Expression of discoidin domain receptor 1 and E-cadherin in epidermis affects melanocyte behavior in rhododendrol-induced leukoderma mouse model.
E-cadherin
discoidin domain receptor 1
melanocytorrhagy
rhododendrol-induced leukoderma
vitiligo
Journal
The Journal of dermatology
ISSN: 1346-8138
Titre abrégé: J Dermatol
Pays: England
ID NLM: 7600545
Informations de publication
Date de publication:
Nov 2020
Nov 2020
Historique:
received:
25
02
2020
accepted:
04
07
2020
pubmed:
10
8
2020
medline:
15
5
2021
entrez:
10
8
2020
Statut:
ppublish
Résumé
Vitiligo is a depigmentation disease characterized by gradual loss of melanin and melanocytes from the epidermis. The mechanism of melanocyte loss is not yet known. In this report, we showed that the expression of discoidin domain receptor 1 and E-cadherin, known adhesion molecules, was variable or absent in the epidermis of rhododendrol-induced leukoderma (RDIL) mice during the depigmentation process. Our findings suggest that melanocyte damage by rhododendrol promotes reduction of adhesion molecules not only in melanocytes but also in keratinocytes, and this is associated with the detachment of melanocytes from the basal layer.
Identifiants
pubmed: 32770866
doi: 10.1111/1346-8138.15534
doi:
Substances chimiques
Butanols
0
Cadherins
0
rhododendrol
12QWN45UL0
Discoidin Domain Receptor 1
EC 2.7.10.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1330-1334Subventions
Organisme : Japan Society for the Promotion of Science KAKENHI
ID : 19K08742
Informations de copyright
© 2020 Japanese Dermatological Association.
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