J.H., A.P.M., T.V., C.E.M., M.T., I.H.A.-T., M.G., S.N., D.D.).

Cristina E Molina (CE)

Institute of Pharmacology, West German Heart and Vascular Center, University Duisburg-Essen, Essen, Germany (J.H., A.P.M., T.V., C.E.M., M.T., I.H.A.-T., M.G., S.N., D.D.).
Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf and DZHK (German Center for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Hamburg, Germany (C.E.M., V.N.).

Henry Sutanto (H)

Cardiology, Cardiovascular Research Institute Maastricht, Faculty of Health, Medicine, and Life Sciences, Maastricht University, Maastricht, The Netherlands (J.H., H.S.,).

Marcel Tekook (M)

Institute of Pharmacology, West German Heart and Vascular Center, University Duisburg-Essen, Essen, Germany (J.H., A.P.M., T.V., C.E.M., M.T., I.H.A.-T., M.G., S.N., D.D.).

Qiongling Wang (Q)

Cardiovascular Research Institute (Q.W., N.L., X.H.T.W.), Baylor College of Medicine, Houston, TX.
Molecular Physiology and Biophysics, Medicine, Pediatrics, Neuroscience, and Center for Space Medicine (Q.W., X.H.T.W.), Baylor College of Medicine, Houston, TX.

Issam H Abu-Taha (IH)

Institute of Pharmacology, West German Heart and Vascular Center, University Duisburg-Essen, Essen, Germany (J.H., A.P.M., T.V., C.E.M., M.T., I.H.A.-T., M.G., S.N., D.D.).

Marcel Gorka (M)

Institute of Pharmacology, West German Heart and Vascular Center, University Duisburg-Essen, Essen, Germany (J.H., A.P.M., T.V., C.E.M., M.T., I.H.A.-T., M.G., S.N., D.D.).

Stephan Künzel (S)

Institute of Pharmacology, West German Heart and Vascular Center, University Duisburg-Essen, Essen, Germany (J.H., A.P.M., T.V., C.E.M., M.T., I.H.A.-T., M.G., S.N., D.D.).
Pharmacology and Toxicology, Medical Faculty, Technische Universität Dresden, Dresden, Germany (S.K., A.E.-A.).

Ali El-Armouche (A)

Pharmacology and Toxicology, Medical Faculty, Technische Universität Dresden, Dresden, Germany (S.K., A.E.-A.).

Hermann Reichenspurner (H)

Cardiovascular Surgery, University Heart Center Hamburg and DZHK (German Center for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Hamburg, Germany (H.R.).

Markus Kamler (M)

Thoracic and Cardiovascular Surgery, West German Heart and Vascular Center Essen, University Hospital Essen, Essen, Germany (M.K.).

Viacheslav Nikolaev (V)

Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf and DZHK (German Center for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Hamburg, Germany (C.E.M., V.N.).

Ursula Ravens (U)

Institute of Experimental Cardiovascular Medicine, University Heart Center Freiburg-Bad Krozingen, University of Freiburg, Freiburg, Germany (U.R.).
Institute of Physiology, Medical Faculty Carl Gustav Carus, Technical University of Dresden, Dresden, Germany (U.R.).

Na Li (N)

Cardiovascular Research Institute (Q.W., N.L., X.H.T.W.), Baylor College of Medicine, Houston, TX.
Medicine (Section of Cardiovascular Research) (N.L.), Baylor College of Medicine, Houston, TX.

Stanley Nattel (S)

Medicine, Montreal Heart Institute and Université de Montréal & Department of Pharmacology and Therapeutics, McGill University Montreal, Canada (S.N.).
IHU LIRYC and Fondation Bordeaux Université, Bordeaux, France (S.N.).

Xander H T Wehrens (XHT)

Cardiovascular Research Institute (Q.W., N.L., X.H.T.W.), Baylor College of Medicine, Houston, TX.
Molecular Physiology and Biophysics, Medicine, Pediatrics, Neuroscience, and Center for Space Medicine (Q.W., X.H.T.W.), Baylor College of Medicine, Houston, TX.

Dobromir Dobrev (D)

Institute of Pharmacology, West German Heart and Vascular Center, University Duisburg-Essen, Essen, Germany (J.H., A.P.M., T.V., C.E.M., M.T., I.H.A.-T., M.G., S.N., D.D.).

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Potentiels de membrane › Potentiels d'action › Atrial Myocyte NLRP3/CaMKII Nexus Forms a...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Atrial Myocyte NLRP3/CaMKII Nexus Forms a...
questionsmedicales.fr › Eucaryotes › Animaux › Atrial Myocyte NLRP3/CaMKII Nexus Forms a...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Troubles du rythme cardiaque › Fibrillation auriculaire › Atrial Myocyte NLRP3/CaMKII Nexus Forms a...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Systèmes de seconds messagers › Signalisation calcique › Atrial Myocyte NLRP3/CaMKII Nexus Forms a...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Calcium-Calmodulin-Dependent Protein Kinases › Calcium-Calmodulin-Dependent Protein Kinase Type 2 › Atrial Myocyte NLRP3/CaMKII Nexus Forms a...
questionsmedicales.fr › Procédures de chirurgie opératoire › Procédures de chirurgie thoracique › Procédures de chirurgie cardiaque › Atrial Myocyte NLRP3/CaMKII Nexus Forms a...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études cas-témoins › Atrial Myocyte NLRP3/CaMKII Nexus Forms a...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Atrial Myocyte NLRP3/CaMKII Nexus Forms a...
questionsmedicales.fr › Système cardiovasculaire › Coeur › Atrium du coeur › Atrial Myocyte NLRP3/CaMKII Nexus Forms a...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Hémodynamique › Rythme cardiaque › Atrial Myocyte NLRP3/CaMKII Nexus Forms a...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Atrial Myocyte NLRP3/CaMKII Nexus Forms a...
questionsmedicales.fr › Structures macromoléculaires › Complexes multiprotéiques › Inflammasomes › Atrial Myocyte NLRP3/CaMKII Nexus Forms a...
questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › Atrial Myocyte NLRP3/CaMKII Nexus Forms a...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Atrial Myocyte NLRP3/CaMKII Nexus Forms a...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Atrial Myocyte NLRP3/CaMKII Nexus Forms a...
questionsmedicales.fr › Cellules › Cellules musculaires › Myocytes cardiaques › Atrial Myocyte NLRP3/CaMKII Nexus Forms a...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Protéines NLR › Protéine-3 de la famille des NLR contenant un domaine pyrine › Atrial Myocyte NLRP3/CaMKII Nexus Forms a...
questionsmedicales.fr › Métabolisme › Phosphorylation › Atrial Myocyte NLRP3/CaMKII Nexus Forms a...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux calciques › Canal de libération du calcium du récepteur à la ryanodine › Atrial Myocyte NLRP3/CaMKII Nexus Forms a...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Réticulum endoplasmique › Réticulum endoplasmique lisse › Réticulum sarcoplasmique › Atrial Myocyte NLRP3/CaMKII Nexus Forms a...