Identifying Cardiac Amyloid in Aortic Stenosis: ECV Quantification by CT in TAVR Patients.
aortic stenosis
cardiac amyloidosis
computed tomography
extracellular volume
Journal
JACC. Cardiovascular imaging
ISSN: 1876-7591
Titre abrégé: JACC Cardiovasc Imaging
Pays: United States
ID NLM: 101467978
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
24
03
2020
revised:
18
05
2020
accepted:
20
05
2020
pubmed:
11
8
2020
medline:
12
8
2021
entrez:
11
8
2020
Statut:
ppublish
Résumé
The purpose of this study was to validate computed tomography measured ECV (ECV AS-amyloid affects 1 in 7 elderly patients referred for transcatheter aortic valve replacement (TAVR). Bone scintigraphy with exclusion of a plasma cell dyscrasia can diagnose transthyretin-related cardiac amyloid noninvasively, for which novel treatments are emerging. Amyloid interstitial expansion increases the myocardial extracellular volume (ECV). Patients with severe AS underwent bone scintigraphy (Perugini grade 0, negative; Perugini grades 1 to 3, increasingly positive) and routine TAVR evaluation CT imaging with ECV A total of 109 patients (43% male; mean age 86 ± 5 years) with severe AS and 20 control subjects were recruited. Sixteen (15%) had AS-amyloid on bone scintigraphy (grade 1, n = 5; grade 2, n = 11). ECV ECV
Sections du résumé
OBJECTIVES
The purpose of this study was to validate computed tomography measured ECV (ECV
BACKGROUND
AS-amyloid affects 1 in 7 elderly patients referred for transcatheter aortic valve replacement (TAVR). Bone scintigraphy with exclusion of a plasma cell dyscrasia can diagnose transthyretin-related cardiac amyloid noninvasively, for which novel treatments are emerging. Amyloid interstitial expansion increases the myocardial extracellular volume (ECV).
METHODS
Patients with severe AS underwent bone scintigraphy (Perugini grade 0, negative; Perugini grades 1 to 3, increasingly positive) and routine TAVR evaluation CT imaging with ECV
RESULTS
A total of 109 patients (43% male; mean age 86 ± 5 years) with severe AS and 20 control subjects were recruited. Sixteen (15%) had AS-amyloid on bone scintigraphy (grade 1, n = 5; grade 2, n = 11). ECV
CONCLUSIONS
ECV
Identifiants
pubmed: 32771574
pii: S1936-878X(20)30509-X
doi: 10.1016/j.jcmg.2020.05.029
pmc: PMC7536272
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2177-2189Subventions
Organisme : British Heart Foundation
ID : FS/19/35/34374
Pays : United Kingdom
Organisme : British Heart Foundation
ID : FS/16/31/32185
Pays : United Kingdom
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.
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