Metabolomic signature of the seminal plasma in men with severe oligoasthenospermia.
Adult
Amines
/ analysis
Amino Acids
/ analysis
Carnitine
/ analogs & derivatives
Fatty Acids, Unsaturated
/ analysis
Humans
Male
Metabolome
/ physiology
Metabolomics
/ methods
Oligospermia
/ metabolism
Phosphatidylcholines
/ analysis
Prospective Studies
Semen
/ cytology
Semen Analysis
Sperm Motility
/ physiology
Spermatozoa
/ pathology
Sphingomyelins
/ analysis
lipidomics
male infertility
metabolomics
oligoasthenospermia
seminal plasma
Journal
Andrology
ISSN: 2047-2927
Titre abrégé: Andrology
Pays: England
ID NLM: 101585129
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
02
06
2020
revised:
21
07
2020
accepted:
30
07
2020
pubmed:
10
8
2020
medline:
7
10
2021
entrez:
10
8
2020
Statut:
ppublish
Résumé
Male factor is incriminated in approximately 50% of cases of infertility. The metabolomic approach has recently been used in the assessment of sperm quality and male fertility. We analyzed the metabolomic signatures of the seminal plasma in 20 men with severe oligoasthenospermia (prewash total motile sperm count < 5.10 Among the 188 metabolites analyzed, 110 were accurately measured in the seminal plasma. A robust model discriminating the two populations (Q Our signature includes several metabolic changes with different impacts on the sperm quality: a change in phospholipid composition and the saturation of their fatty acids that is potentially linked to the deterioration of sperm membranes; a carnitine deficiency that can negatively impact the energy production via fatty acid oxidation and oxidative phosphorylation; and a decreased level of amino acids and biogenic amines that can lead to dysregulated metabolic and signaling pathways. We provide a global overview of the metabolic defects contributing to the structural and functional alteration of spermatozoa in severe oligoasthenospermia. These findings offer new insights into the pathophysiology of male factor infertility that could help to develop future specific treatments.
Sections du résumé
BACKGROUND
Male factor is incriminated in approximately 50% of cases of infertility. The metabolomic approach has recently been used in the assessment of sperm quality and male fertility.
MATERIALS AND METHODS
We analyzed the metabolomic signatures of the seminal plasma in 20 men with severe oligoasthenospermia (prewash total motile sperm count < 5.10
RESULTS
Among the 188 metabolites analyzed, 110 were accurately measured in the seminal plasma. A robust model discriminating the two populations (Q
DISCUSSION
Our signature includes several metabolic changes with different impacts on the sperm quality: a change in phospholipid composition and the saturation of their fatty acids that is potentially linked to the deterioration of sperm membranes; a carnitine deficiency that can negatively impact the energy production via fatty acid oxidation and oxidative phosphorylation; and a decreased level of amino acids and biogenic amines that can lead to dysregulated metabolic and signaling pathways.
CONCLUSION
We provide a global overview of the metabolic defects contributing to the structural and functional alteration of spermatozoa in severe oligoasthenospermia. These findings offer new insights into the pathophysiology of male factor infertility that could help to develop future specific treatments.
Substances chimiques
Amines
0
Amino Acids
0
Fatty Acids, Unsaturated
0
Phosphatidylcholines
0
Sphingomyelins
0
acylcarnitine
0
Carnitine
S7UI8SM58A
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
1859-1866Informations de copyright
© 2020 American Society of Andrology and European Academy of Andrology.
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