Insight into the dual function of lipid phosphate phosphatase PgpB involved in two essential cell-envelope metabolic pathways in Escherichia coli.
Amino Acid Motifs
Cell Membrane
/ metabolism
Escherichia coli
/ enzymology
Escherichia coli Proteins
/ genetics
Gene Knockout Techniques
Genetic Complementation Test
Hydrolysis
Membrane Proteins
/ metabolism
Metabolic Networks and Pathways
Models, Molecular
Penicillin-Binding Proteins
/ metabolism
Peptidoglycan Glycosyltransferase
/ metabolism
Phosphatidate Phosphatase
/ genetics
Phosphatidylglycerols
/ metabolism
Polyisoprenyl Phosphates
/ metabolism
Substrate Specificity
Thermotolerance
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
06 08 2020
06 08 2020
Historique:
received:
24
02
2020
accepted:
16
07
2020
entrez:
9
8
2020
pubmed:
9
8
2020
medline:
18
12
2020
Statut:
epublish
Résumé
Ubiquitous PAP2 lipid phosphatases are involved in a wide array of central physiological functions. PgpB from Escherichia coli constitutes the archetype of this subfamily of membrane proteins. It displays a dual function by catalyzing the biosynthesis of two essential lipids, the phosphatidylglycerol (PG) and the undecaprenyl phosphate (C
Identifiants
pubmed: 32764655
doi: 10.1038/s41598-020-70047-5
pii: 10.1038/s41598-020-70047-5
pmc: PMC7413402
doi:
Substances chimiques
Escherichia coli Proteins
0
Membrane Proteins
0
Penicillin-Binding Proteins
0
PgpB protein, E coli
0
Phosphatidylglycerols
0
Polyisoprenyl Phosphates
0
undecaprenyl phosphate
25126-51-6
Peptidoglycan Glycosyltransferase
EC 2.4.1.129
penicillin-binding protein 1A, E coli
EC 2.4.1.129
Phosphatidate Phosphatase
EC 3.1.3.4
pap2 protein, E coli
EC 3.1.3.4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
13209Références
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