Disability Improvement Is Associated with Less Brain Atrophy Development in Multiple Sclerosis.

Adult Atrophy / pathology Brain / pathology Disease Progression Female Humans Immunologic Factors / therapeutic use Magnetic Resonance Imaging / methods Male Middle Aged Multiple Sclerosis / drug therapy Retrospective Studies

Journal

AJNR. American journal of neuroradiology
ISSN: 1936-959X
Titre abrégé: AJNR Am J Neuroradiol
Pays: United States
ID NLM: 8003708

Informations de publication

Date de publication:
09 2020
Historique:
received: 24 11 2019
accepted: 01 06 2020
pubmed: 9 8 2020
medline: 22 12 2020
entrez: 9 8 2020
Statut: ppublish

Résumé

It is unknown whether deceleration of brain atrophy is associated with disability improvement in patients with MS. Our aim was to investigate whether patients with MS with disability improvement develop less brain atrophy compared with those who progress in disability or remain stable. We followed 980 patients with MS for a mean of 4.8 ± 2.4 years. Subjects were divided into 3 groups: progress in disability ( At first MR imaging, there were no differences among progress in disability, disability improvement, and the stable groups in whole-brain volume ( Patients with MS who improve in their clinical disability develop less brain atrophy across time compared with those who progress.

Sections du résumé

BACKGROUND AND PURPOSE
It is unknown whether deceleration of brain atrophy is associated with disability improvement in patients with MS. Our aim was to investigate whether patients with MS with disability improvement develop less brain atrophy compared with those who progress in disability or remain stable.
MATERIALS AND METHODS
We followed 980 patients with MS for a mean of 4.8 ± 2.4 years. Subjects were divided into 3 groups: progress in disability (
RESULTS
At first MR imaging, there were no differences among progress in disability, disability improvement, and the stable groups in whole-brain volume (
CONCLUSIONS
Patients with MS who improve in their clinical disability develop less brain atrophy across time compared with those who progress.

Identifiants

DOI: 10.3174/ajnr.A6684 PMID: 32763899 PMC: PMC7583124
pubmed: 32763899
pii: ajnr.A6684
doi: 10.3174/ajnr.A6684
pmc: PMC7583124
doi:

Substances chimiques

Immunologic Factors 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

1577-1583

Subventions

Organisme : NCATS NIH HHS
ID : UL1 TR001412
Pays : United States

Informations de copyright

© 2020 by American Journal of Neuroradiology.

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Auteurs

E Ghione (E)

From the Department of Neurology (E.G., N.B., M.G.D., J.H., D.J., D.P.R., R.Z.), Buffalo Neuroimaging Analysis Center.
ORCID: 0000-0002-9516-2197

N Bergsland (N)

From the Department of Neurology (E.G., N.B., M.G.D., J.H., D.J., D.P.R., R.Z.), Buffalo Neuroimaging Analysis Center.
IRCCS (N.B.), Fondazione Don Carlo Gnocchi ONLUS, Milan, Italy.
ORCID: 0000-0002-7792-0433

M G Dwyer (MG)

From the Department of Neurology (E.G., N.B., M.G.D., J.H., D.J., D.P.R., R.Z.), Buffalo Neuroimaging Analysis Center.
Center for Biomedical Imaging at the Clinical Translational Science Institute (M.G.D., R.Z.),University at Buffalo, State University of New York, Buffalo, New York.
ORCID: 0000-0003-4684-4658

J Hagemeier (J)

From the Department of Neurology (E.G., N.B., M.G.D., J.H., D.J., D.P.R., R.Z.), Buffalo Neuroimaging Analysis Center.
ORCID: 0000-0002-3286-5207

D Jakimovski (D)

From the Department of Neurology (E.G., N.B., M.G.D., J.H., D.J., D.P.R., R.Z.), Buffalo Neuroimaging Analysis Center.
ORCID: 0000-0001-7114-4958

D P Ramasamy (DP)

From the Department of Neurology (E.G., N.B., M.G.D., J.H., D.J., D.P.R., R.Z.), Buffalo Neuroimaging Analysis Center.
ORCID: 0000-0003-0691-5087

D Hojnacki (D)

Department of Neurology (D.H., A.A.L., C.K., S.E., B.W.-G.), Jacobs Comprehensive MS Treatment and Research Center, Jacobs School of Medicine and Biomedical Sciences.
ORCID: 0000-0002-2518-848X

A A Lizarraga (AA)

Department of Neurology (D.H., A.A.L., C.K., S.E., B.W.-G.), Jacobs Comprehensive MS Treatment and Research Center, Jacobs School of Medicine and Biomedical Sciences.
ORCID: 0000-0003-1418-9775

C Kolb (C)

Department of Neurology (D.H., A.A.L., C.K., S.E., B.W.-G.), Jacobs Comprehensive MS Treatment and Research Center, Jacobs School of Medicine and Biomedical Sciences.
ORCID: 0000-0001-7761-2548

S Eckert (S)

Department of Neurology (D.H., A.A.L., C.K., S.E., B.W.-G.), Jacobs Comprehensive MS Treatment and Research Center, Jacobs School of Medicine and Biomedical Sciences.
ORCID: 0000-0003-3707-4014

B Weinstock-Guttman (B)

Department of Neurology (D.H., A.A.L., C.K., S.E., B.W.-G.), Jacobs Comprehensive MS Treatment and Research Center, Jacobs School of Medicine and Biomedical Sciences.
ORCID: 0000-0001-6732-151X

R Zivadinov (R)

From the Department of Neurology (E.G., N.B., M.G.D., J.H., D.J., D.P.R., R.Z.), Buffalo Neuroimaging Analysis Center rzivadinov@bnac.net.
Center for Biomedical Imaging at the Clinical Translational Science Institute (M.G.D., R.Z.),University at Buffalo, State University of New York, Buffalo, New York.
ORCID: 0000-0002-7799-1485

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Disability Improvement Is Associated with Less...
questionsmedicales.fr › États, signes et symptômes pathologiques › États anatomopathologiques › Atrophie › Disability Improvement Is Associated with Less...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Disability Improvement Is Associated with Less...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Évolution de la maladie › Disability Improvement Is Associated with Less...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Disability Improvement Is Associated with Less...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Facteurs immunologiques › Disability Improvement Is Associated with Less...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Disability Improvement Is Associated with Less...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Disability Improvement Is Associated with Less...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Maladies auto-immunes du système nerveux › Maladies démyélinisantes auto-immunes du SNC › Sclérose en plaques › Disability Improvement Is Associated with Less...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › Disability Improvement Is Associated with Less...