Association of blood pressure changes with survival after paramedic rapid sequence intubation in out-of-hospital patients with stroke.


Journal

Emergency medicine Australasia : EMA
ISSN: 1742-6723
Titre abrégé: Emerg Med Australas
Pays: Australia
ID NLM: 101199824

Informations de publication

Date de publication:
02 2021
Historique:
received: 27 02 2020
revised: 03 07 2020
accepted: 05 07 2020
pubmed: 11 8 2020
medline: 19 8 2021
entrez: 11 8 2020
Statut: ppublish

Résumé

Rapid sequence intubation (RSI) is used to secure the airway of some patients with stroke. Recent observational studies suggest that RSI is associated with poorer survival, and that decreases in systolic blood pressure (BP) following RSI could be a cause of worse survival. The present study aims to find if decreased systolic BP after paramedic RSI is associated with poorer survival in stroke patients transported by ambulance. The present study was a retrospective analysis of all stroke patients who received paramedic RSI attended by Ambulance Victoria, Australia. Logistic regression predicted the survival for strokes that had received RSI. The change in systolic BP during paramedic care was the main predictor. Of 43 831 patients with stroke, 882 (2%) received RSI. Almost 48% of RSI had a decline in systolic BP of more than 20% from baseline, and the decline in systolic BP after RSI was largest for intra-cerebral haemorrhage (-22.7 mmHg) compared to ischaemic strokes (-10.1 mmHg) or subarachnoid haemorrhage (-15.6 mmHg) (P = 0.001). Sixteen percent of the RSI group had an episode of hypotension anytime during the out-of-hospital care. For each 10 mmHg decrease in systolic BP with RSI for intra-cerebral haemorrhage an increase of 11% in the odds of survival is apparent (P = 0.04); for subarachnoid haemorrhage an increase of 17% (P = 0.02) and for ischaemic strokes a non-significant decrease of 7% (P = 0.26). Paramedic RSI-related decrease in systolic BP is associated with improved survival in those with intra-cerebral or subarachnoid haemorrhage but not ischaemic stroke.

Identifiants

pubmed: 32776485
doi: 10.1111/1742-6723.13594
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

94-99

Informations de copyright

© 2020 Australasian College for Emergency Medicine.

Références

GBD Causes of Death Collaborators. Global, regional, and national age-sex specific mortality for 264 causes of death, 1980-2016: a systematic analysis for the global burden of disease study 2016. Lancet 2017; 390: 1151-210.
Fouche PF, Stein C, Jennings PA, Boyle M, Bernard S, Smith K. Review article: emergency endotracheal intubation in non-traumatic brain pathologies: a systematic review and meta-analysis. Emerg. Med. Australas. 2019; 31: 533-41.
Fouche PF, Jennings PA, Smith K et al. Survival in out-of-hospital rapid sequence intubation of non-traumatic brain pathologies. Prehosp. Emerg. Care 2017; 21: 700-8.
Fouche PF, Smith K, Jennings PA, Boyle M, Bernard S. The association of paramedic rapid sequence intubation and survival in out-of-hospital stroke. Emerg. Med. J. 2019; 36: 416-22.
Fouche PF, Jennings PA, Boyle M, Bernard S, Smith K. The utility of the brain trauma evidence to inform paramedic rapid sequence intubation in out-of-hospital stroke. BMC Emerg. Med. 2020; 20: 5.
Ambulance Victoria. Clinical Practice Guidelines for Ambulance and MICA Paramedics. Version 1.1 ed. Doncaster: Ambulance Victoria, 2016.
Mansour O, Megahed M, Abd Elghany E. Acute ischemic stroke prognostication, comparison between Glasgow Coma Score, NIHS Scale and Full Outline of UnResponsiveness Score in intensive care unit. Alexandria Med. J. 2015; 51: 247-53.
van Walraven C, Austin PC, Jennings A, Quan H, Forster AJ. A modification of the Elixhauser comorbidity measures into a point system for hospital death using administrative data. Med. Care 2009; 47: 626-33.
Montgomery JM, Nyhan B, Torres M. How conditioning on posttreatment variables can ruin your experiment and what to do about it. Am. J. Polit. Sci. 2018; 62: 760-75.
Perkins ZB, Gunning M, Crilly J, Lockey D, O'Brien B. The haemodynamic response to pre-hospital RSI in injured patients. Injury 2013; 44: 618-23.
Hosmer DW, Lemeshow S, Sturdivant RX. Applied Logistic Regression. Wiley Series in Probability and Statistics, 3rd edn. Hoboken, NJ: Wiley, 2013.
Perkins ZB, Wittenberg MD, Nevin D, Lockey DJ, O'Brien B. The relationship between head injury severity and hemodynamic response to tracheal intubation. J. Trauma Acute Care Surg. 2013; 74: 1074-80.
Fischer U, Mattle HP. Blood pressure in acute stroke: still no answer for management. Stroke 2017; 48: 1717-9.
Britton M, Carlsson A, de Faire U. Blood pressure course in patients with acute stroke and matched controls. Stroke 1986; 17: 861-4.
Lattanzi S, Silvestrini M. Blood pressure in acute intra-cerebral hemorrhage. Ann. Transl. Med. 2016; 4: 320.
Bath PM, Scutt P, Anderson CS et al. Prehospital transdermal glyceryl trinitrate in patients with ultra-acute presumed stroke (RIGHT-2): an ambulance-based, randomised, sham-controlled, blinded, phase 3 trial. Lancet 2019; 393: 1009-20.
Anderson CS, Heeley E, Huang Y et al. Rapid blood-pressure lowering in patients with acute intracerebral hemorrhage. N. Engl. J. Med. 2013; 368: 2355-65.
Sherman RE, Anderson SA, Dal Pan GJ et al. Real-world evidence - what is it and what can it tell us? N. Engl. J. Med. 2016; 375: 2293-7.
Sjoding MW, Luo K, Miller MA, Iwashyna TJ. When do confounding by indication and inadequate risk adjustment bias critical care studies? A simulation study. Crit. Care 2015; 19: 195.

Auteurs

Pieter F Fouche (PF)

Department of Paramedicine, Monash University, Melbourne, Victoria, Australia.

Paul A Jennings (PA)

Department of Paramedicine, Monash University, Melbourne, Victoria, Australia.
Ambulance Victoria, Barwon, Victoria, Australia.

Malcolm Boyle (M)

School of Medicine, Griffith University, Gold Coast, Queensland, Australia.

Stephen Bernard (S)

Research and Evaluation, Ambulance Victoria, Melbourne, Victoria, Australia.

Karen Smith (K)

Department of Paramedicine, Monash University, Melbourne, Victoria, Australia.
Research and Evaluation, Ambulance Victoria, Melbourne, Victoria, Australia.
Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.

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