Geroscience in the Age of COVID-19.
COVID-19
aging biomarkers
geroprotectors
geroscience
immunosenescence
Journal
Aging and disease
ISSN: 2152-5250
Titre abrégé: Aging Dis
Pays: United States
ID NLM: 101540533
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
received:
20
06
2020
accepted:
29
06
2020
entrez:
9
8
2020
pubmed:
9
8
2020
medline:
9
8
2020
Statut:
epublish
Résumé
The data on COVID-19 is clear on at least one point: Older adults are most vulnerable to hospitalization, disability and death following infection with the novel coronavirus. Therefore, therapeutically addressing degenerative aging processes as the main risk factors appears promising for tackling the present crisis and is expected to be relevant when tackling future infections, epidemics and pandemics. Therefore, utilizing a geroscience approach, targeting aging processes to prevent multimorbidity, via initiating broad clinical trials of potential geroprotective therapies, is recommended.
Identifiants
pubmed: 32765937
doi: 10.14336/AD.2020.0629
pii: ad-11-4-725
pmc: PMC7390533
doi:
Types de publication
Editorial
Langues
eng
Pagination
725-729Subventions
Organisme : NIA NIH HHS
ID : R37 AG021904
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG054108
Pays : United States
Informations de copyright
Copyright: © 2020 Barzilai et al.
Références
Proc Natl Acad Sci U S A. 2015 Jul 28;112(30):E4104-10
pubmed: 26150497
Cell Metab. 2020 Jul 7;32(1):15-30
pubmed: 32333835
Aging Dis. 2014 Dec 15;6(1):1-5
pubmed: 25657847
Am J Trop Med Hyg. 2020 Jul;103(1):69-72
pubmed: 32446312
Exp Gerontol. 2018 May;105:53-69
pubmed: 29408453
Aging Cell. 2015 Aug;14(4):497-510
pubmed: 25902704
Milbank Q. 2002;80(1):155-74
pubmed: 11933792
JAMA. 2020 Apr 22;:
pubmed: 32320003
Diabetologia. 2017 Sep;60(9):1566-1576
pubmed: 28776081
Science. 2015 Dec 4;350(6265):1191-3
pubmed: 26785476
Cell. 2013 Jun 6;153(6):1194-217
pubmed: 23746838
Sci Signal. 2009 Nov 24;2(98):ra75
pubmed: 19934433
Aging Cell. 2020 Feb;19(2):e13080
pubmed: 31833194
Aging Dis. 2018 Apr 1;9(2):331-333
pubmed: 29896422
Cell. 2014 Nov 6;159(4):709-13
pubmed: 25417146
Aging Dis. 2017 Oct 1;8(5):583-589
pubmed: 28966803
Aging (Albany NY). 2019 Oct 4;11(19):8048-8067
pubmed: 31586989
JAMA. 2020 Feb 24;:
pubmed: 32091533
Sci Transl Med. 2018 Jul 11;10(449):
pubmed: 29997249
Vaccine. 2017 May 9;35(20):2694-2700
pubmed: 28392139
Geroscience. 2017 Feb;39(1):1-5
pubmed: 28299635
J Gerontol A Biol Sci Med Sci. 2016 Nov;71(11):1424-1434
pubmed: 27535968
Int J Infect Dis. 2020 May;94:91-95
pubmed: 32173574
Sci Transl Med. 2014 Dec 24;6(268):268ra179
pubmed: 25540326
Cell Metab. 2016 Jun 14;23(6):1060-1065
pubmed: 27304507
N Engl J Med. 2020 Apr 23;382(17):1653-1659
pubmed: 32227760
Immunology. 2007 Apr;120(4):435-46
pubmed: 17313487