Anti-obesity effect of a hop-derived prenylflavonoid isoxanthohumol in a high-fat diet-induced obese mouse model.
Akkermansia
hop
isoxanthohumol
microbiome
obesity
Journal
Bioscience of microbiota, food and health
ISSN: 2186-6953
Titre abrégé: Biosci Microbiota Food Health
Pays: Japan
ID NLM: 101578264
Informations de publication
Date de publication:
2020
2020
Historique:
received:
02
11
2019
accepted:
10
03
2020
entrez:
11
8
2020
pubmed:
11
8
2020
medline:
11
8
2020
Statut:
ppublish
Résumé
We examined whether oral administration of a hop-derived prenylflavonoid isoxanthohumol (IX) would show anti-obesity activity and the underlying mechanism of the potential activity using a high-fat diet (HFD)-induced obese mouse model. Oral administration of 180 mg/kg IX for 8 weeks suppressed HFD-induced accumulation of visceral fat and body weight gain in mice. Simultaneously, IX changed the composition of the microbiome, as determined by a significant increase in the relative abundances of
Identifiants
pubmed: 32775137
doi: 10.12938/bmfh.2019-040
pii: 2019-040
pmc: PMC7392919
doi:
Types de publication
Journal Article
Langues
eng
Pagination
175-182Informations de copyright
©2020 BMFH Press.
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