Effect of ginger (Zingiber officinale) on inflammatory markers: A systematic review and meta-analysis of randomized controlled trials.
Animals
Biomarkers
/ metabolism
C-Reactive Protein
/ metabolism
Dietary Supplements
Zingiber officinale
/ chemistry
Humans
Inflammation
/ metabolism
Inflammation Mediators
/ metabolism
Interleukin-6
/ metabolism
Plant Preparations
/ pharmacology
Randomized Controlled Trials as Topic
Tumor Necrosis Factor-alpha
/ metabolism
C - reactive protein
Ginger
IL-6
Inflammation
TNF-α
Journal
Cytokine
ISSN: 1096-0023
Titre abrégé: Cytokine
Pays: England
ID NLM: 9005353
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
21
04
2020
revised:
10
06
2020
accepted:
25
07
2020
pubmed:
9
8
2020
medline:
15
12
2021
entrez:
9
8
2020
Statut:
ppublish
Résumé
The aim of this systematic review and meta-analysis was to investigate the efficacy of ginger supplementation on circulating levels of C-reactive protein (CRP), high sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-alpha (TNF-α), soluble intercellular adhesion molecule (sICAM), and interleukin-6 (IL-6) concentrations in randomized controlled trials (RCTs). The search included PubMed-Medline, EMBASE, Scopus, Web of Science and Cochrane Library databases to identify randomized clinical trials on the effect of ginger supplementation on circulation levels of CRP, hs-CRP, IL-6, sICAM, and TNF-α published up until February 1st, 2020. We did not restrict articles based on language of publication. Standard mean differences and 95% confidence intervals were calculated for net changes in inflammatory mediators using a random-effects model. Sixteen RCTs comprising 1010 participants were found to be eligible for this meta-analysis. There was a significant reduction of circulating CRP (SMD: -5.11, 95% CI: -7.91, -2.30, I
Identifiants
pubmed: 32763761
pii: S1043-4666(20)30240-4
doi: 10.1016/j.cyto.2020.155224
pii:
doi:
Substances chimiques
Biomarkers
0
Inflammation Mediators
0
Interleukin-6
0
Plant Preparations
0
Tumor Necrosis Factor-alpha
0
C-Reactive Protein
9007-41-4
Types de publication
Journal Article
Meta-Analysis
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
155224Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.