Evaluation of Exertional Ventilatory Parameters Using Oscillometry in COPD.
airflow obstruction
dynamic hyperinflation
dyspnea
resonant frequency
tidal volume
Journal
International journal of chronic obstructive pulmonary disease
ISSN: 1178-2005
Titre abrégé: Int J Chron Obstruct Pulmon Dis
Pays: New Zealand
ID NLM: 101273481
Informations de publication
Date de publication:
2020
2020
Historique:
received:
30
04
2020
accepted:
02
07
2020
entrez:
9
8
2020
pubmed:
9
8
2020
medline:
29
6
2021
Statut:
epublish
Résumé
Oscillometry is a tool to measure respiratory impedance that requires minimal patients' effort. In patients with chronic obstructive pulmonary disease (COPD), the correlation of respiratory impedance at rest with exertional ventilatory parameters, including exercise tolerance, has scarcely been reported. In addition, the utility of oscillometric parameters might differ between the inspiratory and expiratory phases due to airflow obstruction during expiration, but the hypothesis had not been validated. The aim of the present study was to investigate whether oscillometric parameters are associated with exertional ventilatory parameters in patients with COPD. Fifty-five subjects with COPD who attended clinics at the National Hospital Organization Osaka Toneyama Medical Center performed spirometry, oscillometry, and cardiopulmonary exercise testing (CPET) within 2 weeks. The correlations between parameters of spirometry, oscillometry, and CPET were analyzed using Spearman's rank correlation coefficient, univariate, and multivariate analyses. Respiratory reactance had better correlations with the CPET parameters than respiratory resistance. Moreover, inspiratory reactance at rest correlated with the CPET parameters stronger than expiratory reactance. In particular, inspiratory resonant frequency (Fres-ins) correlated with peak oxygen uptake (r Measurement of respiratory reactance is useful for the effortless evaluation of not only exertional ventilatory parameters but exercise tolerance in patients with COPD. The correlation of respiratory impedance with exertional ventilatory parameters can become weak in patients with advanced COPD; thus, the measurement of oscillometry might not be appropriate for evaluating exertional ventilatory parameters of patients with advanced COPD.
Sections du résumé
Background
Oscillometry is a tool to measure respiratory impedance that requires minimal patients' effort. In patients with chronic obstructive pulmonary disease (COPD), the correlation of respiratory impedance at rest with exertional ventilatory parameters, including exercise tolerance, has scarcely been reported. In addition, the utility of oscillometric parameters might differ between the inspiratory and expiratory phases due to airflow obstruction during expiration, but the hypothesis had not been validated. The aim of the present study was to investigate whether oscillometric parameters are associated with exertional ventilatory parameters in patients with COPD.
Methods
Fifty-five subjects with COPD who attended clinics at the National Hospital Organization Osaka Toneyama Medical Center performed spirometry, oscillometry, and cardiopulmonary exercise testing (CPET) within 2 weeks. The correlations between parameters of spirometry, oscillometry, and CPET were analyzed using Spearman's rank correlation coefficient, univariate, and multivariate analyses.
Results
Respiratory reactance had better correlations with the CPET parameters than respiratory resistance. Moreover, inspiratory reactance at rest correlated with the CPET parameters stronger than expiratory reactance. In particular, inspiratory resonant frequency (Fres-ins) correlated with peak oxygen uptake (r
Conclusion
Measurement of respiratory reactance is useful for the effortless evaluation of not only exertional ventilatory parameters but exercise tolerance in patients with COPD. The correlation of respiratory impedance with exertional ventilatory parameters can become weak in patients with advanced COPD; thus, the measurement of oscillometry might not be appropriate for evaluating exertional ventilatory parameters of patients with advanced COPD.
Identifiants
pubmed: 32764915
doi: 10.2147/COPD.S260735
pii: 260735
pmc: PMC7367741
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1697-1711Informations de copyright
© 2020 Yamamoto et al.
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest in association with the present study.
Références
Lancet. 2018 Nov 10;392(10159):1736-1788
pubmed: 30496103
Int J Chron Obstruct Pulmon Dis. 2014 Feb 15;9:187-201
pubmed: 24600216
Ann Am Thorac Soc. 2017 Jul;14(Supplement_1):S22-S29
pubmed: 28345959
Chest. 2014 Sep;146(3):841-847
pubmed: 25180727
Bone Marrow Transplant. 2013 Mar;48(3):452-8
pubmed: 23208313
Respir Investig. 2014 Jul;52(4):242-50
pubmed: 24998371
Eur Respir J. 2000 Aug;16(2):269-75
pubmed: 10968502
Respir Med. 2006 Dec;100(12):2207-19
pubmed: 16713226
Eur Respir J. 2007 Feb;29(2):363-74
pubmed: 17079262
Int J Chron Obstruct Pulmon Dis. 2016 May 26;11:1105-18
pubmed: 27307726
Eur Respir J. 2003 Dec;22(6):1026-41
pubmed: 14680096
N Engl J Med. 2011 Oct 27;365(17):1567-75
pubmed: 22029978
Int J Chron Obstruct Pulmon Dis. 2012;7:259-69
pubmed: 22589578
Am J Respir Crit Care Med. 2002 Jul 1;166(1):111-7
pubmed: 12091180
Eur Respir Rev. 2016 Sep;25(141):333-47
pubmed: 27581832
Proc Am Thorac Soc. 2006 Apr;3(2):180-4
pubmed: 16565429
Respir Care. 2012 Apr;57(4):583-9
pubmed: 22005099
Eur Respir J. 2017 Mar 8;49(3):
pubmed: 28275174
Int J Chron Obstruct Pulmon Dis. 2017 Oct 03;12:2859-2868
pubmed: 29042766
Eur Respir J. 2005 Aug;26(2):319-38
pubmed: 16055882
Eur Respir J. 2005 Jan;25(1):186-99
pubmed: 15640341
Am J Respir Crit Care Med. 2015 Jun 15;191(12):1384-94
pubmed: 25826478
Respir Physiol Neurobiol. 2009 Apr 30;166(2):73-9
pubmed: 19429522
Chest. 2011 Aug;140(2):331-342
pubmed: 21273294
Am J Respir Crit Care Med. 2003 Jan 15;167(2):211-77
pubmed: 12524257
J Appl Physiol (1985). 1997 Mar;82(3):723-31
pubmed: 9074955
Eur Respir J. 2004 Feb;23(2):232-40
pubmed: 14979497
Thorax. 2010 Mar;65(3):263-7
pubmed: 20335298
Br J Clin Pharmacol. 2008 Feb;65(2):244-52
pubmed: 18251761
Intern Med. 2016;55(6):559-66
pubmed: 26984069
Respir Med. 2017 Jun;127:7-13
pubmed: 28502420
Eur Respir J. 2016 Feb;47(2):429-60
pubmed: 26797036
Pediatr Pulmonol. 2002 Oct;34(4):312-9
pubmed: 12205573
Int J Chron Obstruct Pulmon Dis. 2020 Jan 21;15:157-166
pubmed: 32021155
Respir Physiol Neurobiol. 2016 Jan;220:62-8
pubmed: 26369446
Eur Respir J. 2018 Feb 7;51(2):
pubmed: 29437936