Experimental evidence and physiological significance of the ascorbate passive diffusion through the lipid bilayer.
Ascorbate homeostasis
Passive membrane permeability
Vitamin C
Journal
Chemistry and physics of lipids
ISSN: 1873-2941
Titre abrégé: Chem Phys Lipids
Pays: Ireland
ID NLM: 0067206
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
12
12
2019
revised:
23
04
2020
accepted:
21
07
2020
pubmed:
9
8
2020
medline:
30
6
2021
entrez:
9
8
2020
Statut:
ppublish
Résumé
The diverse range of functions performed by ascorbate in many metabolic processes requires its effective redistribution between various aqueous body compartments. It is believed that this hydrophilic molecule needs protein transporters for crossing the biological membrane barriers. Any effective model reflecting the ascorbate distribution within the body requires bi-directional fluxes, but only the ascorbate transporters facilitating its intake by cells have been identified to date. The cellular efflux of this molecule still lacks proper mechanistic explanation, nevertheless data suggesting possible passive ascorbate transport recently appeared. In the paper, we provide experimental evidences that ascorbate associates efficiently with the lipid bilayer interface and slowly crosses its hydrophobic core. The measured logP
Identifiants
pubmed: 32763228
pii: S0009-3084(20)30081-5
doi: 10.1016/j.chemphyslip.2020.104950
pii:
doi:
Substances chimiques
Lipid Bilayers
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
104950Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.